{"id":"https://openalex.org/W1968235575","doi":"https://doi.org/10.1016/j.carbpol.2012.02.051","title":"Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation","display_name":"Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation","publication_year":2012,"publication_date":"2012-02-28","ids":{"openalex":"https://openalex.org/W1968235575","doi":"https://doi.org/10.1016/j.carbpol.2012.02.051","mag":"1968235575","pmid":"https://pubmed.ncbi.nlm.nih.gov/24750606"},"language":"en","primary_location":{"id":"doi:10.1016/j.carbpol.2012.02.051","doi":"https://doi.org/10.1016/j.carbpol.2012.02.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.carbpol.2012.02.051","pdf_url":null,"source":{"id":"https://openalex.org/S64311837","display_name":"Carbohydrate Polymers","issn_l":"0144-8617","issn":["0144-8617","1879-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045432062","display_name":"Shadabul Haque","orcid":"https://orcid.org/0000-0002-3224-2149","observed_orcids":["https://orcid.org/0000-0002-3224-2149"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shadabul Haque","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India; Ranbaxy Research Laboratories, Gurgaon, India","Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","Ranbaxy Research Laboratories, Gurgaon, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India; Ranbaxy Research Laboratories, Gurgaon, India","institution_ids":["https://openalex.org/I19716509"]},{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","institution_ids":["https://openalex.org/I19716509"]},{"raw_affiliation_string":"Ranbaxy Research Laboratories, Gurgaon, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023348528","display_name":"Shadab Md","orcid":"https://orcid.org/0000-0002-9343-1066","observed_orcids":["https://orcid.org/0000-0002-9343-1066"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shadab Md","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110282783","display_name":"Mohammad Fazil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohammad Fazil","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080588119","display_name":"Manish Kumar","orcid":"https://orcid.org/0000-0003-2042-1243","observed_orcids":["https://orcid.org/0000-0003-2042-1243","https://orcid.org/0009-0006-6546-8888"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]},{"id":"https://openalex.org/I4405281529","display_name":"Advanced Instrumentation Research Facility","ror":"https://ror.org/04fzy3t83","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152429107","https://openalex.org/I4405281529"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Kumar","raw_affiliation_strings":["Advanced Instrumentation Research Facility, Jawaharlal Nehru University, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Instrumentation Research Facility, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107","https://openalex.org/I4405281529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113737300","display_name":"Jasjeet Kaur Sahni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jasjeet Kaur Sahni","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025737605","display_name":"Javed Ali","orcid":"https://orcid.org/0000-0001-5308-0655","observed_orcids":["https://orcid.org/0000-0001-5308-0655"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Javed Ali","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049947030","display_name":"Sanjula Baboota","orcid":"https://orcid.org/0000-0003-1508-6786","observed_orcids":["https://orcid.org/0000-0003-1508-6786"]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sanjula Baboota","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India","institution_ids":["https://openalex.org/I19716509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049947030"],"corresponding_institution_ids":["https://openalex.org/I19716509"],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":6.1284,"has_fulltext":false,"cited_by_count":161,"citation_normalized_percentile":{"value":0.97519213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"89","issue":"1","first_page":"72","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":1.0},{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9419999718666077},{"id":"https://openalex.org/keywords/brain-targeting","display_name":"brain targeting","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brain-to-blood-ratio","display_name":"brain-to-blood ratio","score":0.6759999990463257},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9789999723434448},{"id":"https://openalex.org/keywords/confocal-laser-scanning-microscopy","display_name":"confocal laser scanning microscopy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8259999752044678},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.828000009059906},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.73702472448349},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6933843493461609},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6350456476211548},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6026945114135742},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6011566519737244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45628461241722107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31265193223953247},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.13828563690185547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10451444983482361},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06579247117042542},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.carbpol.2012.02.051","doi":"https://doi.org/10.1016/j.carbpol.2012.02.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.carbpol.2012.02.051","pdf_url":null,"source":{"id":"https://openalex.org/S64311837","display_name":"Carbohydrate Polymers","issn_l":"0144-8617","issn":["0144-8617","1879-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate Polymers","raw_type":"journal-article"},{"id":"pmid:24750606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24750606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate polymers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W195513463","https://openalex.org/W206156325","https://openalex.org/W1485563738","https://openalex.org/W1498725963","https://openalex.org/W1499012581","https://openalex.org/W1867335213","https://openalex.org/W2002675502","https://openalex.org/W2005651839","https://openalex.org/W2019836676","https://openalex.org/W2022302125","https://openalex.org/W2023205673","https://openalex.org/W2025486324","https://openalex.org/W2027900665","https://openalex.org/W2038458795","https://openalex.org/W2041469738","https://openalex.org/W2041611624","https://openalex.org/W2051215695","https://openalex.org/W2055605461","https://openalex.org/W2061264254","https://openalex.org/W2071587107","https://openalex.org/W2077134890","https://openalex.org/W2077756131","https://openalex.org/W2091983858","https://openalex.org/W2093918270","https://openalex.org/W2100225360","https://openalex.org/W2106536537","https://openalex.org/W2110084899","https://openalex.org/W2113513792","https://openalex.org/W2114179943","https://openalex.org/W2131167630","https://openalex.org/W2154272253","https://openalex.org/W2156946852","https://openalex.org/W2197078876"],"related_works":["https://openalex.org/W2566436841","https://openalex.org/W4248221389","https://openalex.org/W4376144217","https://openalex.org/W2014202811","https://openalex.org/W7162649188","https://openalex.org/W2982726692","https://openalex.org/W1992535564","https://openalex.org/W2895875666","https://openalex.org/W1004290753","https://openalex.org/W4402229280"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}