{"id":"https://openalex.org/W1968199641","doi":"https://doi.org/10.1371/journal.pone.0069788","title":"Low Temperature Mitigates Cardia Bifida in Zebrafish Embryos","display_name":"Low Temperature Mitigates Cardia Bifida in Zebrafish Embryos","publication_year":2013,"publication_date":"2013-07-26","ids":{"openalex":"https://openalex.org/W1968199641","doi":"https://doi.org/10.1371/journal.pone.0069788","mag":"1968199641","pmid":"https://pubmed.ncbi.nlm.nih.gov/23922799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724881"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0069788","doi":"https://doi.org/10.1371/journal.pone.0069788","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0069788","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069788&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069788&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045338514","display_name":"Che-Yi Lin","orcid":"https://orcid.org/0000-0002-7719-2325","observed_orcids":["https://orcid.org/0000-0002-7719-2325"]},"institutions":[{"id":"https://openalex.org/I153512688","display_name":"National Taiwan Ocean University","ror":"https://ror.org/03bvvnt49","country_code":"TW","type":"education","lineage":["https://openalex.org/I153512688"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Che-Yi Lin","raw_affiliation_strings":["Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan","institution_ids":["https://openalex.org/I153512688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007058419","display_name":"Chengchen Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14403649","display_name":"University of Wisconsin\u2013River Falls","ror":"https://ror.org/02ep9vf55","country_code":"US","type":"education","lineage":["https://openalex.org/I14403649"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng-Chen Huang","raw_affiliation_strings":["Department of Biology, University of Wisconsin-River Falls, River Falls, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Wisconsin-River Falls, River Falls, Wisconsin, United States of America","institution_ids":["https://openalex.org/I14403649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112370901","display_name":"Wen\u2010Der Wang","orcid":"https://orcid.org/0000-0003-2647-2658","observed_orcids":["https://orcid.org/0000-0003-2647-2658"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Der Wang","raw_affiliation_strings":["Graduate Institute of Agricultural Biotechnology, National Chiayi University, Chiayi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Agricultural Biotechnology, National Chiayi University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018386605","display_name":"Chung\u2010Der Hsiao","orcid":"https://orcid.org/0000-0002-6398-8672","observed_orcids":["https://orcid.org/0000-0002-6398-8672"]},"institutions":[{"id":"https://openalex.org/I151221077","display_name":"Chung Yuan Christian University","ror":"https://ror.org/02w8ws377","country_code":"TW","type":"education","lineage":["https://openalex.org/I151221077"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Der Hsiao","raw_affiliation_strings":["Department of Bioscience Technology, Chung Yuang Christian University, Chungli, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience Technology, Chung Yuang Christian University, Chungli, Taiwan","institution_ids":["https://openalex.org/I151221077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042905323","display_name":"Ching\u2010Feng Cheng","orcid":"https://orcid.org/0000-0003-0104-0146","observed_orcids":["https://orcid.org/0000-0003-0104-0146"]},"institutions":[{"id":"https://openalex.org/I4210122745","display_name":"Buddhist Tzu Chi General Hospital","ror":"https://ror.org/037r57b62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210122745"]},{"id":"https://openalex.org/I4210123378","display_name":"Hualien Tzu Chi Medical Center","ror":"https://ror.org/030k6vb67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210123378"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Feng Cheng","raw_affiliation_strings":["Department of Pediatrics, Tzu Chi General Hospital, Hualien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tzu Chi General Hospital, Hualien, Taiwan","institution_ids":["https://openalex.org/I4210122745","https://openalex.org/I4210123378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037563363","display_name":"Yi\u2010Ting Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ting Wu","raw_affiliation_strings":["Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048524684","display_name":"Yu\u2010Fen Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Fen Lu","raw_affiliation_strings":["Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037983599","display_name":"Sheng\u2010Ping L. Hwang","orcid":"https://orcid.org/0000-0003-2554-3821","observed_orcids":["https://orcid.org/0000-0003-2554-3821"]},"institutions":[{"id":"https://openalex.org/I153512688","display_name":"National Taiwan Ocean University","ror":"https://ror.org/03bvvnt49","country_code":"TW","type":"education","lineage":["https://openalex.org/I153512688"]},{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Sheng-Ping L. Hwang","raw_affiliation_strings":["Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan","Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan","institution_ids":["https://openalex.org/I153512688"]},{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037983599"],"corresponding_institution_ids":["https://openalex.org/I153512688","https://openalex.org/I4210132902"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.05752748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"7","first_page":"e69788","last_page":"e69788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-tube-formation","display_name":"heart tube formation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cardiomyocyte-migration","display_name":"cardiomyocyte migration","score":0.8489999771118164},{"id":"https://openalex.org/keywords/low-temperature","display_name":"low temperature","score":0.5720000267028809},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7860000133514404},{"id":"https://openalex.org/keywords/fibronectin-1","display_name":"FN1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tenascin-c","display_name":"tenascin-C","score":0.9929999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8420000076293945},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.968999981880188},{"id":"https://openalex.org/keywords/gata5","display_name":"GATA5","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bon","display_name":"Bon","score":0.8330000042915344},{"id":"https://openalex.org/keywords/somitogenesis","display_name":"somitogenesis","score":0.906000018119812},{"id":"https://openalex.org/keywords/zebrafish-heart-development","display_name":"zebrafish heart development","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7059352993965149},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5112855434417725},{"id":"https://openalex.org/C70749424","wikidata":"https://www.wikidata.org/wiki/Q2431958","display_name":"Animal sexual behaviour","level":3,"score":0.41477638483047485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39383959770202637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3028979003429413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26675426959991455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17008864879608154},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07945603132247925},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0069788","doi":"https://doi.org/10.1371/journal.pone.0069788","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0069788","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069788&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2727366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3724881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23922799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23922799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bcda68f13e9045ef92492e79f82b908c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bcda68f13e9045ef92492e79f82b908c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 7, p e69788 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/757152","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Low_Temperature_Mitigates_Cardia_Bifida_in_Zebrafish_Embryos_/757152","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0069788","doi":"https://doi.org/10.1371/journal.pone.0069788","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0069788","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069788&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3006427632","display_name":null,"funder_award_id":"NSC99","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968199641.pdf","grobid_xml":"https://content.openalex.org/works/W1968199641.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1510083318","https://openalex.org/W1516458390","https://openalex.org/W1519072726","https://openalex.org/W1586710766","https://openalex.org/W1677560495","https://openalex.org/W1853102624","https://openalex.org/W1857560941","https://openalex.org/W1920249815","https://openalex.org/W1920707660","https://openalex.org/W1964506754","https://openalex.org/W1968830698","https://openalex.org/W1983393196","https://openalex.org/W1992979409","https://openalex.org/W2001339111","https://openalex.org/W2011757341","https://openalex.org/W2016939574","https://openalex.org/W2018762863","https://openalex.org/W2018912455","https://openalex.org/W2023760000","https://openalex.org/W2025436695","https://openalex.org/W2038850974","https://openalex.org/W2044793751","https://openalex.org/W2053807467","https://openalex.org/W2060660326","https://openalex.org/W2061223357","https://openalex.org/W2063220206","https://openalex.org/W2069835893","https://openalex.org/W2070677984","https://openalex.org/W2074213253","https://openalex.org/W2074907054","https://openalex.org/W2088076775","https://openalex.org/W2088703231","https://openalex.org/W2090733040","https://openalex.org/W2096561521","https://openalex.org/W2102084748","https://openalex.org/W2107914421","https://openalex.org/W2108539496","https://openalex.org/W2116039818","https://openalex.org/W2117132433","https://openalex.org/W2125349610","https://openalex.org/W2133465414","https://openalex.org/W2135223800","https://openalex.org/W2138291240","https://openalex.org/W2143149809","https://openalex.org/W2146927398","https://openalex.org/W2148989249","https://openalex.org/W2155259978","https://openalex.org/W2155634762","https://openalex.org/W2157614363","https://openalex.org/W2164786712","https://openalex.org/W2188422153","https://openalex.org/W2414876679"],"related_works":["https://openalex.org/W2117120673","https://openalex.org/W2067449619","https://openalex.org/W3139737332","https://openalex.org/W4406316103","https://openalex.org/W2039943198","https://openalex.org/W2009964296","https://openalex.org/W3120795641","https://openalex.org/W2904231598","https://openalex.org/W1992979409","https://openalex.org/W1964159423"],"abstract_inverted_index":{"The":[0,143],"coordinated":[1],"migration":[2],"of":[3,9,30,33,42,55,83,92,108,145,172,176,187,201,219],"bilateral":[4,81],"cardiomyocytes":[5],"and":[6,28,70,95,114,134,157,223,225,233],"the":[7,10,31,80,84,89,122,170,177,185,199,217,220],"formation":[8,36,91],"cardiac":[11,34],"cone":[12,35],"are":[13,235],"essential":[14],"for":[15],"heart":[16,221],"tube":[17,222],"formation.":[18],"We":[19],"investigated":[20],"gene":[21,149],"regulatory":[22],"mechanisms":[23],"involved":[24],"in":[25,37,132,208],"myocardial":[26],"migration,":[27],"regulation":[29],"timing":[32],"zebrafish":[38,43],"embryos.":[39,210],"Through":[40],"screening":[41],"treated":[44],"with":[45,51,63],"ethylnitrosourea,":[46],"we":[47],"isolated":[48],"a":[49,52,191],"mutant":[50],"hypomorphic":[53],"allele":[54,65],"mil":[56],"(s1pr2)/edg5,":[57],"called":[58],"s1pr2(as10)":[59,109,209],"(as10).":[60],"Mutant":[61],"embryos":[62,110,123],"this":[64],"expressed":[66],"less":[67],"mil/edg5":[68],"mRNA":[69,156],"exhibited":[71],"cardia":[72,106,136,166,206],"bifida":[73,107,137,167,207],"prior":[74],"to":[75,100],"28":[76],"hours":[77],"post-fertilization.":[78],"Although":[79],"hearts":[82],"mutants":[85],"gradually":[86],"fused":[87],"together,":[88],"resulting":[90],"two":[93],"atria":[94],"one":[96],"tightly-packed":[97],"ventricle":[98],"failed":[99],"support":[101],"normal":[102,115],"blood":[103],"circulation.":[104],"Interestingly,":[105],"could":[111,117],"be":[112,118],"rescued":[113],"circulation":[116],"restored":[119],"by":[120,168],"incubating":[121],"at":[124,140],"low":[125,163,202],"temperature":[126,164,203,215],"(22.5\u00b0C).":[127],"Rescue":[128],"was":[129],"also":[130],"observed":[131],"gata5":[133],"bon":[135],"morphants":[138],"raised":[139],"22.5":[141],"\u00b0C.":[142],"use":[144],"DNA":[146],"microarrays,":[147],"digital":[148],"expression":[150,171],"analyses,":[151],"loss-of-function,":[152],"as":[153,155],"well":[154],"protein":[158],"rescue":[159],"experiments,":[160],"revealed":[161],"that":[162,214,226],"mitigates":[165],"regulating":[169],"genes":[173,229],"encoding":[174],"components":[175],"extracellular":[178,227],"matrix":[179,228],"(fibronectin":[180,230],"1,":[181,231],"tenascin-c,":[182],"tenascin-w).":[183],"Furthermore,":[184],"addition":[186],"N-acetyl":[188],"cysteine":[189],"(NAC),":[190],"reactive":[192],"oxygen":[193],"species":[194],"(ROS)":[195],"scavenger,":[196],"significantly":[197],"decreased":[198],"effect":[200],"on":[204],"mitigating":[205],"Our":[211],"study":[212],"reveals":[213],"coordinates":[216],"development":[218],"somitogenesis,":[224],"tenascin-c":[232],"tenascin-w)":[234],"involved.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}