{"id":"https://openalex.org/W1968104045","doi":"https://doi.org/10.1210/endo-101-1-93","title":"Characteristics of Pituitary Colloid Proteins and Their Correlation with Blood Pressure in the Rat1","display_name":"Characteristics of Pituitary Colloid Proteins and Their Correlation with Blood Pressure in the Rat1","publication_year":1977,"publication_date":"1977-07-01","ids":{"openalex":"https://openalex.org/W1968104045","doi":"https://doi.org/10.1210/endo-101-1-93","mag":"1968104045","pmid":"https://pubmed.ncbi.nlm.nih.gov/862565"},"language":"en","primary_location":{"id":"doi:10.1210/endo-101-1-93","doi":"https://doi.org/10.1210/endo-101-1-93","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-101-1-93","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023480786","display_name":"John P. Rapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN P. RAPP","raw_affiliation_strings":["Departments of Medicine and Pathology, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006032278","display_name":"LLOYD BERGON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LLOYD BERGON","raw_affiliation_strings":["Departments of Medicine and Pathology, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12057038"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.3805,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80553724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"101","issue":"1","first_page":"93","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.16910000145435333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salt-resistant-rats","display_name":"salt-resistant rats","score":0.777999997138977},{"id":"https://openalex.org/keywords/dahl-salt-resistant-rats","display_name":"Dahl salt-resistant rats","score":0.6819999814033508},{"id":"https://openalex.org/keywords/salt-sensitive-rats","display_name":"salt-sensitive rats","score":0.7889999747276306},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6690000295639038},{"id":"https://openalex.org/keywords/salt-induced-hypertension","display_name":"salt-induced hypertension","score":0.796999990940094},{"id":"https://openalex.org/keywords/sodium-metabolism","display_name":"sodium metabolism","score":0.7599999904632568},{"id":"https://openalex.org/keywords/protein-molecular-weight","display_name":"protein molecular weight","score":0.6330000162124634},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.9179999828338623},{"id":"https://openalex.org/keywords/protein-polymers","display_name":"protein polymers","score":0.6039999723434448},{"id":"https://openalex.org/keywords/sodium-chloride-diet","display_name":"sodium chloride diet","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.7588987350463867},{"id":"https://openalex.org/C50476208","wikidata":"https://www.wikidata.org/wiki/Q898861","display_name":"Isoelectric focusing","level":3,"score":0.7146527171134949},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.630786657333374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6206294894218445},{"id":"https://openalex.org/C59789625","wikidata":"https://www.wikidata.org/wiki/Q181780","display_name":"Colloid","level":2,"score":0.6135357618331909},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6129777431488037},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.6022126078605652},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.5470247864723206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.51726895570755},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.4813455045223236},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.4605691730976105},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4464869499206543},{"id":"https://openalex.org/C40250595","wikidata":"https://www.wikidata.org/wiki/Q185098","display_name":"Electrophoresis","level":2,"score":0.43486320972442627},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.4202394187450409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3890654146671295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3459804654121399},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13299578428268433},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12080690264701843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09091487526893616},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003102","descriptor_name":"Colloids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007525","descriptor_name":"Isoelectric Focusing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007526","descriptor_name":"Isoelectric Point","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-101-1-93","doi":"https://doi.org/10.1210/endo-101-1-93","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-101-1-93","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:862565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/862565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2252351231","https://openalex.org/W2470336166","https://openalex.org/W1665913148","https://openalex.org/W2315779678","https://openalex.org/W2005956675","https://openalex.org/W2619421912","https://openalex.org/W4255449879","https://openalex.org/W1983792388","https://openalex.org/W2401700346","https://openalex.org/W2344327987"],"abstract_inverted_index":{"Salt":[0],"resistant":[1],"rats":[2,25,38],"(R-strain":[3],"of":[4,9,22,27,32,50,60,102,107,125,137,166,181],"Dahl)":[5],"accumulate":[6],"large":[7],"amounts":[8],"colloid":[10,16,35],"in":[11,20,48,140,157,169],"the":[12,164,170],"pituitary":[13,33,135,171],"cleft.":[14],"Such":[15],"is":[17],"largely":[18],"absent":[19],"pituitaries":[21],"salt":[23],"susceptible":[24],"(S-strain":[26],"Dahl).":[28],"Polyacrylamide":[29],"gel":[30],"electrophoresis":[31],"cleft":[34,172],"from":[36],"R":[37,142,167],"shows":[39],"4":[40],"proteins,":[41],"designated":[42],"R1,":[43,89],"R2,":[44,108],"R3":[45,109],"and":[46,64,83,91,97,110,121],"R4":[47,111],"order":[49],"decreasing":[51],"electrophoretic":[52],"mobility.":[53],"These":[54],"proteins":[55,168],"have":[56],"apparent":[57,70],"molecular":[58,105],"weights":[59,106],"52,000,":[61],"63,000,":[62],"130,000":[63],"greater":[65],"than":[66],"235,000,":[67],"respectively.":[68,85],"Their":[69],"isoelectric":[71,77],"points":[72],"as":[73],"determined":[74],"by":[75],"preparative":[76],"focusing":[78],"are":[79,99],"4.82,":[80],"5.02,":[81],"5.54":[82],"4.35,":[84],"Ferguson":[86],"plots":[87],"for":[88,129],"R2":[90,98,114],"rat":[92],"albumin":[93],"suggest":[94,112],"that":[95,113,163],"R1":[96,138,147],"size":[100],"isomers":[101],"albumin.":[103],"The":[104],"may":[115],"polymerize":[116],"to":[117,154],"form":[118],"a":[119],"dimer":[120],"tetramer.":[122],"Chronic":[123],"feeding":[124],"8%":[126],"NaCl":[127],"diet":[128],"6":[130],"weeks":[131],"does":[132],"not":[133],"influence":[134],"accumulation":[136,148,165],"protein":[139],"either":[141],"or":[143],"S":[144],"rats.":[145],"Pituitary":[146],"does,":[149],"however,":[150],"segregate":[151],"with":[152,179],"resistance":[153],"salt-induced":[155],"hypertension":[156],"genetic":[158],"experiments.":[159],"This":[160],"strongly":[161],"suggests":[162],"reflects":[173],"some":[174],"genetically":[175],"controlled":[176],"change":[177],"concerned":[178],"control":[180],"sodium":[182],"metabolism.":[183]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}