{"id":"https://openalex.org/W1968220216","doi":"https://doi.org/10.1038/nrm2526","title":"Turning anti-ageing genes against cancer","display_name":"Turning anti-ageing genes against cancer","publication_year":2008,"publication_date":"2008-10-23","ids":{"openalex":"https://openalex.org/W1968220216","doi":"https://doi.org/10.1038/nrm2526","mag":"1968220216","pmid":"https://pubmed.ncbi.nlm.nih.gov/18946478"},"language":"en","primary_location":{"id":"doi:10.1038/nrm2526","doi":"https://doi.org/10.1038/nrm2526","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrm2526","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073120806","display_name":"Valter Daniel Longo","orcid":"https://orcid.org/0000-0002-0946-7534","observed_orcids":["https://orcid.org/0000-0002-0946-7534"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Valter D. Longo","raw_affiliation_strings":["Andrus Gerontology Center, Molecular and Computational Biology Department, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089-0191, USA. vlongo@usc.edu","University of Southern California, Los Angeles, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrus Gerontology Center, Molecular and Computational Biology Department, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089-0191, USA. vlongo@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California, Los Angeles, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079559642","display_name":"Michael R. Lieber","orcid":"https://orcid.org/0000-0003-3700-6345","observed_orcids":["https://orcid.org/0000-0003-3700-6345"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Lieber","raw_affiliation_strings":["the Molecular and Computational Biology Department and the Norris Cancer Center, Valter D. Longo and Michael R. Lieber are at the Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089\u20130191, USA.,","University of Southern California, Los Angeles, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Molecular and Computational Biology Department and the Norris Cancer Center, Valter D. Longo and Michael R. Lieber are at the Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089\u20130191, USA.,","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"University of Southern California, Los Angeles, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012398734","display_name":"Jan Vijg","orcid":"https://orcid.org/0000-0002-8457-9595","observed_orcids":["https://orcid.org/0000-0002-8457-9595"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Vijg","raw_affiliation_strings":["the Molecular and Computational Biology Department and the Norris Cancer Center, Valter D. Longo and Michael R. Lieber are at the Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089\u20130191, USA.,","University of Southern California, Los Angeles, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Molecular and Computational Biology Department and the Norris Cancer Center, Valter D. Longo and Michael R. Lieber are at the Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089\u20130191, USA.,","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"University of Southern California, Los Angeles, United States","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073120806"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.417,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.27906977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"11","first_page":"903","last_page":"910"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.9010000228881836},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.718999981880188},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.972000002861023},{"id":"https://openalex.org/keywords/chromosomal-damage","display_name":"chromosomal damage","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7789999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6655370593070984},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6344694495201111},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6012826561927795},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5562748312950134},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5434496998786926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5190937519073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4880882501602173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4695485234260559},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4653374254703522},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46378031373023987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45117560029029846},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4482908844947815},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44330644607543945},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.412160187959671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3445127606391907},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3022935390472412},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.20795106887817383}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrm2526","doi":"https://doi.org/10.1038/nrm2526","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrm2526","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},{"id":"pmid:18946478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18946478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Molecular cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3357368892","display_name":"Hormonal signals, genome integrity and longevity","funder_award_id":"R01AG020438","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4406720077","display_name":null,"funder_award_id":"ES110444","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4896149597","display_name":"Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in","funder_award_id":"R01AG020642","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7195483794","display_name":"Chronological Age-Dependent Genomic Instability in Yeast","funder_award_id":"R01AG025135","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8093415072","display_name":"DNA Repair, Mutations and Cellular Aging","funder_award_id":"P01AG017242","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8940708990","display_name":"Mechanism and Regulation of Human Nonhomologous DNA End Joining","funder_award_id":"R01CA100504","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1487552431","https://openalex.org/W1521853181","https://openalex.org/W1552426876","https://openalex.org/W1631908837","https://openalex.org/W1877188956","https://openalex.org/W1909120931","https://openalex.org/W1965488058","https://openalex.org/W1975693251","https://openalex.org/W1977144229","https://openalex.org/W1979562269","https://openalex.org/W1981148605","https://openalex.org/W1982146148","https://openalex.org/W1982395176","https://openalex.org/W1983880033","https://openalex.org/W1985425785","https://openalex.org/W1987297410","https://openalex.org/W1987738803","https://openalex.org/W2002407831","https://openalex.org/W2002622198","https://openalex.org/W2003832896","https://openalex.org/W2006764478","https://openalex.org/W2009315366","https://openalex.org/W2015010022","https://openalex.org/W2028181126","https://openalex.org/W2031143675","https://openalex.org/W2033872641","https://openalex.org/W2037526941","https://openalex.org/W2037921221","https://openalex.org/W2042716686","https://openalex.org/W2043966795","https://openalex.org/W2046387526","https://openalex.org/W2047683380","https://openalex.org/W2049009766","https://openalex.org/W2049842278","https://openalex.org/W2049871469","https://openalex.org/W2054059225","https://openalex.org/W2057418848","https://openalex.org/W2058357830","https://openalex.org/W2062629127","https://openalex.org/W2063078301","https://openalex.org/W2066519654","https://openalex.org/W2069625482","https://openalex.org/W2072712477","https://openalex.org/W2075622596","https://openalex.org/W2077612844","https://openalex.org/W2077685680","https://openalex.org/W2078030859","https://openalex.org/W2078710187","https://openalex.org/W2081490071","https://openalex.org/W2082302044","https://openalex.org/W2084054222","https://openalex.org/W2087085892","https://openalex.org/W2087404852","https://openalex.org/W2096452837","https://openalex.org/W2098337864","https://openalex.org/W2102140136","https://openalex.org/W2111843196","https://openalex.org/W2113402231","https://openalex.org/W2115525455","https://openalex.org/W2118685612","https://openalex.org/W2121371748","https://openalex.org/W2121585544","https://openalex.org/W2124855460","https://openalex.org/W2125840439","https://openalex.org/W2128557797","https://openalex.org/W2133469432","https://openalex.org/W2135257384","https://openalex.org/W2136212424","https://openalex.org/W2142205521","https://openalex.org/W2151566575","https://openalex.org/W2152185756","https://openalex.org/W2159979637","https://openalex.org/W2163489514","https://openalex.org/W2165209574","https://openalex.org/W2169677856","https://openalex.org/W2170138349","https://openalex.org/W2174263354","https://openalex.org/W2315987042","https://openalex.org/W3021964391","https://openalex.org/W4205141611"],"related_works":["https://openalex.org/W2003411862","https://openalex.org/W2038055963","https://openalex.org/W2234725098","https://openalex.org/W2044395802","https://openalex.org/W2019960169","https://openalex.org/W2058357830","https://openalex.org/W7095461496","https://openalex.org/W2029007558","https://openalex.org/W1966801582","https://openalex.org/W4415849430"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
