{"id":"https://openalex.org/W1968144530","doi":"https://doi.org/10.1161/01.cir.92.11.3172","title":"Hyperlipidemia and Coronary Disease","display_name":"Hyperlipidemia and Coronary Disease","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W1968144530","doi":"https://doi.org/10.1161/01.cir.92.11.3172","mag":"1968144530","pmid":"https://pubmed.ncbi.nlm.nih.gov/7586300"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.92.11.3172","doi":"https://doi.org/10.1161/01.cir.92.11.3172","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.92.11.3172","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064461375","display_name":"Lucie Lacoste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"Lucie Lacoste","raw_affiliation_strings":["From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800290161","https://openalex.org/I4210088912","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109154151","display_name":"Jules Y.T. Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"Jules Y.T. Lam","raw_affiliation_strings":["From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800290161","https://openalex.org/I4210088912","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103270260","display_name":"Joseph Hung","orcid":"https://orcid.org/0000-0002-4468-6097","observed_orcids":["https://orcid.org/0000-0002-4468-6097"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"Joseph Hung","raw_affiliation_strings":["From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800290161","https://openalex.org/I4210088912","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041929767","display_name":"Glaci Letchacovski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"Glaci Letchacovski","raw_affiliation_strings":["From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800290161","https://openalex.org/I4210088912","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079895214","display_name":"B Solymoss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"Charles B. Solymoss","raw_affiliation_strings":["From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800290161","https://openalex.org/I4210088912","https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108081265","display_name":"David D. Waters","orcid":"https://orcid.org/0000-0002-2786-8198","observed_orcids":["https://orcid.org/0000-0002-2786-8198"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210088912","display_name":"Queen Elizabeth II Medical Centre","ror":"https://ror.org/0071a2k97","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210088912"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["AU","CA"],"is_corresponding":false,"raw_author_name":"David Waters","raw_affiliation_strings":["From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Thrombosis and Atherosclerosis, Department of Medicine, Montreal Heart Institute and University of Montreal, Canada (L.L., J.Y.T.L., G.L., C.B.S., D.W.) and the University of Western Australia, Queen Elizabeth II Medical Center, Nedlands, Perth, Australia (J.H.)","institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800290161","https://openalex.org/I4210088912","https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.8182,"has_fulltext":false,"cited_by_count":442,"citation_normalized_percentile":{"value":0.99714827,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"92","issue":"11","first_page":"3172","last_page":"3177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.051899999380111694,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coronary-disease","display_name":"coronary disease","score":0.6620000004768372},{"id":"https://openalex.org/keywords/platelet-thrombus-formation","display_name":"platelet thrombus formation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cholesterol-lowering","display_name":"cholesterol lowering","score":0.5630000233650208},{"id":"https://openalex.org/keywords/shear-rate","display_name":"shear rate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.6499999761581421},{"id":"https://openalex.org/keywords/plaque-rupture","display_name":"plaque rupture","score":0.6769999861717224},{"id":"https://openalex.org/keywords/acute-coronary-events","display_name":"acute coronary events","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8860188722610474},{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.823492169380188},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.7392340302467346},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7297863364219666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7199485301971436},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6396253108978271},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.5911266207695007},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.524621844291687},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4734986424446106},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.44699326157569885},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4201650619506836},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30194246768951416},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.18340572714805603},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017035","descriptor_name":"Pravastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017540","descriptor_name":"Tunica Media","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.92.11.3172","doi":"https://doi.org/10.1161/01.cir.92.11.3172","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.92.11.3172","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:7586300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7586300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/04a2977a-34cb-4be3-975a-49a1f880584e","doi":null,"is_oa":false,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/04a2977a-34cb-4be3-975a-49a1f880584e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lacoste, L, Lam, J Y T, Hung, J, Letchacovski, G, Solymoss, C B & Waters, D 1995, 'Hyperlipidemia and coronary disease: correction of the increased thrombogenic potential with cholesterol reduction', Circulation, vol. 92, pp. 3172-3177.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W120208674","https://openalex.org/W1512144932","https://openalex.org/W1534126065","https://openalex.org/W1759837874","https://openalex.org/W1848464647","https://openalex.org/W1961781761","https://openalex.org/W1971261277","https://openalex.org/W1975762374","https://openalex.org/W1980300196","https://openalex.org/W2001387351","https://openalex.org/W2004145281","https://openalex.org/W2005786831","https://openalex.org/W2007375934","https://openalex.org/W2012952446","https://openalex.org/W2015546021","https://openalex.org/W2029833995","https://openalex.org/W2053235682","https://openalex.org/W2063709747","https://openalex.org/W2074369923","https://openalex.org/W2079184391","https://openalex.org/W2087542464","https://openalex.org/W2089406251","https://openalex.org/W2089900480","https://openalex.org/W2096190290","https://openalex.org/W2108668893","https://openalex.org/W2115572248","https://openalex.org/W2120860913","https://openalex.org/W2132931461","https://openalex.org/W2132942256","https://openalex.org/W2145799136","https://openalex.org/W2318504971","https://openalex.org/W2319045997","https://openalex.org/W2323738871","https://openalex.org/W2324712847","https://openalex.org/W2331959986","https://openalex.org/W2335979330","https://openalex.org/W2341665659","https://openalex.org/W2413788987","https://openalex.org/W2477685175","https://openalex.org/W3112270648","https://openalex.org/W3194355700","https://openalex.org/W4234181085","https://openalex.org/W4244383122","https://openalex.org/W4244516790","https://openalex.org/W4245512005","https://openalex.org/W4248021162","https://openalex.org/W4249825849","https://openalex.org/W4252241269","https://openalex.org/W4253039236","https://openalex.org/W4285719527","https://openalex.org/W4296883165","https://openalex.org/W4296976561"],"related_works":["https://openalex.org/W1996256445","https://openalex.org/W2056035915","https://openalex.org/W2013653206","https://openalex.org/W2041390357","https://openalex.org/W2562076173","https://openalex.org/W2622597184","https://openalex.org/W2030327198","https://openalex.org/W2578578656","https://openalex.org/W7135456163","https://openalex.org/W2327172638"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypercholesterolemia":[1],"is":[2,12,248],"a":[3,17,38,86,121],"risk":[4,293],"factor":[5],"for":[6,117,263],"coronary":[7,48,63,296],"disease,":[8],"and":[9,43,52,70,84,96,156,163,177,204,225,234,272,279],"platelet":[10,29,141,253],"reactivity":[11],"increased":[13],"with":[14,61,171,250,285],"hypercholesterolemia,":[15],"suggesting":[16],"prethrombotic":[18],"risk.":[19,304],"The":[20],"aim":[21],"of":[22,88,91,124,294],"this":[23],"study":[24],"was":[25,104,146],"to":[26,111,199,211,230],"measure":[27],"mural":[28],"thrombus":[30,68,142,221,254,267],"formation":[31,69,103,143,222,255,268],"on":[32,256],"an":[33,134,251,257],"injured":[34,258],"arterial":[35],"wall":[36],"in":[37,46,75,97,133,148,298],"model":[39],"simulating":[40],"vessel":[41],"stenosis":[42],"plaque":[44],"rupture":[45],"hypercholesterolemic":[47,77,150,189],"disease":[49,64],"patients":[50,60,78,151],"before":[51,83],"after":[53,85],"cholesterol":[54,194,206,281],"reduction.":[55],"METHODS":[56],"AND":[57],"RESULTS:":[58],"Thirty-two":[59],"stable":[62],"were":[65,73,283],"studied.":[66],"Platelet":[67,220,266],"serum":[71],"lipids":[72],"measured":[74],"16":[76,98],"(cholesterol":[79],">":[80],"5.2":[81],"mmol/L)":[82],"mean":[87],"2.5":[89],"months":[90],"pravastatin":[92,191],"therapy":[93],"(40":[94],"mg/d)":[95],"normocholesterolemic":[99,172],"control":[100],"patients.":[101],"Thrombus":[102],"assessed":[105],"by":[106,300],"exposing":[107],"porcine":[108],"aortic":[109],"media":[110],"the":[112,149,154,188,261,292,302],"patient's":[113],"flowing":[114],"venous":[115],"blood":[116],"3":[118],"minutes":[119],"at":[120,129,144,152,223,269],"shear":[122,158,227,274],"rate":[123],"754":[125],"or":[126],"2546":[127],"s-1":[128],"37":[130],"degrees":[131],"C":[132],"ex":[135],"vivo":[136],"superfusion":[137],"chamber.":[138],"Quantitative":[139],"morphometric":[140],"baseline":[145],"higher":[147],"both":[153,270],"high":[155,224,271],"low":[157,226,273],"rates:":[159],"4.8":[160],"+/-":[161,165,175,179,197,201,209,213,232,236],"1.0":[162],"3.3":[164],"0.7":[166],"micron":[167,181,238],"2/mm,":[168,239],"respectively,":[169],"compared":[170],"patients:":[173],"2.1":[174],"0.5":[176],"1.6":[178],"0.4":[180],"2/mm":[182],"(both":[183,216,241],"P":[184,217,242],"<":[185,218,243],".05).":[186,219,244],"In":[187],"patients,":[190],"decreased":[192,229,276],"total":[193,278],"from":[195,207],"6.5":[196],"0.2":[198,202,210],"4.5":[200,208],"mmol/L":[203,215],"LDL":[205,280],"2.8":[212],"0.1":[214],"rates":[228,275],"2.0":[231],"0.3":[233,237],"1.3":[235],"respectively":[240],"CONCLUSIONS:":[245],"Thus,":[246],"hypercholesterolemia":[247],"associated":[249],"enhanced":[252],"artery,":[259],"increasing":[260],"propensity":[262],"acute":[264,295],"thrombosis.":[265],"as":[277],"levels":[282],"reduced":[284],"pravastatin.":[286],"Cholesterol":[287],"lowering":[288],"may":[289],"therefore":[290],"reduce":[291],"events":[297],"part":[299],"reducing":[301],"thrombogenic":[303]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
