{"id":"https://openalex.org/W19681685","doi":null,"title":"Platelet-neutrophil interactions. Possible relevance in the pathogenesis of thrombosis and inflammation.","display_name":"Platelet-neutrophil interactions. Possible relevance in the pathogenesis of thrombosis and inflammation.","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W19681685","mag":"19681685","pmid":"https://pubmed.ncbi.nlm.nih.gov/1820986"},"language":"en","primary_location":{"id":"pmid:1820986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1820986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011054972","display_name":"Gianfranco Bazzoni","orcid":"https://orcid.org/0000-0001-9093-6395","observed_orcids":["https://orcid.org/0000-0001-9093-6395"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Bazzoni","raw_affiliation_strings":["Laboratorio di Biologia Vascolare, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Biologia Vascolare, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003887782","display_name":"Elisabetta Dejana","orcid":"https://orcid.org/0000-0002-0007-0426","observed_orcids":["https://orcid.org/0000-0002-0007-0426","https://orcid.org/0000-0003-0309-7154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Dejana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008917048","display_name":"Aldo Del Maschio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Del Maschio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6887,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.92725109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76","issue":"6","first_page":"491","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-neutrophil-interaction","display_name":"neutrophil-platelet interaction","score":0.996999979019165},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/platelet-derived-mediators","display_name":"platelet-derived mediators","score":0.7239999771118164},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8277581334114075},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7611201405525208},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7166415452957153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6557972431182861},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6315823197364807},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.5280338525772095},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.42750221490859985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36631232500076294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09872311353683472}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1820986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1820986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"mag:19681685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1820986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1981140145","https://openalex.org/W2017863178","https://openalex.org/W2032799014","https://openalex.org/W2041106374","https://openalex.org/W2041297343","https://openalex.org/W2043796909","https://openalex.org/W2048620043","https://openalex.org/W2066598080","https://openalex.org/W2070290651","https://openalex.org/W2070594534","https://openalex.org/W2080161895","https://openalex.org/W2086553752","https://openalex.org/W2092330718","https://openalex.org/W2093921553","https://openalex.org/W2104024374","https://openalex.org/W2127424354","https://openalex.org/W2139738640","https://openalex.org/W2143225980","https://openalex.org/W2149476088","https://openalex.org/W2156785179","https://openalex.org/W6646977141","https://openalex.org/W6652463405","https://openalex.org/W6653499615"],"related_works":["https://openalex.org/W2769853730","https://openalex.org/W1986840683","https://openalex.org/W2953857717","https://openalex.org/W2091259372","https://openalex.org/W2952547435","https://openalex.org/W2981775679","https://openalex.org/W4210537777","https://openalex.org/W4309310277","https://openalex.org/W2444648474","https://openalex.org/W7099179285"],"abstract_inverted_index":{"Evidence":[0],"indicates":[1],"that":[2],"complex":[3],"interactions":[4,76,115],"occur":[5],"between":[6],"platelets":[7,14,22,50],"and":[8,41,51,57,64,69,121],"neutrophils.":[9],"Mediators":[10],"released":[11],"by":[12],"activated":[13],"may":[15,23,36,60,77],"act":[16],"as":[17],"stimuli":[18],"for":[19],"neutrophils,":[20,29,52],"but":[21],"also":[24],"limit":[25],"neutrophil":[26,96],"activation.":[27],"Similarly,":[28],"depending":[30],"upon":[31],"their":[32],"degree":[33],"of":[34,43,67,74,95,113,119],"activation,":[35],"bring":[37],"about":[38],"both":[39],"enhancement":[40],"inhibition":[42],"platelet":[44,105],"responses.":[45],"The":[46],"elaborate":[47],"cross-talk":[48],"among":[49],"cells":[53],"involved":[54,90],"in":[55,82,91,116],"hemostatic":[56],"phlogistic":[58],"reactions,":[59],"condition":[61],"the":[62,65,88,92,100,110,117],"development":[63],"course":[66],"thrombotic":[68],"inflammatory":[70],"diseases;":[71],"therefore,":[72],"modulation":[73,94],"platelet-neutrophil":[75],"represent":[78],"a":[79],"therapeutic":[80],"target":[81],"these":[83,114],"conditions.":[84],"In":[85],"this":[86],"review,":[87],"mediators":[89],"platelet-dependent":[93],"activation":[97],"and,":[98],"conversely,":[99],"mechanisms":[101],"whereby":[102],"neutrophils":[103],"modify":[104],"responses":[106],"are":[107],"described.":[108],"Moreover,":[109],"possible":[111],"relevance":[112],"pathogenesis":[118],"thrombosis":[120],"inflammation":[122],"is":[123],"discussed.":[124]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
