{"id":"https://openalex.org/W1967988409","doi":"https://doi.org/10.1002/jbt.2570050205","title":"Metabolism of methacrylonitrile to cyanide: In vitro studies","display_name":"Metabolism of methacrylonitrile to cyanide: In vitro studies","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W1967988409","doi":"https://doi.org/10.1002/jbt.2570050205","mag":"1967988409","pmid":"https://pubmed.ncbi.nlm.nih.gov/2283659"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.2570050205","doi":"https://doi.org/10.1002/jbt.2570050205","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.2570050205","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007532089","display_name":"Mohammed Y. H. Farooqui","orcid":"https://orcid.org/0000-0002-1358-1751","observed_orcids":["https://orcid.org/0000-0002-1358-1751"]},"institutions":[{"id":"https://openalex.org/I16452829","display_name":"The University of Texas System","ror":"https://ror.org/01gek1696","country_code":"US","type":"education","lineage":["https://openalex.org/I16452829"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohammed Y. H. Farooqui","raw_affiliation_strings":["Department of Biological Sciences, University of Texas Pan American, Edinburg 78539","Division of Environmental Toxicology, Department of Biological Sciences, The University of Texas Pan American, Edinburg, Texas 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Texas Pan American, Edinburg 78539","institution_ids":["https://openalex.org/I16452829"]},{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, The University of Texas Pan American, Edinburg, Texas 78539, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016952340","display_name":"R. G. Diaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolando G. Diaz","raw_affiliation_strings":["Division of Environmental Toxicology, Department of Biological Sciences, The University of Texas Pan American, Edinburg, Texas 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, The University of Texas Pan American, Edinburg, Texas 78539, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018101289","display_name":"Rogelio Cavazos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rogelio Cavazos","raw_affiliation_strings":["Division of Environmental Toxicology, Department of Biological Sciences, The University of Texas Pan American, Edinburg, Texas 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, The University of Texas Pan American, Edinburg, Texas 78539, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007532089"],"corresponding_institution_ids":["https://openalex.org/I16452829"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":1.6079,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80062245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"109","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methacrylonitrile","display_name":"methacrylonitrile","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyanide","display_name":"cyanide","score":0.7509999871253967},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mixed-function-oxidase","display_name":"mixed function oxidase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nadph-dependent-metabolism","display_name":"NADPH-dependent metabolism","score":0.7850000262260437},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.7540000081062317},{"id":"https://openalex.org/keywords/epoxide-hydrolase","display_name":"epoxide hydrolase","score":0.6980000138282776},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.800000011920929},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.6690000295639038},{"id":"https://openalex.org/keywords/penicillamine","display_name":"D-penicillamine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/2-mercaptoethanol","display_name":"2-mercaptoethanol","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7716869115829468},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7605120539665222},{"id":"https://openalex.org/C2780282147","wikidata":"https://www.wikidata.org/wiki/Q2088171","display_name":"Methacrylonitrile","level":5,"score":0.6745309829711914},{"id":"https://openalex.org/C2778455166","wikidata":"https://www.wikidata.org/wiki/Q55076544","display_name":"Cyanide","level":2,"score":0.6581780910491943},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5962396264076233},{"id":"https://openalex.org/C2777989768","wikidata":"https://www.wikidata.org/wiki/Q28747","display_name":"Nicotinamide adenine dinucleotide phosphate","level":4,"score":0.5834379196166992},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5425506234169006},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.49714091420173645},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.48440247774124146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46320807933807373},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.4535946249961853},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.4286673069000244},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4127000570297241},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3240400552749634},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16542106866836548},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C2778372188","wikidata":"https://www.wikidata.org/wiki/Q342968","display_name":"Acrylonitrile","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011335","descriptor_name":"Proadifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.2570050205","doi":"https://doi.org/10.1002/jbt.2570050205","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.2570050205","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical Toxicology","raw_type":"journal-article"},{"id":"pmid:2283659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2283659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3567808094","display_name":"MBRS PROGRAM AT PAN AMERICAN UNIVERSITY","funder_award_id":"S06RR008038","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4445292770","display_name":null,"funder_award_id":"SO6RR08038","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W170802050","https://openalex.org/W1515756335","https://openalex.org/W1532760517","https://openalex.org/W1574643837","https://openalex.org/W1584235297","https://openalex.org/W1606916058","https://openalex.org/W1751485187","https://openalex.org/W1855801337","https://openalex.org/W1951469402","https://openalex.org/W1966496220","https://openalex.org/W1978979175","https://openalex.org/W1990514914","https://openalex.org/W1998450236","https://openalex.org/W2010027572","https://openalex.org/W2010429599","https://openalex.org/W2094773643","https://openalex.org/W2128635872","https://openalex.org/W2130113110","https://openalex.org/W2142581288","https://openalex.org/W2274006222","https://openalex.org/W2369753003","https://openalex.org/W2434385284","https://openalex.org/W3008471499","https://openalex.org/W4206478798","https://openalex.org/W4234152194","https://openalex.org/W4297756632","https://openalex.org/W4321429512"],"related_works":["https://openalex.org/W1751485187","https://openalex.org/W2470846086","https://openalex.org/W2036493759","https://openalex.org/W1481721518","https://openalex.org/W1996241479","https://openalex.org/W2330972578","https://openalex.org/W2038707749","https://openalex.org/W4250406820","https://openalex.org/W2415966397","https://openalex.org/W1821087693"],"abstract_inverted_index":{"In":[0],"liver":[1],"fractions":[2],"from":[3,59,91,105],"male":[4],"Sprague-Dawley":[5],"rats,":[6],"the":[7,80,87,101],"metabolism":[8],"of":[9,35,52,63,79,89,94,103],"methacrylonitrile":[10],"(MeAN)":[11],"to":[12,37,43,114],"cyanide":[13],"(CN-)":[14],"was":[15,39,54],"localized":[16],"in":[17,56],"microsomal":[18,45],"fraction":[19],"and":[20,28,49,65,69,75,98],"required":[21],"reduced":[22],"nicotinamide":[23],"adenine":[24],"dinucleotide":[25],"phosphate":[26],"(NADPH)":[27],"oxygen":[29],"for":[30],"maximal":[31],"activity.":[32],"The":[33],"biotransformation":[34],"MeAN":[36,53,111],"CN-":[38,90,104,115],"characterized":[40],"with":[41,67],"respect":[42],"time,":[44],"protein":[46],"concentration,":[47],"pH,":[48],"temperature.":[50],"Metabolism":[51],"increased":[55],"microsomes":[57],"obtained":[58],"phenobarbital-treated":[60],"rats":[61],"(310%":[62],"control)":[64],"decreased":[66,86],"CoCl2":[68],"SKF":[70],"525":[71],"A":[72],"treatments":[73],"(55%":[74],"61%,":[76],"respectively).":[77],"Addition":[78,93],"epoxide":[81],"hydratase":[82],"inhibitor,":[83],"1,1,1-trichloropropane":[84],"2,3-oxide,":[85],"formation":[88],"MeAN.":[92,106],"glutathione,":[95],"cysteine,":[96],"D-penicillamine,":[97],"2-mercaptoethanol":[99],"enhanced":[100],"released":[102],"These":[107],"findings":[108],"indicate":[109],"that":[110],"is":[112],"metabolized":[113],"via":[116],"a":[117],"cytochrome":[118],"P-450-dependent":[119],"mixed-function":[120],"oxidase":[121],"system.":[122]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}