{"id":"https://openalex.org/W1968200878","doi":"https://doi.org/10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","title":"Inhibitors of mitochondrial ATP production at the time of compaction improve development of in vitro produced porcine embryos","display_name":"Inhibitors of mitochondrial ATP production at the time of compaction improve development of in vitro produced porcine embryos","publication_year":2000,"publication_date":"2000-12-04","ids":{"openalex":"https://openalex.org/W1968200878","doi":"https://doi.org/10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","mag":"1968200878","pmid":"https://pubmed.ncbi.nlm.nih.gov/11144218"},"language":"en","primary_location":{"id":"doi:10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","doi":"https://doi.org/10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015759451","display_name":"Zolt\u00e1n Mach\u00e1ty","orcid":"https://orcid.org/0000-0001-9021-1706","observed_orcids":["https://orcid.org/0000-0001-9021-1706"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Mach\u00e1ty","raw_affiliation_strings":["Department of Animal Sciences, University of Missouri-Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Missouri-Columbia, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004353622","display_name":"Jeremy G. Thompson","orcid":"https://orcid.org/0000-0003-4941-7731","observed_orcids":["https://orcid.org/0000-0003-4941-7731"]},"institutions":[{"id":"https://openalex.org/I41125697","display_name":"AgResearch","ror":"https://ror.org/0124gwh94","country_code":"NZ","type":"government","lineage":["https://openalex.org/I41125697","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Jeremy G. Thompson","raw_affiliation_strings":["AgResearch Raukura Research Centre, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AgResearch Raukura Research Centre, Hamilton, New Zealand","institution_ids":["https://openalex.org/I41125697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089586570","display_name":"Lalantha R. Abeydeera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lalantha R. Abeydeera","raw_affiliation_strings":["Department of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109804719","display_name":"Billy Neil Day","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Billy N. Day","raw_affiliation_strings":["Department of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024184340","display_name":"Randall S. Prather","orcid":"https://orcid.org/0000-0002-6012-4035","observed_orcids":["https://orcid.org/0000-0002-6012-4035"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall S. Prather","raw_affiliation_strings":["Department of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri","Randall S. Prather, 162 Animal Science Research Center, University of Missouri\u2010Columbia, Columbia, Missouri 65211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Missouri-Columbia, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Randall S. Prather, 162 Animal Science Research Center, University of Missouri\u2010Columbia, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024184340"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":2.3464,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.87477735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"1","first_page":"39","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-embryos","display_name":"porcine embryos","score":0.6909999847412109},{"id":"https://openalex.org/keywords/in-vitro-embryo-production","display_name":"in vitro embryo production","score":0.921999990940094},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthesis","display_name":"mitochondrial ATP production","score":0.7829999923706055},{"id":"https://openalex.org/keywords/oxidative-phosphorylation-inhibition","display_name":"oxidative phosphorylation inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sodium-azide","display_name":"sodium azide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/2-4-dinitrophenol","display_name":"2,4-dinitrophenol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/low-oxygen-culture","display_name":"low oxygen culture","score":0.6380000114440918},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.7680000066757202},{"id":"https://openalex.org/keywords/nuclear-number","display_name":"nuclear number","score":0.7419999837875366},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.43700000643730164},{"id":"https://openalex.org/keywords/conceptus-development","display_name":"conceptus development","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8486531376838684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7784029841423035},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.7579737305641174},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6869896650314331},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.6663740277290344},{"id":"https://openalex.org/C2781417787","wikidata":"https://www.wikidata.org/wiki/Q407577","display_name":"Sodium azide","level":2,"score":0.6568381786346436},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5418217778205872},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5348208546638489},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5305557250976562},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4721115827560425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3394627273082733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2578147053718567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001757","descriptor_name":"Blastomeres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014475","descriptor_name":"Uncoupling Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019297","descriptor_name":"2,4-Dinitrophenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019810","descriptor_name":"Sodium Azide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","doi":"https://doi.org/10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1098-2795(200101)58:1<39::aid-mrd6>3.0.co;2-b","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:11144218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11144218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.4300000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1616590414","display_name":"MARKERS FOR PREDICTING DEVELOPMENTAL COMPETENCE","funder_award_id":"5u01hd034588-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G558285672","display_name":null,"funder_award_id":"HD34588","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W297918892","https://openalex.org/W1502488818","https://openalex.org/W1968480824","https://openalex.org/W1973289124","https://openalex.org/W1987285745","https://openalex.org/W2011827930","https://openalex.org/W2014090828","https://openalex.org/W2016814232","https://openalex.org/W2018901577","https://openalex.org/W2027543816","https://openalex.org/W2028592182","https://openalex.org/W2039228769","https://openalex.org/W2048481959","https://openalex.org/W2048808612","https://openalex.org/W2066519414","https://openalex.org/W2068985723","https://openalex.org/W2085849919","https://openalex.org/W2095457746","https://openalex.org/W2098586307","https://openalex.org/W2116304454","https://openalex.org/W2124763811","https://openalex.org/W2129533522","https://openalex.org/W2145957764","https://openalex.org/W2164666014","https://openalex.org/W2166713989","https://openalex.org/W2285972583","https://openalex.org/W2303712512","https://openalex.org/W2460806824","https://openalex.org/W3093408246","https://openalex.org/W6784624214"],"related_works":["https://openalex.org/W2098586307","https://openalex.org/W2018901577","https://openalex.org/W1981890623","https://openalex.org/W7120673376","https://openalex.org/W4403425390","https://openalex.org/W7151100201","https://openalex.org/W1967274983","https://openalex.org/W2156936191","https://openalex.org/W2071747112","https://openalex.org/W1893069105"],"abstract_inverted_index":{"The":[0,40,89,199],"relationship":[1],"between":[2],"partial":[3],"inhibition":[4,204],"of":[5,45,61,66,95,141,205],"mitochondrial":[6,206],"ATP":[7,35,207],"production":[8,36,208],"during":[9],"the":[10,46,59,79,85,93,107,111,129,139,147,182],"peri-compaction":[11],"stage":[12,131],"and":[13,145],"porcine":[14,22,212],"embryonic":[15,213],"development":[16,214],"was":[17,119],"studied.":[18],"In":[19],"vitro":[20],"produced":[21],"compact":[23,158],"morulae":[24,159],"were":[25,126,154,160,185],"cultured":[26],"for":[27,211],"two":[28],"days":[29],"under":[30,71],"conditions":[31,42],"that":[32,202],"should":[33],"inhibit":[34],"via":[37],"oxidative":[38,54,67],"phosphorylation.":[39],"culture":[41,47],"included":[43],"supplementation":[44],"medium":[48],"with":[49],"sodium":[50],"azide":[51],"(NaN3),":[52],"an":[53,64,163],"phosphorylation":[55],"inhibitor;":[56],"incubation":[57,70],"in":[58,84,92,116,138,146,162,215],"presence":[60,94],"2,4-dinitrophenol":[62],"(DNP),":[63],"uncoupler":[65],"phosphorylation;":[68],"or":[69,171],"5%":[72,166],"O2":[73],"concentration.":[74],"NaN3":[75,170],"(10-20":[76],"microM)":[77],"increased":[78],"average":[80,112,148],"nuclear":[81,113,149],"number":[82,114,150],"found":[83,115],"resulting":[86],"blastocysts":[87,100,118],"(P<0.05).":[88],"embryos":[90,109,184],"developed":[91],"100":[96],"microM":[97],"DNP":[98,172],"formed":[99],"at":[101],"a":[102],"significantly":[103],"higher":[104,121],"incidence":[105],"than":[106],"control":[108],"(P<0.001);":[110],"these":[117,124],"also":[120,155],"(P<0.005).":[122],"When":[123],"treatments":[125],"applied":[127],"from":[128],"1-cell":[130],"they":[132],"proved":[133],"to":[134,187],"be":[135],"detrimental.":[136],"Elevations":[137],"frequency":[140],"blastocyst":[142,152],"formation":[143],"(P<0.05),":[144],"per":[151],"(P<0.001)":[153],"measured":[156],"when":[157],"incubated":[161],"atmosphere":[164],"containing":[165],"vs.":[167],"20%":[168],"O2.":[169],"did":[173],"not":[174],"have":[175],"negative":[176],"effects":[177],"on":[178],"long":[179],"term":[180],"development:":[181],"treated":[183],"able":[186],"form":[188],"viable":[189],"conceptuses":[190],"by":[191],"day":[192],"30":[193],"after":[194],"being":[195],"transferred":[196],"into":[197],"recipients.":[198],"data":[200],"indicate":[201],"transient":[203],"is":[209],"advantageous":[210],"vitro.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
