{"id":"https://openalex.org/W1968185291","doi":"https://doi.org/10.1016/s0169-328x(97)00277-5","title":"Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells","display_name":"Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1968185291","doi":"https://doi.org/10.1016/s0169-328x(97)00277-5","mag":"1968185291","pmid":"https://pubmed.ncbi.nlm.nih.gov/9473604"},"language":"en","primary_location":{"id":"doi:10.1016/s0169-328x(97)00277-5","doi":"https://doi.org/10.1016/s0169-328x(97)00277-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-328x(97)00277-5","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103431574","display_name":"Su Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su Wu","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111957779","display_name":"Rebecca A. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A Wright","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033923316","display_name":"Pamela K. Rockey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela K Rockey","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112389272","display_name":"Stanley G. Burgett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley G Burgett","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002931824","display_name":"Jeffrey S. Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S Arnold","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024983118","display_name":"Paul R. Rosteck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R Rosteck","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113583844","display_name":"Bryan G. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan G Johnson","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055799927","display_name":"Darryle D. Schoepp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darryle D Schoepp","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001357470","display_name":"Rama M. Belagaje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rama M Belagaje","raw_affiliation_strings":["Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technology and Protein Division, Drop code 0424, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001357470"],"corresponding_institution_ids":["https://openalex.org/I168537998"],"apc_list":null,"apc_paid":null,"fwci":4.0057,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.94828197,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"53","issue":"1-2","first_page":"88","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/group-iii-metabotropic-glutamate-receptors","display_name":"group III metabotropic glutamate receptors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mglur4","display_name":"mGluR4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mglur7","display_name":"mGluR7","score":1.0},{"id":"https://openalex.org/keywords/mglur8","display_name":"mGluR8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-cloning","display_name":"receptor cloning","score":0.5339999794960022},{"id":"https://openalex.org/keywords/camp-production","display_name":"cAMP production","score":0.5249999761581421},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.8119999766349792},{"id":"https://openalex.org/keywords/l-ap4","display_name":"L-AP4","score":0.9520000219345093},{"id":"https://openalex.org/keywords/l-ccg-i","display_name":"L-CCG-I","score":0.9890000224113464},{"id":"https://openalex.org/keywords/agonist-potency","display_name":"agonist potency","score":0.7049999833106995},{"id":"https://openalex.org/keywords/antagonist-potency","display_name":"antagonist potency","score":0.8939999938011169},{"id":"https://openalex.org/keywords/subtype-selectivity","display_name":"subtype selectivity","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.8239880204200745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6794296503067017},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6316590905189514},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.5781311988830566},{"id":"https://openalex.org/C116592611","wikidata":"https://www.wikidata.org/wiki/Q21113349","display_name":"Metabotropic glutamate receptor 4","level":5,"score":0.5753151774406433},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.526461660861969},{"id":"https://openalex.org/C119128870","wikidata":"https://www.wikidata.org/wiki/Q4859538","display_name":"Metabotropic glutamate receptor 2","level":5,"score":0.47392019629478455},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.45147716999053955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43294423818588257},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3375239670276642}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018690","descriptor_name":"Excitatory Amino Acid Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0169-328x(97)00277-5","doi":"https://doi.org/10.1016/s0169-328x(97)00277-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-328x(97)00277-5","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},{"id":"pmid:9473604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9473604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research. Molecular brain research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W70976387","https://openalex.org/W1487123995","https://openalex.org/W1491106180","https://openalex.org/W1503789839","https://openalex.org/W1564717701","https://openalex.org/W1823231128","https://openalex.org/W1965372133","https://openalex.org/W1968150938","https://openalex.org/W1970596941","https://openalex.org/W1972183007","https://openalex.org/W1983197885","https://openalex.org/W2000756368","https://openalex.org/W2013067874","https://openalex.org/W2019105891","https://openalex.org/W2023811880","https://openalex.org/W2033745315","https://openalex.org/W2039894841","https://openalex.org/W2040456704","https://openalex.org/W2043166209","https://openalex.org/W2043529380","https://openalex.org/W2045859529","https://openalex.org/W2046208200","https://openalex.org/W2046291479","https://openalex.org/W2048392691","https://openalex.org/W2050577658","https://openalex.org/W2052115812","https://openalex.org/W2058591676","https://openalex.org/W2063461600","https://openalex.org/W2066439059","https://openalex.org/W2066439205","https://openalex.org/W2068761941","https://openalex.org/W2069434795","https://openalex.org/W2070027885","https://openalex.org/W2072793434","https://openalex.org/W2085887265","https://openalex.org/W2085988072","https://openalex.org/W2100040827","https://openalex.org/W2111062311","https://openalex.org/W2129108032","https://openalex.org/W2149201522","https://openalex.org/W2161584310","https://openalex.org/W2283440353","https://openalex.org/W2399928535","https://openalex.org/W2404806481","https://openalex.org/W2417578687","https://openalex.org/W2918074113","https://openalex.org/W2950192423","https://openalex.org/W6695585300"],"related_works":["https://openalex.org/W2149201522","https://openalex.org/W2010291532","https://openalex.org/W1987749248","https://openalex.org/W2057776188","https://openalex.org/W1965312515","https://openalex.org/W2069434795","https://openalex.org/W2404806481","https://openalex.org/W2092653529","https://openalex.org/W1723449","https://openalex.org/W1999817051"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}