{"id":"https://openalex.org/W1968227643","doi":"https://doi.org/10.1111/apha.12006","title":"Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine R y R 2\u2010 P 2328 S hearts","display_name":"Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine R y R 2\u2010 P 2328 S hearts","publication_year":2012,"publication_date":"2012-09-07","ids":{"openalex":"https://openalex.org/W1968227643","doi":"https://doi.org/10.1111/apha.12006","mag":"1968227643","pmid":"https://pubmed.ncbi.nlm.nih.gov/22958452"},"language":"en","primary_location":{"id":"doi:10.1111/apha.12006","doi":"https://doi.org/10.1111/apha.12006","is_oa":false,"landing_page_url":"https://doi.org/10.1111/apha.12006","pdf_url":null,"source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113586114","display_name":"James Harmsworth King","orcid":"https://orcid.org/0009-0007-6541-3753","observed_orcids":["https://orcid.org/0009-0007-6541-3753"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. H. King","raw_affiliation_strings":["Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623320","display_name":"Yanmin Zhang","orcid":"https://orcid.org/0000-0001-7580-4693","observed_orcids":["https://orcid.org/0000-0001-7580-4693"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Y. Zhang","raw_affiliation_strings":["Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107094272","display_name":"Ming Lei","orcid":"https://orcid.org/0000-0002-0928-341X","observed_orcids":["https://orcid.org/0000-0002-0928-341X","https://orcid.org/0000-0002-1153-4791"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Lei","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000336640","display_name":"Andrew A. Grace","orcid":"https://orcid.org/0000-0002-0686-215X","observed_orcids":["https://orcid.org/0000-0002-0686-215X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. A. Grace","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018416044","display_name":"Christopher L.-H. Huang","orcid":"https://orcid.org/0000-0001-9553-6112","observed_orcids":["https://orcid.org/0000-0001-9553-6112"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. L.\u2010H. Huang","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge, UK","Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009468759","display_name":"James A. Fraser","orcid":"https://orcid.org/0000-0002-6505-1883","observed_orcids":["https://orcid.org/0000-0002-6505-1883"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. A. Fraser","raw_affiliation_strings":["Physiological Laboratory, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009468759"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":5150,"currency":"USD","value_usd":5150},"apc_paid":null,"fwci":3.3019,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.92850721,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"207","issue":"2","first_page":"308","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.7160000205039978},{"id":"https://openalex.org/keywords/atrial-arrhythmias","display_name":"atrial arrhythmias","score":0.9800000190734863},{"id":"https://openalex.org/keywords/delayed-afterdepolarizations","display_name":"delayed afterdepolarizations","score":0.9020000100135803},{"id":"https://openalex.org/keywords/interatrial-conduction-delay","display_name":"interatrial conduction delay","score":0.8220000267028809},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/diastolic-calcium-release","display_name":"diastolic calcium release","score":0.7950000166893005},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mouse-heart","display_name":"mouse heart","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C190712762","wikidata":"https://www.wikidata.org/wiki/Q18031341","display_name":"Ryanodine receptor 2","level":4,"score":0.6755459904670715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6480562090873718},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6039927005767822},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5731651782989502},{"id":"https://openalex.org/C179253579","wikidata":"https://www.wikidata.org/wiki/Q6276958","display_name":"Nerve conduction velocity","level":2,"score":0.505394458770752},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.44690248370170593},{"id":"https://openalex.org/C155730078","wikidata":"https://www.wikidata.org/wiki/Q2898697","display_name":"Afterdepolarization","level":4,"score":0.4393242299556732},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.4392128884792328},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4222312569618225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4160909354686737},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.40919291973114014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3809741735458374},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.19312047958374023},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.09965026378631592}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/apha.12006","doi":"https://doi.org/10.1111/apha.12006","is_oa":false,"landing_page_url":"https://doi.org/10.1111/apha.12006","pdf_url":null,"source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},{"id":"pmid:22958452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22958452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8787611345","display_name":"Cardiac electrophysiological homeostasis","funder_award_id":"BB/F023863/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1494989930","https://openalex.org/W1519251370","https://openalex.org/W1844360423","https://openalex.org/W1964105691","https://openalex.org/W1965331909","https://openalex.org/W1967365407","https://openalex.org/W1967658895","https://openalex.org/W1969120794","https://openalex.org/W1979173978","https://openalex.org/W1980232262","https://openalex.org/W1983905571","https://openalex.org/W1993589792","https://openalex.org/W1994221403","https://openalex.org/W1995144854","https://openalex.org/W1996439106","https://openalex.org/W2003284163","https://openalex.org/W2003552474","https://openalex.org/W2011041203","https://openalex.org/W2027970873","https://openalex.org/W2033891898","https://openalex.org/W2035832108","https://openalex.org/W2037008570","https://openalex.org/W2050824263","https://openalex.org/W2051822015","https://openalex.org/W2056203122","https://openalex.org/W2057046598","https://openalex.org/W2064757035","https://openalex.org/W2069884282","https://openalex.org/W2078680195","https://openalex.org/W2081524260","https://openalex.org/W2087116178","https://openalex.org/W2095741885","https://openalex.org/W2097457646","https://openalex.org/W2106487550","https://openalex.org/W2109054243","https://openalex.org/W2110333181","https://openalex.org/W2115336034","https://openalex.org/W2117971943","https://openalex.org/W2122162791","https://openalex.org/W2122638396","https://openalex.org/W2131624747","https://openalex.org/W2140687234","https://openalex.org/W2146464796","https://openalex.org/W2152754701","https://openalex.org/W2153869748","https://openalex.org/W2162079750","https://openalex.org/W2165211571","https://openalex.org/W2169930818","https://openalex.org/W2171404421","https://openalex.org/W2273697055","https://openalex.org/W2313203550","https://openalex.org/W2546425606","https://openalex.org/W3023558172","https://openalex.org/W4251202920","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2046723387","https://openalex.org/W2140687234","https://openalex.org/W1970983144","https://openalex.org/W2056741592","https://openalex.org/W2229704428","https://openalex.org/W2095741885","https://openalex.org/W2074643515","https://openalex.org/W2128499270","https://openalex.org/W3080089693","https://openalex.org/W2124523737"],"abstract_inverted_index":{"AIM:":[0],"RyR2":[1],"mutations":[2],"are":[3],"associated":[4,216],"with":[5,150,217],"catecholaminergic":[6],"polymorphic":[7],"tachycardia,":[8],"a":[9,41,60,82,161,198],"condition":[10],"characterized":[11],"by":[12],"ventricular":[13],"and":[14,34,53,99,109,124,130,148,170,182,197],"atrial":[15,22,223],"arrhythmias.":[16],"The":[17],"present":[18],"experiments":[19],"investigate":[20],"the":[21,67,167],"electrophysiology":[23],"of":[24,70,113,133,143,164,172],"homozygotic":[25],"murine":[26],"RyR2-P2328S":[27],"(RyR2(S/S))":[28],"hearts":[29],"for":[30,35],"ectopic":[31,100,136],"triggering":[32],"events":[33],"conduction":[36,88,104],"abnormalities":[37],"that":[38,188],"might":[39,208],"provide":[40],"re-entrant":[42],"substrate.":[43],"METHODS:":[44],"Electrocardiograph":[45],"recordings":[46],"were":[47,139,178],"made":[48],"from":[49],"regularly":[50],"stimulated":[51],"RyR2(S/S)":[52,92,156,181,203],"wild":[54],"type":[55],"(WT)":[56],"hearts,":[57],"perfused":[58],"using":[59],"novel":[61],"modified":[62],"Langendorff":[63],"preparation.":[64],"This":[65],"permitted":[66],"simultaneous":[68],"use":[69],"either":[71],"floating":[72],"intracellular":[73,190],"microelectrodes":[74],"to":[75,85,211],"measure":[76,86],"action":[77],"potential":[78],"(AP)":[79],"parameters,":[80],"or":[81],"multielectrode":[83],"array":[84],"epicardial":[87,107],"velocity":[89],"(CV).":[90],"RESULTS:":[91],"showed":[93,158],"frequent":[94],"sustained":[95],"tachyarrhythmias,":[96],"delayed":[97],"afterdepolarizations":[98],"APs,":[101],"increased":[102],"interatrial":[103,128,168],"delays,":[105],"reduced":[106,110],"CVs":[108,129],"maximum":[111],"rates":[112],"AP":[114,122,125],"depolarization":[115],"((dV/dt)(max)),":[116],"despite":[117],"similar":[118,179,206],"effective":[119],"refractory":[120],"periods,":[121],"durations":[123],"amplitudes.":[126],"Effective":[127],"(dV/dt)(max)":[131,171],"values":[132],"APs":[134,144,174],"following":[135,145],"(S2)":[137],"stimulation":[138,147],"lower":[140],"than":[141],"those":[142],"regular":[146],"decreased":[149],"shortening":[151],"S1S2":[152,165],"intervals.":[153],"However,":[154],"although":[155],"atria":[157],"arrhythmias":[159,177],"over":[160],"wider":[162],"range":[163],"intervals,":[166],"CV":[169],"S2":[173],"provoking":[175],"such":[176,221],"in":[180,202,213],"WT.":[183],"CONCLUSIONS:":[184],"These":[185],"results":[186],"suggest":[187],"abnormal":[189],"Ca(2+)":[191,219],"homoeostasis":[192],"produces":[193],"both":[194],"arrhythmic":[195,200],"triggers":[196],"slow-conducting":[199],"substrate":[201],"atria.":[204],"A":[205],"mechanism":[207],"also":[209],"contribute":[210],"arrhythmogenesis":[212],"other":[214],"conditions,":[215],"diastolic":[218],"release,":[220],"as":[222],"fibrillation.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}