{"id":"https://openalex.org/W1968107961","doi":"https://doi.org/10.1074/jbc.m111640200","title":"Identification of Target Tissue Glycosphingolipid Receptors for Uropathogenic, F1C-fimbriated Escherichia coli and Its Role in Mucosal Inflammation","display_name":"Identification of Target Tissue Glycosphingolipid Receptors for Uropathogenic, F1C-fimbriated Escherichia coli and Its Role in Mucosal Inflammation","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W1968107961","doi":"https://doi.org/10.1074/jbc.m111640200","mag":"1968107961","pmid":"https://pubmed.ncbi.nlm.nih.gov/11877427"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111640200","doi":"https://doi.org/10.1074/jbc.m111640200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111640200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111640200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047963662","display_name":"Fredrik B\u00e4ckhed","orcid":"https://orcid.org/0000-0002-4871-8818","observed_orcids":["https://orcid.org/0000-0002-4871-8818"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fredrik B\u00e4ckhed","raw_affiliation_strings":["Microbiology and Tumorbiology Center, Karolinska Institute, SE 171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Tumorbiology Center, Karolinska Institute, SE 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041406098","display_name":"Bj\u00f6rn Als\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Als\u00e9n","raw_affiliation_strings":["Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Niamh Roche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Niamh Roche","raw_affiliation_strings":["Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011595394","display_name":"Jonas \u00c5ngstr\u00f6m","orcid":"https://orcid.org/0000-0002-4752-5491","observed_orcids":["https://orcid.org/0000-0002-4752-5491"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas \u00c5ngstr\u00f6m","raw_affiliation_strings":["Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109977602","display_name":"Anne von Euler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anne von Euler","raw_affiliation_strings":["Microbiology and Tumorbiology Center, Karolinska Institute, SE 171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Tumorbiology Center, Karolinska Institute, SE 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026854577","display_name":"Michael E. Breimer","orcid":"https://orcid.org/0000-0003-4279-0736","observed_orcids":["https://orcid.org/0000-0003-4279-0736"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Michael E. Breimer","raw_affiliation_strings":["Department of Surgery, Sahlgrenska University Hospital, SE 413 45 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Sahlgrenska University Hospital, SE 413 45 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051296067","display_name":"Benita Westerlund\u2010Wikstr\u00f6m","orcid":"https://orcid.org/0000-0002-5307-3858","observed_orcids":["https://orcid.org/0000-0002-5307-3858"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Benita Westerlund-Wikstr\u00f6m","raw_affiliation_strings":["Division of General Microbiology, Department of Biosciences, P. O. Box 56, University of Helsinki, Helsinki FIN-00014 Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Microbiology, Department of Biosciences, P. O. Box 56, University of Helsinki, Helsinki FIN-00014 Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010330990","display_name":"Susann Teneberg","orcid":"https://orcid.org/0000-0003-1957-9553","observed_orcids":["https://orcid.org/0000-0003-1957-9553"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Susann Teneberg","raw_affiliation_strings":["Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry, G\u00f6teborg University, P. O. Box 440, SE 405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056756922","display_name":"Agneta Richter\u2010Dahlfors","orcid":"https://orcid.org/0000-0002-5479-7591","observed_orcids":["https://orcid.org/0000-0002-5479-7591"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Agneta Richter-Dahlfors","raw_affiliation_strings":["Microbiology and Tumorbiology Center, Karolinska Institute, SE 171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Tumorbiology Center, Karolinska Institute, SE 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010330990"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.6594,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.92511802,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"277","issue":"20","first_page":"18198","last_page":"18205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glycosphingolipid-receptors","display_name":"glycosphingolipid receptors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/galactosylceramide","display_name":"galactosylceramide","score":0.9120000004768372},{"id":"https://openalex.org/keywords/globotriaosylceramide","display_name":"globotriaosylceramide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phytosphingosine","display_name":"phytosphingosine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.6859999895095825},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.7609999775886536},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.3919999897480011},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9259999990463257},{"id":"https://openalex.org/keywords/urothelium","display_name":"urothelium","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2777687718","wikidata":"https://www.wikidata.org/wiki/Q410539","display_name":"Globotriaosylceramide","level":4,"score":0.8999379277229309},{"id":"https://openalex.org/C39103817","wikidata":"https://www.wikidata.org/wiki/Q1810775","display_name":"Fimbria","level":4,"score":0.8532019257545471},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7317777872085571},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6339689493179321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.619735836982727},{"id":"https://openalex.org/C2776931407","wikidata":"https://www.wikidata.org/wiki/Q418892","display_name":"Glycosphingolipid","level":2,"score":0.5353538990020752},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49018770456314087},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.48615023493766785},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4496229588985443},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.4332762360572815},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.422067254781723},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4143468141555786},{"id":"https://openalex.org/C174832134","wikidata":"https://www.wikidata.org/wiki/Q934786","display_name":"Pilus","level":4,"score":0.4116849899291992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.303851842880249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09433093667030334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07732608914375305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06631866097450256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06449544429779053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2777404818","wikidata":"https://www.wikidata.org/wiki/Q615645","display_name":"Fabry disease","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005699","descriptor_name":"Galactosylceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006028","descriptor_name":"Glycosphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014281","descriptor_name":"Trihexosylceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m111640200","doi":"https://doi.org/10.1074/jbc.m111640200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111640200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11877427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11877427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111640200","doi":"https://doi.org/10.1074/jbc.m111640200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111640200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W980771929","https://openalex.org/W1022571150","https://openalex.org/W1480735239","https://openalex.org/W1488620239","https://openalex.org/W1501761217","https://openalex.org/W1504852203","https://openalex.org/W1815977795","https://openalex.org/W1831252711","https://openalex.org/W1842089729","https://openalex.org/W1854822574","https://openalex.org/W1871555078","https://openalex.org/W1912780462","https://openalex.org/W1965407722","https://openalex.org/W1970674113","https://openalex.org/W1973139883","https://openalex.org/W1984755921","https://openalex.org/W1990731735","https://openalex.org/W1991155185","https://openalex.org/W1995025776","https://openalex.org/W1999823179","https://openalex.org/W2003974324","https://openalex.org/W2032304130","https://openalex.org/W2036083275","https://openalex.org/W2069164006","https://openalex.org/W2086281512","https://openalex.org/W2094503183","https://openalex.org/W2094775957","https://openalex.org/W2098436673","https://openalex.org/W2103224467","https://openalex.org/W2109359144","https://openalex.org/W2116022976","https://openalex.org/W2125773426","https://openalex.org/W2134353518","https://openalex.org/W2154423973","https://openalex.org/W2161195329","https://openalex.org/W2162749433","https://openalex.org/W2163200420","https://openalex.org/W2318214875","https://openalex.org/W2335329422","https://openalex.org/W4237880270"],"related_works":["https://openalex.org/W2117980797","https://openalex.org/W2154423973","https://openalex.org/W2081240544","https://openalex.org/W1995025776","https://openalex.org/W4244096544","https://openalex.org/W1815977795","https://openalex.org/W2184288446","https://openalex.org/W2055721575","https://openalex.org/W2414853373","https://openalex.org/W2122186807"],"abstract_inverted_index":{"Bacterial":[0],"adherence":[1],"to":[2,27,50,164],"mucosal":[3,178],"cells":[4,166],"is":[5,129],"a":[6,153,172],"key":[7],"virulence":[8],"trait":[9],"of":[10,20,33,66,160],"pathogenic":[11],"bacteria.":[12],"The":[13,59],"type":[14,46,65],"1":[15,47],"fimbriae":[16,48,61],"and":[17,57,99,107,111,116,142],"the":[18,31,43,51,126,132,139,150],"P-fimbriae":[19,38],"Escherichia":[21,162],"coli":[22,163],"have":[23],"both":[24,113],"been":[25],"described":[26],"be":[28],"important":[29],"for":[30,174],"establishment":[32],"urinary":[34,101],"tract":[35],"infections.":[36,182],"While":[37],"recognize":[39],"kidney":[40,143],"glycosphingolipids":[41,94,123],"carrying":[42],"Galalpha4Gal":[44],"determinant,":[45],"bind":[49],"urothelial":[52],"mannosylated":[53],"glycoproteins":[54],"uroplakin":[55],"Ia":[56],"Ib.":[58],"F1C":[60],"are":[62],"one":[63],"additional":[64],"fimbria":[67],"correlated":[68],"with":[69,91,114,121],"uropathogenicity.":[70],"Although":[71],"it":[72],"was":[73,136,146],"identified":[74],"20":[75],"years":[76],"ago":[77],"its":[78],"receptor":[79,127],"has":[80],"remained":[81],"unidentified.":[82],"Here":[83],"we":[84,156],"report":[85],"that":[86,125,158],"F1C-fimbriated":[87,161],"bacteria":[88],"selectively":[89],"interact":[90],"two":[92],"minor":[93],"isolated":[95,106],"from":[96],"rat,":[97],"canine,":[98],"human":[100],"tract.":[102],"Binding-active":[103],"compounds":[104],"were":[105],"characterized":[108],"as":[109],"galactosylceramide,":[110],"globotriaosylceramide,":[112],"phytosphingosine":[115],"hydroxy":[117],"fatty":[118],"acids.":[119],"Comparison":[120],"reference":[122],"revealed":[124],"specificity":[128],"dependent":[130],"on":[131],"ceramide":[133],"composition.":[134],"Galactosylceramide":[135],"present":[137,147],"in":[138,149,177],"bladder,":[140],"urethers,":[141],"while":[144],"globotriaosylceramide":[145],"only":[148],"kidney.":[151],"Using":[152],"functional":[154],"assay,":[155],"demonstrate":[157],"binding":[159],"renal":[165],"induces":[167],"interleukin-8":[168],"production,":[169],"thus":[170],"suggesting":[171],"role":[173],"F1C-mediated":[175],"attachment":[176],"defense":[179],"against":[180],"bacterial":[181]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}