{"id":"https://openalex.org/W1968005305","doi":"https://doi.org/10.4161/nucl.2.4.16506","title":"Losing control","display_name":"Losing control","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W1968005305","doi":"https://doi.org/10.4161/nucl.2.4.16506","mag":"1968005305","pmid":"https://pubmed.ncbi.nlm.nih.gov/21941112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260564"},"language":"en","primary_location":{"id":"doi:10.4161/nucl.2.4.16506","doi":"https://doi.org/10.4161/nucl.2.4.16506","is_oa":true,"landing_page_url":"https://doi.org/10.4161/nucl.2.4.16506","pdf_url":null,"source":{"id":"https://openalex.org/S200139231","display_name":"Nucleus","issn_l":"1949-1034","issn":["1949-1034","1949-1042"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/nucl.2.4.16506","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030273254","display_name":"Indika Rajapakse","orcid":"https://orcid.org/0000-0001-6160-9168","observed_orcids":["https://orcid.org/0000-0001-6160-9168","https://orcid.org/0000-0003-4664-1439"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indika Rajapakse","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073932551","display_name":"David Scalzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Scalzo","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA","Fred Hutchinson Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062846476","display_name":"Mark T. Groudine","orcid":"https://orcid.org/0000-0002-1116-2588","observed_orcids":["https://orcid.org/0000-0002-1116-2588"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Groudine","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA. Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA. Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062846476"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":{"value":1625,"currency":"GBP","value_usd":1993},"apc_paid":{"value":1625,"currency":"GBP","value_usd":1993},"fwci":0.2176,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57166585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"4","first_page":"249","last_page":"252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.8989999890327454},{"id":"https://openalex.org/keywords/complex-systems","display_name":"complex systems","score":0.5389999747276306},{"id":"https://openalex.org/keywords/emergent-properties","display_name":"emergent properties","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.42800000309944153},{"id":"https://openalex.org/keywords/premalignant-cells","display_name":"premalignant cells","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.660493016242981},{"id":"https://openalex.org/C177606310","wikidata":"https://www.wikidata.org/wiki/Q5674297","display_name":"Adaptability","level":2,"score":0.6341106295585632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5580028891563416},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.5523678064346313},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5363458395004272},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5301412343978882},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5141913890838623},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45914268493652344},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37879589200019836},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3702812194824219},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31055551767349243},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2902231812477112},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1556057631969452},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/nucl.2.4.16506","doi":"https://doi.org/10.4161/nucl.2.4.16506","is_oa":true,"landing_page_url":"https://doi.org/10.4161/nucl.2.4.16506","pdf_url":null,"source":{"id":"https://openalex.org/S200139231","display_name":"Nucleus","issn_l":"1949-1034","issn":["1949-1034","1949-1042"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3260564","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260564","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleus","raw_type":"Text"},{"id":"pmid:21941112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21941112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleus (Austin, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/nucl.2.4.16506","doi":"https://doi.org/10.4161/nucl.2.4.16506","is_oa":true,"landing_page_url":"https://doi.org/10.4161/nucl.2.4.16506","pdf_url":null,"source":{"id":"https://openalex.org/S200139231","display_name":"Nucleus","issn_l":"1949-1034","issn":["1949-1034","1949-1042"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1126570101","display_name":"Quantitative models and methods for genetic organization","funder_award_id":"K25DK082791","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4766655752","display_name":"Function of human & mouse Beta-globin locus control regions","funder_award_id":"R37DK044746","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5458765616","display_name":"Activation and Silencing of Gene Expression during Cellular Differentiation","funder_award_id":"R01HL065440","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1505062451","https://openalex.org/W1963649370","https://openalex.org/W1975446378","https://openalex.org/W2007325090","https://openalex.org/W2029030701","https://openalex.org/W2032794174","https://openalex.org/W2053437486","https://openalex.org/W2064568975","https://openalex.org/W2097603708","https://openalex.org/W2109948920","https://openalex.org/W2117692326","https://openalex.org/W2127439151","https://openalex.org/W2141269919","https://openalex.org/W2164912629","https://openalex.org/W2165664339","https://openalex.org/W2605543710"],"related_works":["https://openalex.org/W2794532755","https://openalex.org/W4390622589","https://openalex.org/W7223134493","https://openalex.org/W1969676039","https://openalex.org/W6960119543","https://openalex.org/W2592635005","https://openalex.org/W2956109456","https://openalex.org/W7096537178","https://openalex.org/W2113605459","https://openalex.org/W152219304"],"abstract_inverted_index":{"Adaptability":[0],"and":[1,44,70],"\"emergent\"":[2],"properties":[3],"are":[4],"the":[5],"dominant":[6],"characteristics":[7],"of":[8,24,28,38,41,54,59,63,119],"complex":[9,18],"systems,":[10],"whether":[11],"naturally":[12],"occurring":[13],"or":[14,31],"engineered.":[15],"Structurally,":[16],"a":[17,25,49,55,130],"system":[19],"might":[20,33],"be":[21,34],"made":[22],"up":[23],"large":[26],"number":[27],"simpler":[29],"components,":[30],"it":[32],"formed":[35],"from":[36,115,129],"hierarchies":[37],"smaller":[39],"numbers":[40],"interacting":[42],"subsystems":[43],"work":[45,96],"together":[46],"to":[47],"produce":[48],"defined":[50],"function.":[51],"The":[52,74],"nucleus":[53],"cell":[56],"has":[57,102],"all":[58],"these":[60],"features,":[61],"many":[62],"which":[64],"may":[65],"become":[66,85,92],"disrupted":[67],"in":[68],"cancer":[69,79,105,117,125],"other":[71],"disease":[72],"states.":[73],"general":[75],"view":[76],"is":[77],"that":[78,104,124,134],"progresses":[80],"gradually":[81],"over":[82],"time;":[83],"cells":[84],"premalignant,":[86],"then":[87],"increasingly":[88],"abnormal":[89],"before":[90],"they":[91,122],"cancerous.":[93],"However,":[94],"recent":[95],"by":[97],"Stephens":[98],"et":[99],"al.":[100],"(2011)":[101],"revealed":[103],"can":[106,126],"emerge":[107],"much":[108],"more":[109],"rapidly.":[110],"Based":[111],"on":[112],"DNA":[113],"sequences":[114],"multiple":[116],"samples":[118],"various":[120],"types,":[121],"show":[123],"arise":[127],"suddenly":[128],"single":[131],"catastrophic":[132],"event":[133],"causes":[135],"massive":[136],"genomic":[137],"rearrangement.":[138]},"counts_by_year":[{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
