{"id":"https://openalex.org/W1968248461","doi":"https://doi.org/10.1073/pnas.1100314108","title":"Epigenetic control of vasopressin expression is maintained by steroid hormones in the adult male rat brain","display_name":"Epigenetic control of vasopressin expression is maintained by steroid hormones in the adult male rat brain","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W1968248461","doi":"https://doi.org/10.1073/pnas.1100314108","mag":"1968248461","pmid":"https://pubmed.ncbi.nlm.nih.gov/21368111","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3053981"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1100314108","doi":"https://doi.org/10.1073/pnas.1100314108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1100314108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3053981/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091721055","display_name":"Catherine J. Auger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine J. Auger","raw_affiliation_strings":["Department of Psychology and","Neuroscience Training Program, University of Wisconsin, Madison, WI 53706","Department of Psychology and; Neuroscience Training Program, University of Wisconsin, Madison, WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Training Program, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Psychology and; Neuroscience Training Program, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047050876","display_name":"Dylan Coss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dylan Coss","raw_affiliation_strings":["Department of Psychology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159107","display_name":"Anthony P. Auger","orcid":"https://orcid.org/0009-0002-9641-0348","observed_orcids":["https://orcid.org/0009-0002-9641-0348"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony P. Auger","raw_affiliation_strings":["Department of Psychology and","Neuroscience Training Program, University of Wisconsin, Madison, WI 53706","Department of Psychology and; Neuroscience Training Program, University of Wisconsin, Madison, WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Training Program, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Psychology and; Neuroscience Training Program, University of Wisconsin, Madison, WI 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009815719","display_name":"Robin M. Forbes\u2010Lorman","orcid":"https://orcid.org/0000-0003-3935-6541","observed_orcids":["https://orcid.org/0000-0003-3935-6541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin M. Forbes-Lorman","raw_affiliation_strings":["Department of Psychology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3166,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.9599007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"108","issue":"10","first_page":"4242","last_page":"4247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.7820000052452087},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8999999761581421},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.9409999847412109},{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bed-nucleus-of-the-stria-terminalis","display_name":"bed nucleus of the stria terminalis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cpg-sites","display_name":"CpG sites","score":0.8090000152587891},{"id":"https://openalex.org/keywords/adult-brain","display_name":"adult brain","score":0.6570000052452087},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7264041900634766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7213413715362549},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7049535512924194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6452013254165649},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6165485382080078},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5979979038238525},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5505821108818054},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.519280195236206},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5157347321510315},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5124226212501526},{"id":"https://openalex.org/C15660099","wikidata":"https://www.wikidata.org/wiki/Q7458508","display_name":"Sex hormone receptor","level":5,"score":0.4538021683692932},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.43486344814300537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2316247522830963},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.21058392524719238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08432221412658691},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06911611557006836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06434613466262817},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1100314108","doi":"https://doi.org/10.1073/pnas.1100314108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1100314108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:21368111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21368111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3053981","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3053981/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3053981","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3053981/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2003085819","display_name":"Steroid Receptors and Brain Sex Differences","funder_award_id":"R01MH072956","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1826577257","https://openalex.org/W1969720359","https://openalex.org/W1970725106","https://openalex.org/W1975467089","https://openalex.org/W1978604386","https://openalex.org/W1980877862","https://openalex.org/W1984203742","https://openalex.org/W2009365074","https://openalex.org/W2010659314","https://openalex.org/W2010711792","https://openalex.org/W2011650965","https://openalex.org/W2014166259","https://openalex.org/W2016704563","https://openalex.org/W2020767030","https://openalex.org/W2027848195","https://openalex.org/W2031577596","https://openalex.org/W2038208040","https://openalex.org/W2039699813","https://openalex.org/W2040205249","https://openalex.org/W2047344313","https://openalex.org/W2052593207","https://openalex.org/W2060889804","https://openalex.org/W2064899241","https://openalex.org/W2066126226","https://openalex.org/W2069085535","https://openalex.org/W2070780249","https://openalex.org/W2077249217","https://openalex.org/W2078028724","https://openalex.org/W2078908871","https://openalex.org/W2080204119","https://openalex.org/W2089284490","https://openalex.org/W2091602444","https://openalex.org/W2101036608","https://openalex.org/W2104594573","https://openalex.org/W2107277218","https://openalex.org/W2129738259","https://openalex.org/W2133925293","https://openalex.org/W2140892602","https://openalex.org/W2163815564","https://openalex.org/W2169196164","https://openalex.org/W2170146128","https://openalex.org/W2170760271"],"related_works":["https://openalex.org/W2075771005","https://openalex.org/W2096313369","https://openalex.org/W7095860898","https://openalex.org/W2057022979","https://openalex.org/W2061840967","https://openalex.org/W2133925293","https://openalex.org/W2035757844","https://openalex.org/W1965097218","https://openalex.org/W2080204119","https://openalex.org/W2068838328"],"abstract_inverted_index":{"Although":[0],"some":[1,180,206],"DNA":[2,26,93,175],"methylation":[3,27,134,160,177],"patterns":[4,28],"are":[5,88],"altered":[6],"by":[7,168,191,212],"steroid":[8,22,181,196,216],"hormone":[9,23],"exposure":[10],"in":[11,21,29,36,85,92,103,127,143,184,208,222],"the":[12,30,37,45,48,55,59,81,98,104,114,140,144,162,174,185,192,209,213,223],"developing":[13],"brain,":[14],"less":[15],"is":[16,66,107,188],"known":[17],"about":[18],"how":[19],"changes":[20,165],"levels":[24],"influence":[25],"adult":[31,38,64,105,123,186,210],"brain.":[32],"Steroid":[33],"hormones":[34,217],"act":[35],"brain":[39,65,106,187,211],"to":[40],"regulate":[41],"gene":[42,116],"expression.":[43],"Specifically,":[44],"expression":[46,79,87,102,131,155],"of":[47,58,63,113,122,135,179,194,200,205,215,226],"socially":[49],"relevant":[50,228],"peptide":[51],"vasopressin":[52],"(AVP)":[53],"within":[54,80,139,161],"bed":[56],"nucleus":[57],"stria":[60],"terminalis":[61],"(BST)":[62],"dependent":[67],"upon":[68],"testosterone":[69,75,169],"exposure.":[70],"Castration":[71],"dramatically":[72],"reduces":[73],"and":[74,132,156],"replacement":[76],"restores":[77],"AVP":[78,101,115,129,141],"BST.":[82,145,163],"As":[83],"decreases":[84],"mRNA":[86,130,154],"associated":[89],"with":[90],"increases":[91],"promoter":[94,142,159,176],"methylation,":[95],"we":[96],"explored":[97],"hypothesis":[99],"that":[100,120,173],"maintained":[108,190],"through":[109],"sustained":[110],"epigenetic":[111],"modifications":[112],"promoter.":[117],"We":[118],"find":[119],"castration":[121,147],"male":[124],"rats":[125],"resulted":[126],"decreased":[128,157],"increased":[133,149],"specific":[136],"CpG":[137],"sites":[138],"Similarly,":[146],"significantly":[148],"estrogen":[150],"receptor":[151],"\u03b1":[152],"(ER\u03b1)":[153],"ER\u03b1":[158],"These":[164],"were":[166],"prevented":[167],"replacement.":[170],"This":[171],"suggests":[172],"status":[178],"responsive":[182],"genes":[183,207],"actively":[189],"presence":[193,214],"circulating":[195],"hormones.":[197],"The":[198],"maintenance":[199],"methylated":[201],"or":[202],"demethylated":[203],"states":[204],"may":[218],"play":[219],"a":[220],"role":[221],"homeostatic":[224],"regulation":[225],"behaviorally":[227],"systems.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}