{"id":"https://openalex.org/W1968073531","doi":"https://doi.org/10.1074/jbc.m010056200","title":"The Tumor-sensitive Calmodulin-like Protein Is a Specific Light Chain of Human Unconventional Myosin X","display_name":"The Tumor-sensitive Calmodulin-like Protein Is a Specific Light Chain of Human Unconventional Myosin X","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W1968073531","doi":"https://doi.org/10.1074/jbc.m010056200","mag":"1968073531","pmid":"https://pubmed.ncbi.nlm.nih.gov/11278607"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m010056200","doi":"https://doi.org/10.1074/jbc.m010056200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m010056200","pdf_url":"http://www.jbc.org/article/S0021925819461036/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819461036/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011470323","display_name":"Michael S. Rogers","orcid":"https://orcid.org/0000-0002-5250-8434","observed_orcids":["https://orcid.org/0000-0002-5250-8434"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Rogers","raw_affiliation_strings":["Tumor Biology Program, Department of Biochemistry and Molecular Biology, Mayo Graduate School and Mayo Clinic Cancer Center, Mayo Clinic/Foundation, Rochester, Minnesota 55905, USA","From the Tumor Biology Program, Department of Biochemistry and Molecular Biology, Mayo Graduate School and Mayo Clinic Cancer Center, Mayo Clinic/Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Biology Program, Department of Biochemistry and Molecular Biology, Mayo Graduate School and Mayo Clinic Cancer Center, Mayo Clinic/Foundation, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]},{"raw_affiliation_string":"From the Tumor Biology Program, Department of Biochemistry and Molecular Biology, Mayo Graduate School and Mayo Clinic Cancer Center, Mayo Clinic/Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090092674","display_name":"Emanuel E. Strehler","orcid":"https://orcid.org/0000-0001-5998-7055","observed_orcids":["https://orcid.org/0000-0001-5998-7055"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emanuel E. Strehler","raw_affiliation_strings":["From the Tumor Biology Program, Department of Biochemistry and Molecular Biology, Mayo Graduate School and Mayo Clinic Cancer Center, Mayo Clinic/Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Tumor Biology Program, Department of Biochemistry and Molecular Biology, Mayo Graduate School and Mayo Clinic Cancer Center, Mayo Clinic/Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090092674"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5074,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.80560521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"276","issue":"15","first_page":"12182","last_page":"12189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.10490000247955322,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin-like-proteins","display_name":"calmodulin-like proteins","score":0.9919999837875366},{"id":"https://openalex.org/keywords/myosin-light-chain","display_name":"myosin light chain","score":0.7950000166893005},{"id":"https://openalex.org/keywords/iq-motif","display_name":"IQ motif","score":0.9210000038146973},{"id":"https://openalex.org/keywords/calcium-dependent-protein-protein-interaction","display_name":"calcium-dependent protein-protein interaction","score":0.8579999804496765},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.9141082763671875},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.8004692792892456},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.76670241355896},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.58016437292099},{"id":"https://openalex.org/C2775847163","wikidata":"https://www.wikidata.org/wiki/Q5023049","display_name":"Calmodulin-binding proteins","level":4,"score":0.5413084626197815},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.5225574374198914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5021452903747559},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4225141704082489},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33975616097450256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28565657138824463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12737572193145752},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m010056200","doi":"https://doi.org/10.1074/jbc.m010056200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m010056200","pdf_url":"http://www.jbc.org/article/S0021925819461036/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11278607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11278607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m010056200","doi":"https://doi.org/10.1074/jbc.m010056200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m010056200","pdf_url":"http://www.jbc.org/article/S0021925819461036/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8054546704","display_name":"BIOLOGY OF CANCER: A PREDOCTORAL TRAINING PROGRAM","funder_award_id":"T32CA075926","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320306937","display_name":"Fraternal Order of Eagles","ror":"https://ror.org/01er75989"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332447","display_name":"U.S. Army","ror":"https://ror.org/00afsp483"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968073531.pdf","grobid_xml":"https://content.openalex.org/works/W1968073531.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W28102849","https://openalex.org/W126126575","https://openalex.org/W159935233","https://openalex.org/W276882634","https://openalex.org/W376204228","https://openalex.org/W1519419895","https://openalex.org/W1977186059","https://openalex.org/W1981446978","https://openalex.org/W1982084887","https://openalex.org/W1985764146","https://openalex.org/W1986923060","https://openalex.org/W1990955490","https://openalex.org/W1991797169","https://openalex.org/W1999525967","https://openalex.org/W2004485255","https://openalex.org/W2004580933","https://openalex.org/W2012704789","https://openalex.org/W2013510585","https://openalex.org/W2019372820","https://openalex.org/W2029046685","https://openalex.org/W2033674127","https://openalex.org/W2042795327","https://openalex.org/W2056609695","https://openalex.org/W2067161106","https://openalex.org/W2068648582","https://openalex.org/W2073353027","https://openalex.org/W2073994825","https://openalex.org/W2074809432","https://openalex.org/W2076934291","https://openalex.org/W2081610534","https://openalex.org/W2082121248","https://openalex.org/W2086660631","https://openalex.org/W2099300318","https://openalex.org/W2103638901","https://openalex.org/W2116627535","https://openalex.org/W2117571220","https://openalex.org/W2120385383","https://openalex.org/W2129983617","https://openalex.org/W2142626694","https://openalex.org/W2160624126","https://openalex.org/W2165777315","https://openalex.org/W2168454062","https://openalex.org/W2888511473","https://openalex.org/W4211204946","https://openalex.org/W4388298705"],"related_works":["https://openalex.org/W1990907154","https://openalex.org/W2254928904","https://openalex.org/W4400747582","https://openalex.org/W199137081","https://openalex.org/W1486921570","https://openalex.org/W2027146263","https://openalex.org/W1986539151","https://openalex.org/W4391275836","https://openalex.org/W6982588410","https://openalex.org/W1987307043"],"abstract_inverted_index":{"Human":[0],"calmodulin-like":[1],"protein":[2,8,40],"(CLP)":[3],"is":[4,11,19,147,175],"an":[5,176],"epithelial-specific":[6],"Ca(2+)-binding":[7],"whose":[9],"expression":[10],"strongly":[12,90],"down-regulated":[13],"in":[14,44,115,124,155,161,184],"cancers.":[15],"Like":[16],"calmodulin,":[17],"CLP":[18,77,88,119,133,146,178,188],"thought":[20],"to":[21,48,52,79,83,131,135,168],"regulate":[22],"cellular":[23,162],"processes":[24,163],"via":[25],"Ca(2+)-dependent":[26,46],"interactions":[27],"with":[28,91,121],"specific":[29,149],"target":[30],"proteins.":[31],"Using":[32],"gel":[33],"overlays,":[34],"we":[35],"identified":[36],"a":[37,45,58,136,148],"approximately":[38,96],"210-kDa":[39],"binding":[41,66,78],"specifically":[42],"and":[43,86,118,170,198],"manner":[47],"CLP,":[49],"but":[50],"not":[51],"calmodulin.":[53],"Yeast":[54],"two-hybrid":[55],"screening":[56],"yielded":[57],"CLP-interacting":[59],"clone":[60],"encoding":[61],"the":[62,80,112],"three":[63],"light":[64,150],"chain":[65,151],"IQ":[67,81,92],"motifs":[68],"of":[69,152],"human":[70],"\"unconventional\"":[71],"myosin":[72,106,122,153,173,181],"X.":[73],"Pull-down":[74],"experiments":[75],"showed":[76],"domain":[82],"be":[84],"direct":[85],"Ca(2+)-dependent.":[87],"interacted":[89],"motif":[93],"3":[94],"(K(d)":[95],"0.5":[97],"nm)":[98],"as":[99,191],"determined":[100],"by":[101],"surface":[102],"plasmon":[103],"resonance.":[104],"Epitope-tagged":[105],"X":[107,123,128,154,174,182],"was":[108,129],"localized":[109],"preferentially":[110],"at":[111],"cell":[113,171,196],"periphery":[114],"MCF-7":[116],"cells,":[117,143],"colocalized":[120],"these":[125],"cells.":[126],"Myosin":[127],"able":[130],"coprecipitate":[132],"and,":[134],"lesser":[137],"extent,":[138],"calmodulin":[139],"from":[140,165],"transfected":[141],"COS-1":[142],"indicating":[144],"that":[145],"vivo.":[156],"Because":[157],"unconventional":[158],"myosins":[159],"participate":[160],"ranging":[164],"membrane":[166],"trafficking":[167],"signaling":[169],"motility,":[172],"attractive":[177],"target.":[179],"Altered":[180],"regulation":[183],"(tumor)":[185],"cells":[186],"lacking":[187],"may":[189],"have":[190],"yet":[192],"unknown":[193],"consequences":[194],"for":[195],"growth":[197],"differentiation.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
