{"id":"https://openalex.org/W1968219092","doi":"https://doi.org/10.1007/s00284-009-9457-0","title":"Oral Administration of Live Bifidobacterium Substrains Isolated from Centenarians Enhances Intestinal Function in Mice","display_name":"Oral Administration of Live Bifidobacterium Substrains Isolated from Centenarians Enhances Intestinal Function in Mice","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W1968219092","doi":"https://doi.org/10.1007/s00284-009-9457-0","mag":"1968219092","pmid":"https://pubmed.ncbi.nlm.nih.gov/19701668"},"language":"en","primary_location":{"id":"doi:10.1007/s00284-009-9457-0","doi":"https://doi.org/10.1007/s00284-009-9457-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00284-009-9457-0","pdf_url":null,"source":{"id":"https://openalex.org/S2248630","display_name":"Current Microbiology","issn_l":"0343-8651","issn":["0343-8651","1432-0991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1968219092"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108255590","display_name":"Haiying Yang","orcid":"https://orcid.org/0009-0005-2592-2188","observed_orcids":["https://orcid.org/0009-0005-2592-2188","https://orcid.org/0009-0007-5516-743X"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Yang","raw_affiliation_strings":["College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103937393","display_name":"Aiping Liu","orcid":"https://orcid.org/0000-0003-3789-4450","observed_orcids":["https://orcid.org/0000-0003-3789-4450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aiping Liu","raw_affiliation_strings":["MengNiu Diary Company, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MengNiu Diary Company, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447336","display_name":"Ming Zhang","orcid":"https://orcid.org/0000-0003-4574-9704","observed_orcids":["https://orcid.org/0000-0003-4574-9704"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Zhang","raw_affiliation_strings":["College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049319073","display_name":"Salam Adnan Ibrahim","orcid":"https://orcid.org/0000-0001-5395-9993","observed_orcids":["https://orcid.org/0000-0001-5395-9993"]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salam A. Ibrahim","raw_affiliation_strings":["Food Microbiology and Biotechnology Laboratory, North Carolina A & T State University, Greensboro, NC, USA","Food Microbiology and Biotechnology Laboratory, North Carolina A & T State University, Greensboro, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Microbiology and Biotechnology Laboratory, North Carolina A & T State University, Greensboro, NC, USA","institution_ids":["https://openalex.org/I35777872"]},{"raw_affiliation_string":"Food Microbiology and Biotechnology Laboratory, North Carolina A & T State University, Greensboro, USA","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054512416","display_name":"Zhihua Pang","orcid":"https://orcid.org/0000-0003-3583-4112","observed_orcids":["https://orcid.org/0000-0003-3583-4112"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Pang","raw_affiliation_strings":["College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102202069","display_name":"Xiaojing Leng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Leng","raw_affiliation_strings":["College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070473172","display_name":"Fazheng Ren","orcid":"https://orcid.org/0000-0001-6250-0754","observed_orcids":["https://orcid.org/0000-0001-6250-0754","https://orcid.org/0000-0001-6774-300X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fazheng Ren","raw_affiliation_strings":["Key Laboratory of Functional Dairy, College of Food Science & Nutritional Engineering, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Dairy, College of Food Science & Nutritional Engineering, Beijing, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070473172"],"corresponding_institution_ids":[],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":2.8158,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.87899562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"4","first_page":"439","last_page":"445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifidobacterium-adolescentis","display_name":"Bifidobacterium adolescentis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bifidobacterium-longum","display_name":"Bifidobacterium longum","score":1.0},{"id":"https://openalex.org/keywords/centenarians","display_name":"centenarians","score":0.7440000176429749},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7419999837875366},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/intestinal-morphology","display_name":"intestinal morphology","score":0.7670000195503235},{"id":"https://openalex.org/keywords/villus-height","display_name":"villus height","score":0.746999979019165},{"id":"https://openalex.org/keywords/crypt-depth","display_name":"crypt depth","score":0.9850000143051147},{"id":"https://openalex.org/keywords/villus-crypt-ratio","display_name":"villus:crypt ratio","score":0.9380000233650208},{"id":"https://openalex.org/keywords/intestinal-immune-barrier","display_name":"intestinal immune barrier","score":0.7680000066757202},{"id":"https://openalex.org/keywords/duodenum","display_name":"duodenum","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.8794606924057007},{"id":"https://openalex.org/C2776809568","wikidata":"https://www.wikidata.org/wiki/Q134955","display_name":"Duodenum","level":2,"score":0.7951184511184692},{"id":"https://openalex.org/C2776996202","wikidata":"https://www.wikidata.org/wiki/Q4904768","display_name":"Bifidobacterium longum","level":5,"score":0.7375731468200684},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.7112730741500854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6959683895111084},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5653825998306274},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.5491459965705872},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.45997998118400574},{"id":"https://openalex.org/C2781456731","wikidata":"https://www.wikidata.org/wiki/Q868506","display_name":"Intestinal villus","level":3,"score":0.4521021842956543},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.4265737533569336},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4191340506076813},{"id":"https://openalex.org/C2781357212","wikidata":"https://www.wikidata.org/wiki/Q5275608","display_name":"Digestion (alchemy)","level":2,"score":0.41247931122779846},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4099820852279663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3827768564224243},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2880669832229614},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2733176648616791},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.1693786382675171},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.16473940014839172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14921411871910095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13707047700881958},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.10163477063179016},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00284-009-9457-0","doi":"https://doi.org/10.1007/s00284-009-9457-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00284-009-9457-0","pdf_url":null,"source":{"id":"https://openalex.org/S2248630","display_name":"Current Microbiology","issn_l":"0343-8651","issn":["0343-8651","1432-0991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Microbiology","raw_type":"journal-article"},{"id":"pmid:19701668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19701668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1971402960","https://openalex.org/W1977307485","https://openalex.org/W1988752472","https://openalex.org/W2002612262","https://openalex.org/W2016030094","https://openalex.org/W2018463927","https://openalex.org/W2018841243","https://openalex.org/W2019965911","https://openalex.org/W2033734515","https://openalex.org/W2035203332","https://openalex.org/W2044619586","https://openalex.org/W2044710722","https://openalex.org/W2056010853","https://openalex.org/W2072344970","https://openalex.org/W2074513558","https://openalex.org/W2086690500","https://openalex.org/W2105568939","https://openalex.org/W2113000633","https://openalex.org/W2115792069","https://openalex.org/W2120031697","https://openalex.org/W2122034415","https://openalex.org/W2128797170","https://openalex.org/W2146928367","https://openalex.org/W2153969635","https://openalex.org/W2294158949","https://openalex.org/W2305372638","https://openalex.org/W2332649630"],"related_works":["https://openalex.org/W2016316746","https://openalex.org/W2002578996","https://openalex.org/W2386750917","https://openalex.org/W1995243191","https://openalex.org/W2390131109","https://openalex.org/W4386087040","https://openalex.org/W2770320828","https://openalex.org/W7095965954","https://openalex.org/W2088589553","https://openalex.org/W4394768662"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}