{"id":"https://openalex.org/W1968189252","doi":"https://doi.org/10.1002/jps.22457","title":"An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir","display_name":"An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir","publication_year":2010,"publication_date":"2010-12-29","ids":{"openalex":"https://openalex.org/W1968189252","doi":"https://doi.org/10.1002/jps.22457","mag":"1968189252","pmid":"https://pubmed.ncbi.nlm.nih.gov/21491455"},"language":"en","primary_location":{"id":"doi:10.1002/jps.22457","doi":"https://doi.org/10.1002/jps.22457","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.22457","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012870282","display_name":"Rob ter Heine","orcid":"https://orcid.org/0000-0003-2185-8201","observed_orcids":["https://orcid.org/0000-0003-2185-8201"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rob ter Heine","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands. rob@terheine.nl","Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands. rob@terheine.nl","institution_ids":["https://openalex.org/I2802065108"]},{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064255458","display_name":"Robert A.B. van Waterschoot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert A.B. Van Waterschoot","raw_affiliation_strings":["Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061094080","display_name":"Ron J. Keizer","orcid":"https://orcid.org/0000-0002-2460-7056","observed_orcids":["https://orcid.org/0000-0002-2460-7056"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ron J. Keizer","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos H. Beijnen","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045217576","display_name":"Alfred H. Schinkel","orcid":"https://orcid.org/0000-0002-4215-8602","observed_orcids":["https://orcid.org/0000-0002-4215-8602"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alfred H. Schinkel","raw_affiliation_strings":["Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010531755","display_name":"Alwin D. R. Huitema","orcid":"https://orcid.org/0000-0003-1939-4639","observed_orcids":["https://orcid.org/0000-0003-1939-4639"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alwin D.R. Huitema","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012870282"],"corresponding_institution_ids":["https://openalex.org/I2802065108"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":1.0494,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.708731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"100","issue":"6","first_page":"2508","last_page":"2515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lopinavir","display_name":"lopinavir","score":1.0},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.6460000276565552},{"id":"https://openalex.org/keywords/intestinal-first-pass-metabolism","display_name":"intestinal first-pass metabolism","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hepatic-first-pass-metabolism","display_name":"hepatic first-pass metabolism","score":0.8159999847412109},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hiv-protease-inhibitors","display_name":"HIV protease inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6669999957084656},{"id":"https://openalex.org/keywords/systemic-clearance","display_name":"systemic clearance","score":0.6399999856948853},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.9470604658126831},{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.9370409250259399},{"id":"https://openalex.org/C2781392899","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Lopinavir/ritonavir","level":5,"score":0.8075839281082153},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.7991580963134766},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6488436460494995},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6468896865844727},{"id":"https://openalex.org/C11824378","wikidata":"https://www.wikidata.org/wiki/Q5014970","display_name":"CYP3A","level":4,"score":0.5138914585113525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5078094601631165},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5067110657691956},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4533287286758423},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4333673417568207},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4293443262577057},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.31468862295150757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2338544726371765},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.19964668154716492},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.18505942821502686},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.16511166095733643},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.12425926327705383},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.11127534508705139},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10290640592575073},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.22457","doi":"https://doi.org/10.1002/jps.22457","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.22457","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:21491455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21491455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1600472674","https://openalex.org/W1965479467","https://openalex.org/W1969991318","https://openalex.org/W1980720468","https://openalex.org/W2018325257","https://openalex.org/W2066464642","https://openalex.org/W2109313097","https://openalex.org/W2112857740","https://openalex.org/W2150549589","https://openalex.org/W2158884589"],"related_works":["https://openalex.org/W1600472674","https://openalex.org/W2102233898","https://openalex.org/W1981936023","https://openalex.org/W2035609812","https://openalex.org/W1865374355","https://openalex.org/W2104051674","https://openalex.org/W2123781057","https://openalex.org/W2018325257","https://openalex.org/W2106308893","https://openalex.org/W1984277888"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
