{"id":"https://openalex.org/W1968180307","doi":"https://doi.org/10.1055/s-2007-967693","title":"Immunosuppressive therapy with everolimus improves renal function in heart transplant recipients with chronic renal failure","display_name":"Immunosuppressive therapy with everolimus improves renal function in heart transplant recipients with chronic renal failure","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1968180307","doi":"https://doi.org/10.1055/s-2007-967693","mag":"1968180307"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-967693","doi":"https://doi.org/10.1055/s-2007-967693","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-967693","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043375934","display_name":"Uwe Fuchs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800536013","display_name":"Heart and Diabetes Center North Rhine-Westphalia","ror":"https://ror.org/02wndzd81","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I2800536013"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U Fuchs","raw_affiliation_strings":["HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany","institution_ids":["https://openalex.org/I2800536013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057907241","display_name":"Gero Tenderich","orcid":"https://orcid.org/0000-0003-2269-9054","observed_orcids":["https://orcid.org/0000-0003-2269-9054"]},"institutions":[{"id":"https://openalex.org/I2800536013","display_name":"Heart and Diabetes Center North Rhine-Westphalia","ror":"https://ror.org/02wndzd81","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I2800536013"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Tenderich","raw_affiliation_strings":["HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany","institution_ids":["https://openalex.org/I2800536013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061446773","display_name":"Armin Zittermann","orcid":"https://orcid.org/0000-0001-6085-6554","observed_orcids":["https://orcid.org/0000-0001-6085-6554"]},"institutions":[{"id":"https://openalex.org/I2800536013","display_name":"Heart and Diabetes Center North Rhine-Westphalia","ror":"https://ror.org/02wndzd81","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I2800536013"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Zittermann","raw_affiliation_strings":["HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany","institution_ids":["https://openalex.org/I2800536013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024367865","display_name":"W. Deyerling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800536013","display_name":"Heart and Diabetes Center North Rhine-Westphalia","ror":"https://ror.org/02wndzd81","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I2800536013"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Deyerling","raw_affiliation_strings":["HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany","institution_ids":["https://openalex.org/I2800536013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001550422","display_name":"Uwe Schulz","orcid":"https://orcid.org/0000-0003-0362-8103","observed_orcids":["https://orcid.org/0000-0003-0362-8103"]},"institutions":[{"id":"https://openalex.org/I2800536013","display_name":"Heart and Diabetes Center North Rhine-Westphalia","ror":"https://ror.org/02wndzd81","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I2800536013"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U Schulz","raw_affiliation_strings":["HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany","institution_ids":["https://openalex.org/I2800536013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052634484","display_name":"Reiner Koerfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800536013","display_name":"Heart and Diabetes Center North Rhine-Westphalia","ror":"https://ror.org/02wndzd81","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I2800536013"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Koerfer","raw_affiliation_strings":["HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HDZ NRW, Thorax- und Kardiovaskularchirurgie, Bad Oeynhausen, Germany","institution_ids":["https://openalex.org/I2800536013"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800536013"],"apc_list":null,"apc_paid":null,"fwci":0.3321,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66275108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"S 1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":1.0},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.828000009059906},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.722000002861023},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7250000238418579},{"id":"https://openalex.org/keywords/peripheral-edema","display_name":"peripheral edema","score":0.9200000166893005},{"id":"https://openalex.org/keywords/allograft-vasculopathy","display_name":"allograft vasculopathy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cardiac-rejection","display_name":"cardiac rejection","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9761126041412354},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.9541065692901611},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6637383103370667},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6144213080406189},{"id":"https://openalex.org/C2992666275","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Renal transplant","level":3,"score":0.5978720188140869},{"id":"https://openalex.org/C2908822073","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Impaired renal function","level":3,"score":0.5848281383514404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5243587493896484},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5036196112632751},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5027737617492676},{"id":"https://openalex.org/C2993356106","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal failure","level":2,"score":0.49411633610725403},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.4817235767841339},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4246438145637512},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.4108029305934906},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.39051511883735657},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35263383388519287},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3281363844871521}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-967693","doi":"https://doi.org/10.1055/s-2007-967693","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-967693","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2889881147","https://openalex.org/W2065960652","https://openalex.org/W2328872699","https://openalex.org/W1997245814","https://openalex.org/W2598380616","https://openalex.org/W2323350227","https://openalex.org/W7212574340","https://openalex.org/W2054171816","https://openalex.org/W2042805889","https://openalex.org/W2063614274"],"abstract_inverted_index":{"Aims:":[0],"Everolimus,":[1],"a":[2,62,156,228],"novel":[3],"immunosuppressive":[4],"agent,":[5],"may":[6,11],"improve":[7,216],"renal":[8,23,31,45,72,211],"function":[9,32,218],"and":[10,33,52,80,119,122,136,192,235],"also":[12],"suppress":[13],"allograft":[14],"cardiac":[15,131,203],"vasculopathy":[16],"in":[17,39,205,219,231],"heart":[18,40,67,206],"transplant":[19,41,68,207],"recipients":[20,42,69,208],"with":[21,43,70,90,209],"chronic":[22,44,71,210],"failure.":[24],"This":[25],"study":[26],"was":[27],"aimed":[28],"to":[29,49,83,125,164,215,227],"examine":[30],"the":[34,75,223],"occurrence":[35],"of":[36,65,93,99,111,159,172,240],"adverse":[37,181],"events":[38],"failure":[46,73,212],"after":[47,123],"conversion":[48,124],"everolimus.":[50,84,95,126],"Patients":[51],"methods:":[53],"Since":[54],"January":[55],"1,":[56],"2004,":[57],"we":[58],"have":[59],"switched":[60],"over":[61],"total":[63],"number":[64],"118":[66],"from":[74,139],"calcineurin":[76],"inhibitors":[77],"CSA":[78,100],"(N=75)":[79],"TAC":[81,102],"(N=43)":[82],"All":[85],"patients":[86],"were":[87,103,174],"initially":[88],"treated":[89],"daily":[91],"doses":[92],"1.5mg":[94],"In":[96],"parallel,":[97],"dosages":[98],"or":[101],"reduced":[104],"by":[105,143,148],"50%.":[106],"We":[107],"analysed":[108],"serum":[109,232],"levels":[110,166,171],"creatinine,":[112],"BUN,":[113],"thrombocytes,":[114],"erythrocytes,":[115],"leucocytes,":[116],"Cholesterol":[117],"(HDL/LDL)":[118],"triglycerides":[120,233],"before":[121],"Results:":[127],"During":[128],"follow-up,":[129],"no":[130],"rejections":[132,204],"occurred.":[133],"Both,":[134],"creatinine":[135],"BUN":[137],"decreased":[138],"t0":[140],"until":[141],"t6":[142],"approximately":[144],"11%.":[145],"HDL-cholesterol":[146],"increased":[147],"more":[149],"than":[150],"40%":[151],"during":[152],"follow-up.":[153],"LDL-cholesterol":[154],"showed":[155],"transient":[157],"increase":[158,230],"11%":[160],"but":[161],"had":[162],"returned":[163],"baseline":[165],"at":[167,177],"t6.":[168,178],"Blood":[169],"trough":[170],"everolimus":[173,200],"5.1":[175],"ng/l":[176],"The":[179],"main":[180],"effects":[182],"were:":[183],"peripheral":[184],"edema":[185,190],"(12.71%),":[186],"dyspnea":[187],"(8.47%)":[188],"lingual":[189],"(5.93%)":[191],"diarrhoe":[193],"(4.24%).":[194],"Conclusions:":[195],"Our":[196],"data":[197],"indicate":[198],"that":[199],"effectively":[201],"inhibits":[202],"is":[213],"able":[214],"kidney":[217],"these":[220],"patients,":[221],"improves":[222],"HDL/LDL":[224],"ratio,":[225],"leads":[226],"massive":[229],"levels,":[234],"shows":[236],"an":[237],"expected":[238],"spectrum":[239],"side":[241],"effects.":[242]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}