{"id":"https://openalex.org/W1967978968","doi":"https://doi.org/10.1055/s-2006-933310","title":"Vascular Biology: Cellular and Molecular Profiling","display_name":"Vascular Biology: Cellular and Molecular Profiling","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1967978968","doi":"https://doi.org/10.1055/s-2006-933310","mag":"1967978968","pmid":"https://pubmed.ncbi.nlm.nih.gov/16479445"},"language":"en","primary_location":{"id":"doi:10.1055/s-2006-933310","doi":"https://doi.org/10.1055/s-2006-933310","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-933310","pdf_url":null,"source":{"id":"https://openalex.org/S144243704","display_name":"Seminars in Neurology","issn_l":"0271-8235","issn":["0271-8235","1098-9021"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112760395","display_name":"Alison E. Baird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison E Baird","raw_affiliation_strings":["Stroke Neuroscience Unit, NINDS/NIH, Bethesda, MD 20814, USA","Stroke Neuroscience Unit, NINDS/NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Neuroscience Unit, NINDS/NIH, Bethesda, MD 20814, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Stroke Neuroscience Unit, NINDS/NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090251996","display_name":"Violet Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Violet L Wright","raw_affiliation_strings":["Stroke Neuroscience Unit, NINDS/NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Neuroscience Unit, NINDS/NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.244,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6389332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"26","issue":"01","first_page":"065","last_page":"074"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-atherosclerosis","display_name":"cerebral atherosclerosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cd4-cd28-t-cells","display_name":"CD4+CD28- T cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/endothelial-microparticles","display_name":"endothelial microparticles","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.847000002861023},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.8809999823570251},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7137911915779114},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.589145839214325},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5878945589065552},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5553815364837646},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5342708230018616},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5202839970588684},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4574718475341797},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4562666416168213},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.44338905811309814},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4190126061439514},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3605932593345642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3294064998626709},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3196249306201935},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3096643388271332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2832023799419403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21850374341011047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19024771451950073},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.15561729669570923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09754407405853271},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2006-933310","doi":"https://doi.org/10.1055/s-2006-933310","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-933310","pdf_url":null,"source":{"id":"https://openalex.org/S144243704","display_name":"Seminars in Neurology","issn_l":"0271-8235","issn":["0271-8235","1098-9021"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Neurology","raw_type":"journal-article"},{"id":"pmid:16479445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16479445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1968754191","https://openalex.org/W4280565637","https://openalex.org/W1837173688","https://openalex.org/W7099620861","https://openalex.org/W2266541449","https://openalex.org/W2041981464","https://openalex.org/W4388797608","https://openalex.org/W4365483412","https://openalex.org/W2965125792","https://openalex.org/W7096223144"],"abstract_inverted_index":{"Our":[0],"understanding":[1],"of":[2,37,48,65,89,106,124,133,143,151,156,167],"the":[3,20,38,125,128,152,162,165],"mechanisms":[4],"underlying":[5],"cerebrovascular":[6],"atherosclerosis":[7],"has":[8],"improved":[9],"in":[10,26,86,96],"recent":[11,42],"years,":[12],"but":[13],"significant":[14],"gaps":[15],"remain.":[16],"New":[17],"insights":[18],"into":[19],"vascular":[21,108],"biological":[22],"processes":[23],"that":[24,120,140],"result":[25],"ischemic":[27,72],"stroke":[28,60,73,82,97,144,174],"may":[29,69,137,159],"come":[30],"from":[31],"cellular":[32,43],"and":[33,62,74,83,117,127,135,147,155,172],"molecular":[34,148],"profiling":[35,44,111,116,149],"studies":[36,150],"peripheral":[39,153],"blood.":[40],"In":[41],"studies,":[45],"increased":[46,107],"levels":[47],"a":[49,76,104],"proinflammatory":[50],"T-cell":[51,67],"subset":[52,68],"(CD4":[53],"(+)CD28":[54],"(-))":[55],"have":[56,93],"been":[57,94],"associated":[58],"with":[59],"recurrence":[61],"death.":[63,84],"Expansion":[64],"this":[66],"occur":[70],"after":[71],"be":[75,138],"pathogenic":[77],"mechanism":[78],"leading":[79],"to":[80,100],"recurrent":[81],"Increases":[85],"certain":[87],"phenotypes":[88],"endothelial":[90],"cell":[91],"microparticles":[92],"found":[95],"patients":[98],"relative":[99],"controls,":[101],"possibly":[102],"indicating":[103],"state":[105],"risk.":[109,145],"Molecular":[110],"approaches":[112],"include":[113],"gene":[114],"expression":[115],"proteomic":[118],"methods":[119],"permit":[121],"large-scale":[122],"analyses":[123],"transcriptome":[126],"proteome,":[129],"respectively.":[130],"Ultimately":[131],"panels":[132],"genes":[134],"proteins":[136],"identified":[139],"are":[141],"predictive":[142],"Cellular":[146],"blood":[154],"atherosclerotic":[157],"plaques":[158],"also":[160],"pave":[161],"way":[163],"for":[164,170],"development":[166],"therapeutic":[168],"agents":[169],"primary":[171],"secondary":[173],"prevention.":[175]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}