{"id":"https://openalex.org/W1968016381","doi":"https://doi.org/10.1371/journal.pone.0084565","title":"Increased Functional Connectivity between Prefrontal Cortex and Reward System in Pathological Gambling","display_name":"Increased Functional Connectivity between Prefrontal Cortex and Reward System in Pathological Gambling","publication_year":2013,"publication_date":"2013-12-19","ids":{"openalex":"https://openalex.org/W1968016381","doi":"https://doi.org/10.1371/journal.pone.0084565","mag":"1968016381","pmid":"https://pubmed.ncbi.nlm.nih.gov/24367675","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868704"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0084565","doi":"https://doi.org/10.1371/journal.pone.0084565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0084565","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084565&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084565&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004333810","display_name":"Saskia Koehler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Saskia Koehler","raw_affiliation_strings":["Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9 Campus Mitte, Berlin, Germany ; Department of Psychology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","Berlin School of Mind and Brain, Humboldt University Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9 Campus Mitte, Berlin, Germany ; Department of Psychology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210130445","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Berlin School of Mind and Brain, Humboldt University Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087452321","display_name":"Smadar Ovadia\u2010Caro","orcid":"https://orcid.org/0000-0002-1688-5080","observed_orcids":["https://orcid.org/0000-0002-1688-5080"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Smadar Ovadia-Caro","raw_affiliation_strings":["Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society","Department of Cognitive Psychology, Humboldt University Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Department of Cognitive Psychology, Humboldt University Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111916781","display_name":"Elke E. van der Meer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elke van der Meer","raw_affiliation_strings":["Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Department of Cognitive Psychology, Humboldt University Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychology, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Department of Cognitive Psychology, Humboldt University Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020270555","display_name":"Arno Villringer","orcid":"https://orcid.org/0000-0003-2604-2404","observed_orcids":["https://orcid.org/0000-0003-2604-2404"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arno Villringer","raw_affiliation_strings":["Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","Berlin School of Mind and Brain, Humboldt, University Berlin, Germany","Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Berlin School of Mind and Brain, Humboldt, University Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000701045","display_name":"Andreas Heinz","orcid":"https://orcid.org/0000-0001-5405-9065","observed_orcids":["https://orcid.org/0000-0001-5405-9065"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Heinz","raw_affiliation_strings":["Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9 Campus Mitte, Berlin, Germany","Berlin School of Mind and Brain, Humboldt University Berlin, Germany","Department of Psychiatry and Psychotherapy, Charit\u00e9 University Medicine Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9 Campus Mitte, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Berlin School of Mind and Brain, Humboldt University Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9 University Medicine Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017364275","display_name":"Nina Romanczuk\u2010Seiferth","orcid":"https://orcid.org/0000-0002-6931-269X","observed_orcids":["https://orcid.org/0000-0002-6931-269X"]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nina Romanczuk-Seiferth","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9 Campus Mitte, Berlin, Germany","Department of Psychiatry and Psychotherapy,Charit\u00e9 University Medicine Berlin,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9 Campus Mitte, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy,Charit\u00e9 University Medicine Berlin,Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020214490","display_name":"Daniel S. Margulies","orcid":"https://orcid.org/0000-0002-8880-9204","observed_orcids":["https://orcid.org/0000-0002-8880-9204"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel S. Margulies","raw_affiliation_strings":["Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","Berlin School of Mind and Brain, Humboldt, University Berlin, Germany","Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin School of Mind and Brain and the Mind-Brain Institute, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany ; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Berlin School of Mind and Brain, Humboldt, University Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004333810"],"corresponding_institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210130445","https://openalex.org/I7877124"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":1133,"currency":"EUR","value_usd":1221},"fwci":7.445,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.97076392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"8","issue":"12","first_page":"e84565","last_page":"e84565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11705","display_name":"Gambling Behavior and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11705","display_name":"Gambling Behavior and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gambling-disorder","display_name":"gambling addiction","score":1.0},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mesolimbic-reward-system","display_name":"mesolimbic reward system","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ventral-striatum","display_name":"ventral striatum","score":0.9520000219345093},{"id":"https://openalex.org/keywords/middle-frontal-gyrus","display_name":"middle frontal gyrus","score":0.984000027179718},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9879999756813049},{"id":"https://openalex.org/keywords/impulsivity","display_name":"impulsivity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7450000047683716},{"id":"https://openalex.org/keywords/craving","display_name":"craving","score":0.9259999990463257},{"id":"https://openalex.org/keywords/behavioral-addiction","display_name":"behavioral addiction","score":0.8560000061988831},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7467961311340332},{"id":"https://openalex.org/C2779991468","wikidata":"https://www.wikidata.org/wiki/Q3063753","display_name":"Middle frontal gyrus","level":3,"score":0.7249866724014282},{"id":"https://openalex.org/C2775956885","wikidata":"https://www.wikidata.org/wiki/Q3064113","display_name":"Superior frontal gyrus","level":3,"score":0.7063934206962585},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6975439190864563},{"id":"https://openalex.org/C2776743251","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Ventral striatum","level":4,"score":0.6886017322540283},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6693456172943115},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.567257821559906},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.5261659026145935},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.49209994077682495},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.49036693572998047},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.48668819665908813},{"id":"https://openalex.org/C2781423396","wikidata":"https://www.wikidata.org/wiki/Q1558534","display_name":"Inferior frontal gyrus","level":3,"score":0.4786873459815979},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.4616606831550598},{"id":"https://openalex.org/C2780621315","wikidata":"https://www.wikidata.org/wiki/Q5407200","display_name":"Middle temporal gyrus","level":3,"score":0.46152961254119873},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.43503010272979736},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4004523754119873},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.1364285945892334},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.11238059401512146}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005715","descriptor_name":"Gambling","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005715","descriptor_name":"Gambling","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D057566","descriptor_name":"Self Report","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0084565","doi":"https://doi.org/10.1371/journal.pone.0084565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0084565","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084565&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2853987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868704","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24367675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24367675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3868704","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3868704/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.811.682","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.811.682","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/51/4a/pone.0084565.PMC3868704.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1ddcdd6dc36f49f3a7f71fb565cbc4d1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1ddcdd6dc36f49f3a7f71fb565cbc4d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 12, p e84565 (2013)","raw_type":"article"},{"id":"pmh:oai:escidoc.org:escidoc:1878153","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0014-CF78-3","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/882553","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Increased_Functional_Connectivity_between_Prefrontal_Cortex_and_Reward_System_in_Pathological_Gambling_/882553","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_1878153","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0014-CF78-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0084565","doi":"https://doi.org/10.1371/journal.pone.0084565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0084565","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084565&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1001580182","display_name":null,"funder_award_id":"HE 2597/4","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G105873016","display_name":null,"funder_award_id":"01QG87164","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G1314900919","display_name":"Verbundprojekt: Bernstein-Zentrum f\u00fcr Computational Neuroscience, Berlin (CCNB): Teilprojekte: A2, B2, C1, C3","funder_award_id":"01GQ0411","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G19457306","display_name":null,"funder_award_id":"HE 2597/4-3","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3584538239","display_name":null,"funder_award_id":"EXC257","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5039939568","display_name":null,"funder_award_id":"01QG87164","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6097946119","display_name":"Verbundprojekt: Genetik der Alkoholsucht - Teilprojekt 1, 7, 8, 9, 11, 13, 14, 15","funder_award_id":"01GS08152","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8093809147","display_name":null,"funder_award_id":"01GQ0411","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G945271039","display_name":null,"funder_award_id":"STE 1430/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320320878","display_name":"Minerva Foundation","ror":"https://ror.org/02rxjts25"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320338413","display_name":"Cilag","ror":"https://ror.org/02fe4h741"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968016381.pdf","grobid_xml":"https://content.openalex.org/works/W1968016381.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1506726456","https://openalex.org/W1968369609","https://openalex.org/W1970695058","https://openalex.org/W1973967428","https://openalex.org/W1977599051","https://openalex.org/W1982336939","https://openalex.org/W1983336654","https://openalex.org/W1984875915","https://openalex.org/W1985516139","https://openalex.org/W1986350274","https://openalex.org/W1987110004","https://openalex.org/W1991448902","https://openalex.org/W1996186724","https://openalex.org/W1997839536","https://openalex.org/W2000400885","https://openalex.org/W2004026761","https://openalex.org/W2005151333","https://openalex.org/W2010194799","https://openalex.org/W2011003381","https://openalex.org/W2020005121","https://openalex.org/W2021986306","https://openalex.org/W2025387215","https://openalex.org/W2025996975","https://openalex.org/W2026871932","https://openalex.org/W2033765091","https://openalex.org/W2036959087","https://openalex.org/W2047713573","https://openalex.org/W2049969463","https://openalex.org/W2054515032","https://openalex.org/W2055506938","https://openalex.org/W2066447422","https://openalex.org/W2070900017","https://openalex.org/W2071245860","https://openalex.org/W2071300176","https://openalex.org/W2078530990","https://openalex.org/W2079450984","https://openalex.org/W2082014247","https://openalex.org/W2083053387","https://openalex.org/W2083386892","https://openalex.org/W2084423544","https://openalex.org/W2085092576","https://openalex.org/W2085416233","https://openalex.org/W2086260698","https://openalex.org/W2089030269","https://openalex.org/W2098337487","https://openalex.org/W2106315421","https://openalex.org/W2106600012","https://openalex.org/W2108983720","https://openalex.org/W2110233084","https://openalex.org/W2116905575","https://openalex.org/W2118755615","https://openalex.org/W2119041204","https://openalex.org/W2119285123","https://openalex.org/W2120546516","https://openalex.org/W2122039482","https://openalex.org/W2123110589","https://openalex.org/W2123197200","https://openalex.org/W2136022845","https://openalex.org/W2138905229","https://openalex.org/W2139842122","https://openalex.org/W2145702255","https://openalex.org/W2147156351","https://openalex.org/W2149495603","https://openalex.org/W2150037871","https://openalex.org/W2151137320","https://openalex.org/W2153554101","https://openalex.org/W2159011576","https://openalex.org/W2163336830","https://openalex.org/W2167420848","https://openalex.org/W2332843004","https://openalex.org/W2412261760"],"related_works":["https://openalex.org/W7095434623","https://openalex.org/W2310647408","https://openalex.org/W6924875669","https://openalex.org/W2049969463","https://openalex.org/W2085092576","https://openalex.org/W1999463885","https://openalex.org/W4385752244","https://openalex.org/W1991448902","https://openalex.org/W2034523694","https://openalex.org/W2153554101"],"abstract_inverted_index":{"Pathological":[0],"gambling":[1],"(PG)":[2],"shares":[3],"clinical":[4],"characteristics":[5],"with":[6,71,135,202,220],"substance-use":[7],"disorders":[8],"and":[9,28,73,98,107,141,179,183,226],"is":[10,50],"thus":[11],"discussed":[12],"as":[13,126,164,189],"a":[14,88],"behavioral":[15],"addiction.":[16],"Recent":[17],"neuroimaging":[18],"studies":[19],"on":[20,84],"PG":[21,49,72,111,146,149,187,206,219],"report":[22],"functional":[23,64,76,216],"changes":[24,233],"in":[25,48,52,68,94,144,186,204,215,218,235],"prefrontal":[26,96,162,224],"structures":[27,38],"the":[29,53,85,95,99,117,123,145,155,176,197,205,227],"mesolimbic":[30,100],"reward":[31,101,228],"system.":[32],"While":[33],"an":[34],"imbalance":[35],"between":[36,55,223],"these":[37],"has":[39],"been":[40],"related":[41],"to":[42,122,128,160,166,175,191,196,231],"addictive":[43],"behavior,":[44],"whether":[45],"their":[46],"dysfunction":[47],"reflected":[51],"interaction":[54],"them":[56],"remains":[57],"unclear.":[58],"We":[59],"addressed":[60],"this":[61],"question":[62],"using":[63,80],"connectivity":[65,77,115,153,174,195,217,222,232],"resting-state":[66],"fMRI":[67],"male":[69],"subjects":[70],"controls.":[74,167,192],"Seed-based":[75],"was":[78,131,199],"computed":[79],"two":[81],"regions-of-interest,":[82],"based":[83],"results":[86,209],"of":[87,138],"previous":[89],"voxel-based":[90],"morphometry":[91],"study,":[92],"located":[93],"cortex":[97],"system":[102],"(right":[103],"middle":[104,119,157,180],"frontal":[105,120,158,181],"gyrus":[106,121,159,182],"right":[108,118,124,156,169,177],"ventral":[109,170],"striatum).":[110],"patients":[112,150,188],"demonstrated":[113,151,172],"increased":[114,173,194,221],"from":[116,154],"striatum":[125,171],"compared":[127,165,190],"controls,":[129],"which":[130],"also":[132],"positively":[133,200],"correlated":[134,201],"nonplanning":[136],"aspect":[137],"impulsiveness,":[139],"smoking":[140,203],"craving":[142],"scores":[143],"group.":[147,207],"Moreover,":[148],"decreased":[152],"other":[161],"areas":[163],"The":[168,193],"superior":[178],"left":[184],"cerebellum":[185,198],"Our":[208],"provide":[210],"further":[211],"evidence":[212],"for":[213],"alterations":[214],"regions":[225],"system,":[229],"similar":[230],"reported":[234],"substance":[236],"use":[237],"disorder.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}