{"id":"https://openalex.org/W1968173997","doi":"https://doi.org/10.1074/jbc.m702329200","title":"Role of AMP Kinase and PPAR\u03b4 in the Regulation of Lipid and Glucose Metabolism in Human Skeletal Muscle","display_name":"Role of AMP Kinase and PPAR\u03b4 in the Regulation of Lipid and Glucose Metabolism in Human Skeletal Muscle","publication_year":2007,"publication_date":"2007-05-12","ids":{"openalex":"https://openalex.org/W1968173997","doi":"https://doi.org/10.1074/jbc.m702329200","mag":"1968173997","pmid":"https://pubmed.ncbi.nlm.nih.gov/17500064"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m702329200","doi":"https://doi.org/10.1074/jbc.m702329200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m702329200","pdf_url":"http://www.jbc.org/article/S0021925817473121/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925817473121/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068281541","display_name":"David Kramer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"David Kitz Kr\u00e4mer","raw_affiliation_strings":["Department of Molecular Medicine, Karolinska Institutet, S-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Karolinska Institutet, S-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014267586","display_name":"Lubna Al\u2010Khalili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lubna Al-Khalili","raw_affiliation_strings":["Department of Karolinska Institutet, S-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Karolinska Institutet, S-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025693848","display_name":"Bruno Guigas","orcid":"https://orcid.org/0000-0002-8856-5799","observed_orcids":["https://orcid.org/0000-0002-8856-5799"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bruno Guigas","raw_affiliation_strings":["Hormone and Metabolic Research Unit, School of Medicine, Universite\u0301 Catholique de Louvain and Institute of Cellular Pathology, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormone and Metabolic Research Unit, School of Medicine, Universite\u0301 Catholique de Louvain and Institute of Cellular Pathology, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100301226","display_name":"Ying Leng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ying Leng","raw_affiliation_strings":["Department of Karolinska Institutet, S-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Karolinska Institutet, S-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041424157","display_name":"Pablo M. Garc\u00eda-Rov\u00e9s","orcid":"https://orcid.org/0000-0002-8371-2067","observed_orcids":["https://orcid.org/0000-0002-8371-2067","https://orcid.org/0000-0001-9826-1740"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Pablo M. Garcia-Roves","raw_affiliation_strings":["Molecular Medicine and Surgery and, Karolinska Institutet, S-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine and Surgery and, Karolinska Institutet, S-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068081328","display_name":"Anna Krook","orcid":"https://orcid.org/0000-0002-0891-0258","observed_orcids":["https://orcid.org/0000-0002-0891-0258"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anna Krook","raw_affiliation_strings":["Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden and","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068081328"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.9842,"has_fulltext":true,"cited_by_count":184,"citation_normalized_percentile":{"value":0.9784992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"282","issue":"27","first_page":"19313","last_page":"19320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gw501516","display_name":"GW501516","score":0.9509999752044678},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.921999990940094},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.824999988079071},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.8420000076293945},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.9779999852180481},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fabp3","display_name":"FABP3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/carnitine-palmitoyltransferase-1","display_name":"carnitine palmitoyltransferase 1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-kinase-4","display_name":"PDK4","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ppardelta-agonist","display_name":"PPAR\u03b4 agonist","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8951989412307739},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.717567503452301},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.6344939470291138},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.589771032333374},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5464758276939392},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5427340269088745},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.5367279052734375},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5358570218086243},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.5311720967292786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49350178241729736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4696701467037201},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.46883314847946167},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.4288908541202545},{"id":"https://openalex.org/C2778179274","wikidata":"https://www.wikidata.org/wiki/Q18030433","display_name":"PDK4","level":4,"score":0.4138500392436981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.395906925201416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3526860773563385},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3240482211112976},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3205100893974304},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.31838107109069824},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.256630003452301},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.21858936548233032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000263","descriptor_name":"Adenylate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047494","descriptor_name":"PPAR delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047494","descriptor_name":"PPAR delta","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m702329200","doi":"https://doi.org/10.1074/jbc.m702329200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m702329200","pdf_url":"http://www.jbc.org/article/S0021925817473121/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17500064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17500064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Clinical Trial"},{"id":"pmh:oai:diposit.ub.edu:2445/177394","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/177394","pdf_url":"http://hdl.handle.net/2445/177394","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Ci\u00e8ncies Fisiol\u00f2giques)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:37511","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/37511","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, Vol. 282, no. 27, p. 19313-19320 (2007)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m702329200","doi":"https://doi.org/10.1074/jbc.m702329200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m702329200","pdf_url":"http://www.jbc.org/article/S0021925817473121/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G292827090","display_name":null,"funder_award_id":"LSHMCT-2004-005272","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6442517181","display_name":null,"funder_award_id":"LSHM-CT-2004-512013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320311298","display_name":"Stiftelsen Forska Utan Djurf\u00f6rs\u00f6k","ror":"https://ror.org/038937755"},{"id":"https://openalex.org/F4320312316","display_name":"Petrus och Augusta Hedlunds Stiftelse","ror":"https://ror.org/00ay00v02"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324308","display_name":"Sveriges L\u00e4karf\u00f6rbund","ror":"https://ror.org/04hdh0n29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968173997.pdf","grobid_xml":"https://content.openalex.org/works/W1968173997.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1527476004","https://openalex.org/W1965621923","https://openalex.org/W1969384498","https://openalex.org/W1969554900","https://openalex.org/W1971082641","https://openalex.org/W1978213355","https://openalex.org/W1980963186","https://openalex.org/W1982027543","https://openalex.org/W1987391633","https://openalex.org/W1987435442","https://openalex.org/W1987601141","https://openalex.org/W1994470496","https://openalex.org/W1994572553","https://openalex.org/W1996885736","https://openalex.org/W2004861205","https://openalex.org/W2007304772","https://openalex.org/W2012834939","https://openalex.org/W2016060556","https://openalex.org/W2021142676","https://openalex.org/W2024254257","https://openalex.org/W2032552649","https://openalex.org/W2034618205","https://openalex.org/W2039212784","https://openalex.org/W2047399305","https://openalex.org/W2053765200","https://openalex.org/W2054066779","https://openalex.org/W2055135733","https://openalex.org/W2056416937","https://openalex.org/W2060600856","https://openalex.org/W2062613627","https://openalex.org/W2071580797","https://openalex.org/W2087727741","https://openalex.org/W2093201995","https://openalex.org/W2094964407","https://openalex.org/W2097205737","https://openalex.org/W2099483235","https://openalex.org/W2113328569","https://openalex.org/W2117833492","https://openalex.org/W2128557965","https://openalex.org/W2144834841","https://openalex.org/W2146788074","https://openalex.org/W2170590212","https://openalex.org/W2171821929","https://openalex.org/W2403578638"],"related_works":["https://openalex.org/W2094652231","https://openalex.org/W2144834841","https://openalex.org/W2121031147","https://openalex.org/W1973123665","https://openalex.org/W2120736359","https://openalex.org/W2056416937","https://openalex.org/W1982027543","https://openalex.org/W2129266853","https://openalex.org/W1481084828","https://openalex.org/W2166491773"],"abstract_inverted_index":{"The":[0],"peroxisome":[1],"proliferator-activated":[2],"receptor":[3],"(PPAR)delta":[4],"has":[5,21],"been":[6,22],"implicated":[7],"in":[8,14,32,56,129,160,180,196,202],"the":[9,43,60,110,115,126,154,177,190],"regulation":[10],"of":[11,19,35,76,112,118,156],"lipid":[12,161],"metabolism":[13,162,198],"skeletal":[15,57,204],"muscle.":[16,58],"Furthermore,":[17,121],"activation":[18],"PPARdelta":[20,44,105,140,191],"proposed":[23],"to":[24,64],"improve":[25],"insulin":[26],"sensitivity":[27],"and":[28,52,87,92,94,141,165,199,209,211],"reduce":[29],"glucose":[30,54,95,181],"levels":[31],"animal":[33],"models":[34],"type":[36],"2":[37],"diabetes.":[38],"We":[39],"recently":[40],"demonstrated":[41,103,175],"that":[42,74,104,125,151,176],"agonist":[45,192],"GW501516":[46,83,113,135,152,193],"activates":[47],"AMP-activated":[48],"protein":[49],"kinase":[50],"(AMPK)":[51],"stimulates":[53],"uptake":[55,182],"However,":[59],"underlying":[61],"mechanism":[62],"remains":[63],"be":[65],"clearly":[66],"identified.":[67],"In":[68,188],"this":[69],"study,":[70],"we":[71,101,122,148,172],"first":[72],"confirmed":[73],"incubation":[75],"primary":[77],"cultured":[78],"human":[79,203],"muscle":[80,205],"cells":[81,206],"with":[82,144],"induced":[84,133],"AMPK":[85,184],"phosphorylation":[86],"increased":[88],"fatty":[89,119,130],"acid":[90,131],"transport":[91],"oxidation":[93,132],"uptake.":[96],"Using":[97],"small":[98],"interfering":[99],"RNA,":[100],"have":[102,123,173],"expression":[106,155,201],"is":[107,136],"required":[108],"for":[109],"effect":[111],"on":[114,138],"intracellular":[116],"accumulation":[117],"acids.":[120],"shown":[124],"subsequent":[127],"increase":[128,179],"by":[134,167,207],"dependent":[137],"both":[139],"AMPK.":[142],"Concomitant":[143],"these":[145],"metabolic":[146],"changes,":[147],"provide":[149],"evidence":[150],"increases":[153],"key":[157],"genes":[158],"involved":[159],"(FABP3,":[163],"CPT1,":[164],"PDK4)":[166],"a":[168],"PPARdelta-dependent":[169],"mechanism.":[170],"Finally,":[171],"also":[174],"GW501516-mediated":[178],"requires":[183],"but":[185],"not":[186],"PPARdelta.":[187],"conclusion,":[189],"promotes":[194],"changes":[195],"lipid/glucose":[197],"gene":[200],"PPARdelta-":[208],"AMPK-dependent":[210],"-independent":[212],"mechanisms.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
