{"id":"https://openalex.org/W1968104630","doi":"https://doi.org/10.1007/bf00769638","title":"Molecular defects of NADH-ubiquinone oxidoreductase (Complex I) in mitochondrial diseases","display_name":"Molecular defects of NADH-ubiquinone oxidoreductase (Complex I) in mitochondrial diseases","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W1968104630","doi":"https://doi.org/10.1007/bf00769638","mag":"1968104630","pmid":"https://pubmed.ncbi.nlm.nih.gov/3136150"},"language":"en","primary_location":{"id":"doi:10.1007/bf00769638","doi":"https://doi.org/10.1007/bf00769638","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00769638","pdf_url":null,"source":{"id":"https://openalex.org/S105581463","display_name":"Journal of Bioenergetics and Biomembranes","issn_l":"0145-479X","issn":["0145-479X","1573-6881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioenergetics and Biomembranes","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049268198","display_name":"JOHN A. MORGAN-HUGHES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John A. Morgan-Hughes","raw_affiliation_strings":["Institute of Neurology, Queen Square, London","Institute of Neurology, Queen Square, WC1N 3BG, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurology, Queen Square, London","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]},{"raw_affiliation_string":"Institute of Neurology, Queen Square, WC1N 3BG, London","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059770430","display_name":"Anthony H.V. Schapira","orcid":"https://orcid.org/0000-0002-3018-3966","observed_orcids":["https://orcid.org/0000-0002-3018-3966"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony H. V. Schapira","raw_affiliation_strings":["Institute of Neurology, London","Institute of Neurology, Queen Square, WC1N 3BG, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurology, London","institution_ids":["https://openalex.org/I4405260083"]},{"raw_affiliation_string":"Institute of Neurology, Queen Square, WC1N 3BG, London","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062570162","display_name":"J Allen D Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Mark Cooper","raw_affiliation_strings":["Department of Biochemistry, St Bartholomew's Hospital Medical School, London","Institute of Neurology, London","Institute of Neurology, Queen Square, WC1N 3BG, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, St Bartholomew's Hospital Medical School, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]},{"raw_affiliation_string":"Institute of Neurology, London","institution_ids":["https://openalex.org/I4405260083"]},{"raw_affiliation_string":"Institute of Neurology, Queen Square, WC1N 3BG, London","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103643097","display_name":"J. B. Clark","orcid":"https://orcid.org/0000-0002-1162-1238","observed_orcids":["https://orcid.org/0000-0002-1162-1238"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John B. Clark","raw_affiliation_strings":["Department of Biochemistry, St Bartholomew's Hospital Medical School, London","Department of Biochemistry, St Bartholomew's Hospital Medical School, Charterhouse Square, EC1M 6BQ, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, St Bartholomew's Hospital Medical School, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]},{"raw_affiliation_string":"Department of Biochemistry, St Bartholomew's Hospital Medical School, Charterhouse Square, EC1M 6BQ, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.2363,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.80650407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"3","first_page":"365","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complex-i","display_name":"complex I","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain","display_name":"mitochondrial respiratory chain","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/molecular-defects","display_name":"molecular defects","score":0.8050000071525574},{"id":"https://openalex.org/keywords/genetic-abnormalities","display_name":"genetic abnormalities","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nuclear-genes","display_name":"nuclear genes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.7099999785423279},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2909692557","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron Transport Complex I","level":4,"score":0.5811870098114014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5587777495384216},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.5324251055717468},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5254525542259216},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.5219923257827759},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5169519782066345},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.49334946274757385},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.4929234981536865},{"id":"https://openalex.org/C20750100","wikidata":"https://www.wikidata.org/wiki/Q7068120","display_name":"Nuclear gene","level":4,"score":0.48627936840057373},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46716225147247314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44288238883018494},{"id":"https://openalex.org/C113253001","wikidata":"https://www.wikidata.org/wiki/Q864640","display_name":"Bioorganic chemistry","level":3,"score":0.4401651620864868},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40620991587638855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27891805768013},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14902442693710327}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/bf00769638","doi":"https://doi.org/10.1007/bf00769638","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00769638","pdf_url":null,"source":{"id":"https://openalex.org/S105581463","display_name":"Journal of Bioenergetics and Biomembranes","issn_l":"0145-479X","issn":["0145-479X","1573-6881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bioenergetics and Biomembranes","raw_type":"journal-article"},{"id":"pmid:3136150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3136150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bioenergetics and biomembranes","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:192468","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/192468/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J BIOENERG BIOMEMBR , 20 (3) 365 - 382. (1988)","raw_type":"Article"},{"id":"mag:294076376","doi":null,"is_oa":false,"landing_page_url":"http://rd.springer.com/content/pdf/10.1007%2FBF00769638.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310746","display_name":"Judith Jane Mason and Harold Stannett Williams Memorial Foundation","ror":null},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320072","display_name":"Brain Research Trust","ror":"https://ror.org/04q4ck618"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W10205671","https://openalex.org/W96743316","https://openalex.org/W120730866","https://openalex.org/W215319721","https://openalex.org/W315113715","https://openalex.org/W598275417","https://openalex.org/W1494707477","https://openalex.org/W1526469700","https://openalex.org/W1535540896","https://openalex.org/W1544004198","https://openalex.org/W1564317431","https://openalex.org/W1594372611","https://openalex.org/W1595107891","https://openalex.org/W1644090288","https://openalex.org/W1965129012","https://openalex.org/W1966538302","https://openalex.org/W1971386446","https://openalex.org/W1975112317","https://openalex.org/W1975619335","https://openalex.org/W1976901577","https://openalex.org/W1989912644","https://openalex.org/W1991335729","https://openalex.org/W1997517505","https://openalex.org/W2002420413","https://openalex.org/W2003490031","https://openalex.org/W2010298389","https://openalex.org/W2016387484","https://openalex.org/W2018289835","https://openalex.org/W2034704231","https://openalex.org/W2036625365","https://openalex.org/W2039559630","https://openalex.org/W2041850796","https://openalex.org/W2044418764","https://openalex.org/W2044806355","https://openalex.org/W2046042539","https://openalex.org/W2050616306","https://openalex.org/W2052988074","https://openalex.org/W2055841259","https://openalex.org/W2074850155","https://openalex.org/W2077414996","https://openalex.org/W2079169894","https://openalex.org/W2082918093","https://openalex.org/W2088101905","https://openalex.org/W2088565761","https://openalex.org/W2089708482","https://openalex.org/W2091390708","https://openalex.org/W2091467829","https://openalex.org/W2095488982","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2109291482","https://openalex.org/W2142168650","https://openalex.org/W2145956843","https://openalex.org/W2152214802","https://openalex.org/W2153960414","https://openalex.org/W2155399348","https://openalex.org/W2165268250","https://openalex.org/W2180902922","https://openalex.org/W2213917511","https://openalex.org/W2227446991","https://openalex.org/W2270012789","https://openalex.org/W2270071474","https://openalex.org/W2278725473","https://openalex.org/W2309992143","https://openalex.org/W2338435164","https://openalex.org/W2343763188","https://openalex.org/W3134584985","https://openalex.org/W4206515941","https://openalex.org/W4234124119","https://openalex.org/W4252096579","https://openalex.org/W4252645571"],"related_works":["https://openalex.org/W294076376","https://openalex.org/W2768313833","https://openalex.org/W2025333861","https://openalex.org/W2094213440","https://openalex.org/W2890795516","https://openalex.org/W7135762228","https://openalex.org/W2526826094","https://openalex.org/W2134807790","https://openalex.org/W2171717651","https://openalex.org/W2032790885"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}