{"id":"https://openalex.org/W1968119697","doi":"https://doi.org/10.7448/ias.17.4.19778","title":"Treatment outcome in HIV+ patients receiving 3\u2010 or 4\u2010drug regimens during PHI","display_name":"Treatment outcome in HIV+ patients receiving 3\u2010 or 4\u2010drug regimens during PHI","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W1968119697","doi":"https://doi.org/10.7448/ias.17.4.19778","mag":"1968119697","pmid":"https://pubmed.ncbi.nlm.nih.gov/25397522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4225434"},"language":"en","primary_location":{"id":"doi:10.7448/ias.17.4.19778","doi":"https://doi.org/10.7448/ias.17.4.19778","is_oa":true,"landing_page_url":"https://doi.org/10.7448/ias.17.4.19778","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.17.4.19778","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.17.4.19778","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019611164","display_name":"Giulia Maria Bottani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Maria Bottani","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062584952","display_name":"Letizia M Oreni","orcid":"https://orcid.org/0009-0008-5186-6310","observed_orcids":["https://orcid.org/0009-0008-5186-6310"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Letizia Oreni","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048401909","display_name":"Giancarlo Orofino","orcid":"https://orcid.org/0000-0003-3115-9674","observed_orcids":["https://orcid.org/0000-0003-3115-9674"]},"institutions":[{"id":"https://openalex.org/I4210110952","display_name":"Ospedale Amedeo di Savoia","ror":"https://ror.org/01p8da469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110952"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Orofino","raw_affiliation_strings":["Infectious Diseases Unit A, Amedeo di Savoia Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit A, Amedeo di Savoia Hospital, Turin, Italy","institution_ids":["https://openalex.org/I4210110952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030019307","display_name":"Pamela Tau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pamela Tau","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086747667","display_name":"Silvia Di Nardo Stuppino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Di Nardo Stuppino","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068906961","display_name":"Elisa Colella","orcid":"https://orcid.org/0000-0003-4912-148X","observed_orcids":["https://orcid.org/0000-0003-4912-148X"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Colella","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079160330","display_name":"Sinibaldo Carosella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110952","display_name":"Ospedale Amedeo di Savoia","ror":"https://ror.org/01p8da469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110952"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sinibaldo Carosella","raw_affiliation_strings":["Infectious Diseases Unit A, Amedeo di Savoia Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit A, Amedeo di Savoia Hospital, Turin, Italy","institution_ids":["https://openalex.org/I4210110952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071944764","display_name":"Marta Guastavigna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110952","display_name":"Ospedale Amedeo di Savoia","ror":"https://ror.org/01p8da469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110952"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Guastavigna","raw_affiliation_strings":["Infectious Diseases Unit A, Amedeo di Savoia Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit A, Amedeo di Savoia Hospital, Turin, Italy","institution_ids":["https://openalex.org/I4210110952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050919587","display_name":"Valeria Ghisetti","orcid":"https://orcid.org/0000-0002-7808-190X","observed_orcids":["https://orcid.org/0000-0002-7808-190X"]},"institutions":[{"id":"https://openalex.org/I4210110952","display_name":"Ospedale Amedeo di Savoia","ror":"https://ror.org/01p8da469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110952"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Ghisetti","raw_affiliation_strings":["Microbiology and Virology Laboratory, Amedeo di Savoia Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Virology Laboratory, Amedeo di Savoia Hospital, Turin, Italy","institution_ids":["https://openalex.org/I4210110952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075069140","display_name":"Valeria Micheli","orcid":"https://orcid.org/0000-0001-5629-3875","observed_orcids":["https://orcid.org/0000-0001-5629-3875"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Micheli","raw_affiliation_strings":["Clinical Microbiology, Virology and Bioemergency, Luigi Sacco Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Microbiology, Virology and Bioemergency, Luigi Sacco Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010351936","display_name":"Massimo Galli","orcid":"https://orcid.org/0000-0001-8887-6215","observed_orcids":["https://orcid.org/0000-0001-8887-6215"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Galli","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052366087","display_name":"Stefano Rusconi","orcid":"https://orcid.org/0000-0002-0375-9990","observed_orcids":["https://orcid.org/0000-0002-0375-9990"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Rusconi","raw_affiliation_strings":["Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, DIBIC Luigi Sacco, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.396,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53985067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"17","issue":"4S3","first_page":"19778","last_page":"19778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6431000232696533,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6431000232696533,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.04699999839067459,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-hiv-infection","display_name":"acute HIV infection","score":0.7059999704360962},{"id":"https://openalex.org/keywords/recent-hiv-infection","display_name":"recent HIV infection","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/raltegravir","display_name":"raltegravir","score":0.8190000057220459},{"id":"https://openalex.org/keywords/maraviroc","display_name":"maraviroc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.7789999842643738},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/hiv-tropism","display_name":"HIV tropism","score":0.5090000033378601},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.4009999930858612},{"id":"https://openalex.org/keywords/treatment-modification","display_name":"treatment modification","score":0.3919999897480011},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.527999997138977},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9037741422653198},{"id":"https://openalex.org/C2780404665","wikidata":"https://www.wikidata.org/wiki/Q421552","display_name":"Raltegravir","level":5,"score":0.7782805562019348},{"id":"https://openalex.org/C2778899366","wikidata":"https://www.wikidata.org/wiki/Q421369","display_name":"Maraviroc","level":3,"score":0.7664556503295898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6747011542320251},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4507113993167877},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.42406585812568665},{"id":"https://openalex.org/C2777813720","wikidata":"https://www.wikidata.org/wiki/Q1243018","display_name":"Coinfection","level":3,"score":0.4138447046279907},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4086095094680786},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40082359313964844},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.400201678276062},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37255316972732544},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.25261950492858887}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.7448/ias.17.4.19778","doi":"https://doi.org/10.7448/ias.17.4.19778","is_oa":true,"landing_page_url":"https://doi.org/10.7448/ias.17.4.19778","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.17.4.19778","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3198510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4225434","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4225434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4225434","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int AIDS Soc","raw_type":"Text"},{"id":"pmid:25397522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25397522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7448/ias.17.4.19778","doi":"https://doi.org/10.7448/ias.17.4.19778","is_oa":true,"landing_page_url":"https://doi.org/10.7448/ias.17.4.19778","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.17.4.19778","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968119697.pdf","grobid_xml":"https://content.openalex.org/works/W1968119697.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3083816005","https://openalex.org/W2324398986","https://openalex.org/W2117680693","https://openalex.org/W2051794413","https://openalex.org/W4220767969","https://openalex.org/W1998994059","https://openalex.org/W3006776090","https://openalex.org/W2411710478","https://openalex.org/W2025365005","https://openalex.org/W4386812747"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"optimal":[2],"timing":[3],"and":[4,26,76,116,140,225,237,298,327],"modality":[5],"of":[6,12,44,71,74,124,244,304,313,335,346,359,366],"therapeutic":[7],"intervention":[8],"during":[9,33,162],"early":[10],"phases":[11],"HIV":[13,37,62],"infection":[14,58,63,168,198,246,337],"is":[15],"still":[16,271],"debated;":[17],"in":[18,29,149,159,203,292,310,342,349],"our":[19],"prospective":[20],"observational":[21],"study":[22],"we":[23],"evaluated":[24],"immunological":[25,293],"virological":[27,204,295,331],"outcome":[28,362],"HIV+":[30],"patients":[31,47,160,322],"treated":[32,161,280],"acute":[34,49,163,195,245,350],"or":[35,55,90,101,196,283,302],"recent":[36,56,166,197,353],"infection.":[38,354],"MATERIALS":[39],"AND":[40],"METHODS:":[41],"A":[42],"total":[43],"25":[45,314],"na\u00efve":[46],"with":[48,85,89,95,194,230,241,265,281],"(detectable":[50],"HIV-RNA,":[51,113],"immature":[52],"Western":[53],"Blot)":[54],"(documented":[57],"within":[59],"six":[60,108,218],"months)":[61],"were":[64,119],"recruited":[65],"at":[66,121,209,217,233,256,268],"the":[67,72,122,125,242,262,344,364,371],"Infectious":[68],"Diseases":[69],"Units":[70],"University":[73],"Milan":[75],"Turin":[77],"from":[78,152],"2009":[79],"to":[80,143,154,189,339,370],"2014.":[81],"Patients":[82,128,193,279],"received":[83],"treatment":[84,126],"two":[86,321],"NRTIs+one":[87],"NNRTI/bPI,":[88],"without":[91,273],"an":[92,96,227],"induction":[93],"phase":[94],"additional":[97],"fourth":[98,368],"drug":[99,369],"(raltegravir":[100],"maraviroc)":[102],"until":[103],"HIV-RNA":[104,141],"undetectability":[105],"maintained":[106,183],"for":[107,112,134,306],"months.":[109,145],"Blood":[110],"samples":[111],"lymphocyte":[114],"subsets":[115],"tropism":[117],"assessment":[118],"obtained":[120],"beginning":[123],"(BL).":[127],"underwent":[129,323],"subsequent":[130],"six-monthly":[131],"follow":[132],"up":[133,142],"clinical":[135],"outcome,":[136],"CD4":[137,150,214,231,266,347],"cell":[138],"count":[139],"18":[144,185,328],"RESULTS:":[146],"Median":[147],"increase":[148],"cells":[151,215,348],"0":[153],"12":[155,210,257,326],"months":[156,219,258,329],"was":[157,182,270,356],"greater":[158],"(n=18)":[164],"versus":[165,172,207],"(n=7)":[167],"[284/\u00b5L,":[169],"IQR":[170,174],"(227-456)":[171],"176/\u00b5L,":[173],"(70-235);":[175],"Mann-Whitney":[176],"test,":[177],"p=0.046].":[178],"This":[179,250],"higher":[180],"value":[181],"through":[184,363],"months,":[186],"although":[187],"failing":[188],"reach":[190],"statistical":[191,254,275],"significance.":[192],"did":[199,286],"not":[200,287],"significantly":[201],"differ":[202],"success":[205],"(83.3%":[206],"85.7%":[208],"months).":[211],"We":[212],"considered":[213],"gains":[216],"(multivariate":[220],"analysis,":[221],"ANCOVA;":[222],"Figure":[223],"1)":[224],"detected":[226],"inverse":[228,263],"correlation":[229,240,252,264],"levels":[232,267],"BL":[234,269],"(r=-0.517;":[235],"p=0.008)":[236],"a":[238,274,360,367],"direct":[239],"status":[243],"(r=0.234,":[247],"p":[248],"NS).":[249],"last":[251],"reached":[253],"significance":[255,276],"(r=0.418,":[259],"p=0.035),":[260],"whereas":[261],"present":[272],"(r=-0.350;":[277],"p=0.072).":[278],"three":[282],"four":[284,319],"drugs":[285],"show":[288],"any":[289],"significant":[290],"difference":[291],"nor":[294],"response":[296],"(Mann-Whitney":[297],"\u03c7(2)":[299],"test).":[300],"Modification":[301],"interruption":[303],"therapy":[305],"tolerability":[307],"took":[308],"place":[309],"4":[311],"out":[312],"patients,":[315],"all":[316],"while":[317],"receiving":[318],"drugs;":[320],"STI":[324],"between":[325],"following":[330],"success.":[332],"CONCLUSIONS:":[333],"Treatment":[334],"primary":[336],"appeared":[338],"be":[340],"effective":[341],"preserving":[343],"pool":[345],"more":[351],"than":[352],"There":[355],"no":[357],"evidence":[358],"different":[361],"addition":[365],"standard":[372],"treatment.":[373]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}