{"id":"https://openalex.org/W1968126783","doi":"https://doi.org/10.1016/0304-3959(95)00072-0","title":"Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N -methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics","display_name":"Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N -methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W1968126783","doi":"https://doi.org/10.1016/0304-3959(95)00072-0","mag":"1968126783","pmid":"https://pubmed.ncbi.nlm.nih.gov/8867247"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3959(95)00072-0","doi":"https://doi.org/10.1016/0304-3959(95)00072-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3959(95)00072-0","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014541625","display_name":"I. Nagy","orcid":"https://orcid.org/0000-0003-3475-6108","observed_orcids":["https://orcid.org/0000-0003-3475-6108"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Istvan Nagy","raw_affiliation_strings":["Department of Anatomy and Developmental Biology, University College London, Gower Street, London WCIE 6BT UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, University College London, Gower Street, London WCIE 6BT UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017534594","display_name":"Clifford J. Woolf","orcid":"https://orcid.org/0000-0002-6636-3897","observed_orcids":["https://orcid.org/0000-0002-6636-3897","https://orcid.org/0000-0001-9840-596X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Clifford J. Woolf","raw_affiliation_strings":["Corresponding author","Department of Anatomy and Developmental Biology, University College London, Gower Street, London WCIE 6BT UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author","institution_ids":[]},{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, University College London, Gower Street, London WCIE 6BT UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017534594"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":3.2796,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.91757997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"64","issue":"1","first_page":"59","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7940000295639038},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.7919999957084656},{"id":"https://openalex.org/keywords/neurokinin-receptors","display_name":"neurokinin receptors","score":0.871999979019165},{"id":"https://openalex.org/keywords/ventral-root-potentials","display_name":"ventral root potentials","score":0.8190000057220459},{"id":"https://openalex.org/keywords/compound-action-potential","display_name":"compound action potential","score":0.574999988079071},{"id":"https://openalex.org/keywords/centrally-acting-analgesics","display_name":"centrally acting analgesics","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6078904867172241},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5898473858833313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5230692028999329},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47420647740364075},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43610110878944397},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4218076467514038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2708446979522705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2666304111480713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11182975769042969}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0304-3959(95)00072-0","doi":"https://doi.org/10.1016/0304-3959(95)00072-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3959(95)00072-0","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:8867247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8867247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W18030721","https://openalex.org/W89424506","https://openalex.org/W137432027","https://openalex.org/W1525595367","https://openalex.org/W1628508588","https://openalex.org/W1644399569","https://openalex.org/W1676891587","https://openalex.org/W1782765374","https://openalex.org/W1822822588","https://openalex.org/W1860985526","https://openalex.org/W1966035414","https://openalex.org/W1971434444","https://openalex.org/W1977774988","https://openalex.org/W1980067980","https://openalex.org/W1982276226","https://openalex.org/W1983993630","https://openalex.org/W1985207904","https://openalex.org/W1986029447","https://openalex.org/W1986178615","https://openalex.org/W1986517579","https://openalex.org/W1988059170","https://openalex.org/W1990345891","https://openalex.org/W1990853020","https://openalex.org/W1991095869","https://openalex.org/W1996180460","https://openalex.org/W1996995735","https://openalex.org/W1997681032","https://openalex.org/W1998949476","https://openalex.org/W2002817186","https://openalex.org/W2004401380","https://openalex.org/W2007018158","https://openalex.org/W2011934343","https://openalex.org/W2013161889","https://openalex.org/W2013737321","https://openalex.org/W2016028946","https://openalex.org/W2018601847","https://openalex.org/W2018638145","https://openalex.org/W2018775366","https://openalex.org/W2019406234","https://openalex.org/W2020053962","https://openalex.org/W2024012135","https://openalex.org/W2030386595","https://openalex.org/W2031323742","https://openalex.org/W2032454586","https://openalex.org/W2033587366","https://openalex.org/W2033989627","https://openalex.org/W2034595944","https://openalex.org/W2035331415","https://openalex.org/W2037175122","https://openalex.org/W2037318643","https://openalex.org/W2039890389","https://openalex.org/W2040035927","https://openalex.org/W2041409848","https://openalex.org/W2042691529","https://openalex.org/W2042728046","https://openalex.org/W2048656464","https://openalex.org/W2050052409","https://openalex.org/W2054975255","https://openalex.org/W2056433186","https://openalex.org/W2057288321","https://openalex.org/W2058615066","https://openalex.org/W2065186436","https://openalex.org/W2067320018","https://openalex.org/W2068055837","https://openalex.org/W2070233250","https://openalex.org/W2071715974","https://openalex.org/W2071816031","https://openalex.org/W2076696791","https://openalex.org/W2077069417","https://openalex.org/W2077348695","https://openalex.org/W2083645007","https://openalex.org/W2087027636","https://openalex.org/W2091036097","https://openalex.org/W2093734160","https://openalex.org/W2112733934","https://openalex.org/W2114058218","https://openalex.org/W2116411564","https://openalex.org/W2128265835","https://openalex.org/W2129447376","https://openalex.org/W2148948663","https://openalex.org/W2149372271","https://openalex.org/W2158067363","https://openalex.org/W2158135640","https://openalex.org/W2166828796","https://openalex.org/W2167563378","https://openalex.org/W2239759402","https://openalex.org/W2240012238","https://openalex.org/W2297594911","https://openalex.org/W2405023198","https://openalex.org/W2415353318","https://openalex.org/W2443717624","https://openalex.org/W2500157777","https://openalex.org/W4232614478"],"related_works":["https://openalex.org/W1985207904","https://openalex.org/W2041409848","https://openalex.org/W7033991012","https://openalex.org/W2112733934","https://openalex.org/W2133743917","https://openalex.org/W2050052409","https://openalex.org/W6983510972","https://openalex.org/W2048985663","https://openalex.org/W2117835548","https://openalex.org/W2039676467"],"abstract_inverted_index":{"The":[0,55,157,229],"action":[1,214,283],"of":[2,31,58,89,134,154,159,183,198,240,243,271,278,310,325],"lignocaine":[3,207,272,279],"on":[4,146,211,225,273,284,338],"nociceptive":[5,285],"transmission":[6,286],"in":[7,14,50,139,193,287,303],"the":[8,51,62,76,91,109,129,135,147,155,160,177,194,212,220,226,244,268,274,288,304],"spinal":[9,26,289],"cord":[10,27,290],"has":[11],"been":[12],"studied":[13],"vitro":[15],"using":[16],"ventral":[17,53],"root":[18,34],"potential":[19,215],"(VRP)":[20],"recordings":[21],"from":[22],"10-12-day-old":[23],"rat":[24],"hemisected":[25],"preparations.":[28],"Single-shock":[29],"stimulation":[30],"a":[32,94,112,140,236,281,308],"dorsal":[33,227],"at":[35],"intensities":[36],"sufficient":[37],"to":[38],"activate":[39],"high-threshold":[40,119],"C-primary":[41],"afferent":[42],"fibres":[43],"elicited":[44,217],"VRPs":[45],"lasting":[46,86,103],"for":[47,87,104],"15-20":[48],"sec":[49],"corresponding":[52],"root.":[54,228],"VRP":[56,138,162],"consisted":[57],"3":[59],"distinct":[60],"parts:":[61],"early,":[63],"slow":[64,92,130],"and":[65,83,108,126,131,168,223,248,261,294,316],"prolonged":[66,110,132],"components,":[67],"as":[68,175,333],"previously":[69],"described":[70],"(Thompson":[71],"et":[72],"al.":[73],"1992),":[74],"where":[75],"early":[77,148],"represents":[78],"A":[79,150],"beta":[80,151],"fibre-evoked":[81,137],"mono-":[82],"polysynaptic":[84],"responses":[85],"tens":[88],"milliseconds,":[90],"is":[93,111,292],"largely":[95],"N-methyl-D-aspartic":[96],"acid":[97],"(NMDA)":[98],"receptor-mediated":[99,114,318],"small-calibre":[100],"afferent-generated":[101],"component,":[102],"about":[105],"1.5":[106],"sec,":[107],"neurokinin":[113],"long-lasting":[115],"component":[116,153],"generated":[117,163],"by":[118,164,180,218],"fibres.":[120],"Lignocaine":[121],"superfusion":[122],"(40-60":[123],"microM)":[124,186,192,260,264],"significantly":[125,173,233],"reversibly":[127],"reduced":[128,174,234],"components":[133],"C":[136],"dose-dependent":[141],"manner":[142],"without":[143],"any":[144],"effect":[145,210],"or":[149,187,196,312],"fibre-mediated":[152],"VRP.":[156,275],"amplitude":[158],"cumulative":[161],"repetitive":[165],"inputs":[166],"(1":[167,253],"10":[169],"Hz)":[170],"was":[171,176,231],"also":[172],"depolarization":[178],"produced":[179],"bath":[181],"application":[182],"NMDA":[184],"(100":[185,256,259,263],"substance":[188],"P":[189],"(SP,":[190],"1":[191],"presence":[195],"absence":[197],"tetrodotoxin":[199],"(TTX)":[200],"(300":[201],"nM).":[202],"At":[203],"this":[204,323],"dose":[205,239],"range":[206],"had":[208],"no":[209],"compound":[213],"(CAP)":[216],"stimulating":[219],"sciatic":[221],"nerve":[222],"recorded":[224],"CAP":[230],"only":[232],"with":[235],"300":[237],"microM":[238],"lignocaine.":[241],"Application":[242],"opiate,":[245],"glycine,":[246],"GABAA":[247],"GABAB":[249],"receptor":[250],"antagonists,":[251],"naloxone":[252],"microM),":[254,257],"strychnine":[255],"bicuculline":[258],"phaclofen":[262],"did":[265],"not":[266],"alter":[267],"depressant":[269],"effects":[270],"Low":[276],"concentrations":[277],"have":[280],"selective":[282],"which":[291],"different":[293],"more":[295],"potent":[296],"than":[297],"its":[298],"local":[299],"anaesthetic":[300],"conduction":[301],"blockade":[302],"periphery.":[305],"This":[306],"includes":[307],"reduction":[309],"direct":[311],"synaptically":[313],"driven":[314],"NMDA-":[315],"NK":[317],"post-synaptic":[319],"depolarizations":[320],"indicating":[321],"that":[322],"class":[324],"sodium":[326,340],"channel":[327],"blockers":[328],"may":[329],"be":[330],"potentially":[331],"useful":[332],"analgesic":[334],"agents,":[335],"possibly":[336],"acting":[337],"TTX-resistant":[339],"ion":[341],"channels.":[342]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
