{"id":"https://openalex.org/W1968151387","doi":"https://doi.org/10.1007/s12272-008-1127-4","title":"Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine","display_name":"Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1968151387","doi":"https://doi.org/10.1007/s12272-008-1127-4","mag":"1968151387","pmid":"https://pubmed.ncbi.nlm.nih.gov/18277615"},"language":"en","primary_location":{"id":"doi:10.1007/s12272-008-1127-4","doi":"https://doi.org/10.1007/s12272-008-1127-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12272-008-1127-4","pdf_url":null,"source":{"id":"https://openalex.org/S119001223","display_name":"Archives of Pharmacal Research","issn_l":"0253-6269","issn":["0253-6269","1976-3786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pharmacal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hye-Won Chae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Won Chae","raw_affiliation_strings":["National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081852574","display_name":"In\u2010Wha Kim","orcid":"https://orcid.org/0000-0003-4976-3343","observed_orcids":["https://orcid.org/0000-0003-4976-3343"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In-Wha Kim","raw_affiliation_strings":["National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022053152","display_name":"Hyo\u2010Eon Jin","orcid":"https://orcid.org/0000-0002-1292-5508","observed_orcids":["https://orcid.org/0000-0002-1292-5508"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyo-Eon Jin","raw_affiliation_strings":["National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078895940","display_name":"Dae\u2010Duk Kim","orcid":"https://orcid.org/0000-0003-0093-3874","observed_orcids":["https://orcid.org/0000-0003-0093-3874"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Duk Kim","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012894904","display_name":"Suk\u2010Jae Chung","orcid":"https://orcid.org/0000-0001-8576-8470","observed_orcids":["https://orcid.org/0000-0001-8576-8470"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk-Jae Chung","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091547688","display_name":"Chang\u2010Koo Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Chang-Koo Shim","raw_affiliation_strings":["National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Laboratory for Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091547688"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":0.9207,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.75944786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"1","first_page":"103","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ion-pair-complexation","display_name":"ion-pair complexation","score":0.828000009059906},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/taurodeoxycholate","display_name":"taurodeoxycholic acid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/organic-cation-transport","display_name":"organic cation transport","score":0.8100000023841858},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.906000018119812},{"id":"https://openalex.org/keywords/efflux-transport","display_name":"efflux transport","score":0.7210000157356262},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/llc-pk1-cells","display_name":"LLC-PK1 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apical-to-basolateral-transport","display_name":"apical-to-basolateral transport","score":0.824999988079071},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibitors","display_name":"P-glycoprotein inhibitors","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.7549999952316284},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.9900000095367432},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/secretory-transport","display_name":"secretory transport","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.8643293976783752},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8205884099006653},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.6158180236816406},{"id":"https://openalex.org/C189613389","wikidata":"https://www.wikidata.org/wiki/Q70479817","display_name":"Organic cation transport proteins","level":4,"score":0.6093779802322388},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.5920360684394836},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.5344746708869934},{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.5007021427154541},{"id":"https://openalex.org/C30448527","wikidata":"https://www.wikidata.org/wiki/Q10384227","display_name":"Mediated transport","level":3,"score":0.49061647057533264},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.47737833857536316},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.4477602243423462},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42688053846359253},{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.4122202694416046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38283273577690125},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3444277048110962},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.26564469933509827},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2584065794944763},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09672504663467407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08106940984725952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013657","descriptor_name":"Taurodeoxycholic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018374","descriptor_name":"LLC-PK1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s12272-008-1127-4","doi":"https://doi.org/10.1007/s12272-008-1127-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12272-008-1127-4","pdf_url":null,"source":{"id":"https://openalex.org/S119001223","display_name":"Archives of Pharmacal Research","issn_l":"0253-6269","issn":["0253-6269","1976-3786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pharmacal Research","raw_type":"journal-article"},{"id":"pmid:18277615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18277615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pharmacal research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.661.2047","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.661.2047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.snupharm.ac.kr/ddkim/erp/erpmenus/professor_thesis/upLoadFiles/%EC%B1%84%ED%98%9C%EC%9B%90-APR.pdf?origin%3Dpublication_detail","raw_type":"text"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/224641","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/224641","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W71151985","https://openalex.org/W112476650","https://openalex.org/W1496617617","https://openalex.org/W1522767714","https://openalex.org/W1898201908","https://openalex.org/W1915172695","https://openalex.org/W1964348907","https://openalex.org/W1973229029","https://openalex.org/W1979196526","https://openalex.org/W1983418243","https://openalex.org/W1984454344","https://openalex.org/W1990432963","https://openalex.org/W1992630127","https://openalex.org/W2000643206","https://openalex.org/W2065139224","https://openalex.org/W2070387753","https://openalex.org/W2076359557","https://openalex.org/W2084486503","https://openalex.org/W2091571409","https://openalex.org/W2099686459","https://openalex.org/W2131309880","https://openalex.org/W2155832132","https://openalex.org/W2176464622","https://openalex.org/W2219907588","https://openalex.org/W2914994574"],"related_works":["https://openalex.org/W2091571409","https://openalex.org/W1496617617","https://openalex.org/W2353845396","https://openalex.org/W2181391334","https://openalex.org/W2049181806","https://openalex.org/W2146653565","https://openalex.org/W1966271190","https://openalex.org/W2252339098","https://openalex.org/W168122303","https://openalex.org/W2176464622"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
