{"id":"https://openalex.org/W1968029163","doi":"https://doi.org/10.1007/s11910-001-0100-0","title":"Frontotemporal dementia and tauopathy","display_name":"Frontotemporal dementia and tauopathy","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W1968029163","doi":"https://doi.org/10.1007/s11910-001-0100-0","mag":"1968029163","pmid":"https://pubmed.ncbi.nlm.nih.gov/11898551"},"language":"en","primary_location":{"id":"doi:10.1007/s11910-001-0100-0","doi":"https://doi.org/10.1007/s11910-001-0100-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11910-001-0100-0","pdf_url":null,"source":{"id":"https://openalex.org/S136388143","display_name":"Current Neurology and Neuroscience Reports","issn_l":"1528-4042","issn":["1528-4042","1534-6293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neurology and Neuroscience Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041023169","display_name":"Yasumasa Yoshiyama","orcid":"https://orcid.org/0000-0002-7992-7436","observed_orcids":["https://orcid.org/0000-0002-7992-7436"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasumasa Yoshiyama","raw_affiliation_strings":["Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M-Y Lee","raw_affiliation_strings":["Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, 19104, Philadelphia, PA, USA","Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, 19104, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Q. Trojanowski","raw_affiliation_strings":["Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, 19104, Philadelphia, PA, USA","Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, 3rd Floor Maloney, 19104, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Neurodegenerative Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":5590,"currency":"USD","value_usd":5590},"apc_paid":null,"fwci":0.0891,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.05391304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":"5","first_page":"413","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7289999723434448},{"id":"https://openalex.org/keywords/hyperphosphorylated-tau","display_name":"hyperphosphorylated tau","score":0.8709999918937683},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ftdp-17","display_name":"FTDP-17","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tau-gene-mutations","display_name":"tau gene mutations","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sporadic-frontotemporal-dementia","display_name":"sporadic frontotemporal dementia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6209999918937683},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.890999972820282},{"id":"https://openalex.org/keywords/therapeutic-interventions","display_name":"therapeutic interventions","score":0.578000009059906},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.9502793550491333},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.8884849548339844},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.6764420866966248},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.660483181476593},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5568010807037354},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5181626081466675},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.4908793568611145},{"id":"https://openalex.org/C2776936178","wikidata":"https://www.wikidata.org/wiki/Q1755684","display_name":"Corticobasal degeneration","level":4,"score":0.41232794523239136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3978308141231537},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3570176362991333},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3383612632751465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30445796251296997},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2962387800216675},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2768491506576538}],"mesh":[{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11910-001-0100-0","doi":"https://doi.org/10.1007/s11910-001-0100-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11910-001-0100-0","pdf_url":null,"source":{"id":"https://openalex.org/S136388143","display_name":"Current Neurology and Neuroscience Reports","issn_l":"1528-4042","issn":["1528-4042","1534-6293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neurology and Neuroscience Reports","raw_type":"journal-article"},{"id":"pmid:11898551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11898551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current neurology and neuroscience reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1480786153","https://openalex.org/W1565807488","https://openalex.org/W1957167348","https://openalex.org/W1970634015","https://openalex.org/W1985703940","https://openalex.org/W1986349982","https://openalex.org/W1987844942","https://openalex.org/W1992423329","https://openalex.org/W1992589625","https://openalex.org/W1992973287","https://openalex.org/W1999486169","https://openalex.org/W2001113634","https://openalex.org/W2002164075","https://openalex.org/W2005311608","https://openalex.org/W2009945323","https://openalex.org/W2018890759","https://openalex.org/W2021590064","https://openalex.org/W2024941524","https://openalex.org/W2025391244","https://openalex.org/W2026852774","https://openalex.org/W2030804652","https://openalex.org/W2034300008","https://openalex.org/W2035156043","https://openalex.org/W2037431629","https://openalex.org/W2040661002","https://openalex.org/W2051233811","https://openalex.org/W2054933404","https://openalex.org/W2065032350","https://openalex.org/W2067177341","https://openalex.org/W2070244991","https://openalex.org/W2075188811","https://openalex.org/W2075530100","https://openalex.org/W2077699648","https://openalex.org/W2081451333","https://openalex.org/W2082184509","https://openalex.org/W2083460373","https://openalex.org/W2089364726","https://openalex.org/W2105830106","https://openalex.org/W2116982426","https://openalex.org/W2120178938","https://openalex.org/W2125823125","https://openalex.org/W2139553041","https://openalex.org/W2143604549","https://openalex.org/W2153935131","https://openalex.org/W2154364607","https://openalex.org/W2164891060","https://openalex.org/W2169082772","https://openalex.org/W2327267141","https://openalex.org/W2418501929","https://openalex.org/W4238710838","https://openalex.org/W4251309349","https://openalex.org/W4254653452"],"related_works":["https://openalex.org/W92160486","https://openalex.org/W1974343562","https://openalex.org/W47608607","https://openalex.org/W2170741797","https://openalex.org/W2023296235","https://openalex.org/W1971918480","https://openalex.org/W1979752653","https://openalex.org/W4251423372","https://openalex.org/W2138050503","https://openalex.org/W246954625"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}