{"id":"https://openalex.org/W1967978337","doi":"https://doi.org/10.1097/qai.0b013e31815dbf7f","title":"Virologic Determinants of Success After Structured Treatment Interruptions of Antiretrovirals in Acute HIV-1 Infection","display_name":"Virologic Determinants of Success After Structured Treatment Interruptions of Antiretrovirals in Acute HIV-1 Infection","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W1967978337","doi":"https://doi.org/10.1097/qai.0b013e31815dbf7f","mag":"1967978337","pmid":"https://pubmed.ncbi.nlm.nih.gov/18300365"},"language":"en","primary_location":{"id":"doi:10.1097/qai.0b013e31815dbf7f","doi":"https://doi.org/10.1097/qai.0b013e31815dbf7f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qai.0b013e31815dbf7f","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062645957","display_name":"Sharon R. Lewin","orcid":"https://orcid.org/0000-0002-0330-8241","observed_orcids":["https://orcid.org/0000-0002-0330-8241"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210094512","display_name":"Albion Centre","ror":"https://ror.org/0066jxm83","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210094512"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sharon R Lewin","raw_affiliation_strings":["Albion Street Centre, Sydney, Australia","Department of Medicine, Monash University, Melbourne, Australia","Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albion Street Centre, Sydney, Australia","institution_ids":["https://openalex.org/I4210094512"]},{"raw_affiliation_string":"Department of Medicine, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia","institution_ids":["https://openalex.org/I2801993434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008902850","display_name":"John Michael Murray","orcid":"https://orcid.org/0000-0001-9314-2283","observed_orcids":["https://orcid.org/0000-0001-9314-2283"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John M Murray","raw_affiliation_strings":["National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","School of Mathematics and Statistics, University of New South Wales, Sydney, Australia","University Of New south Wales"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Mathematics and Statistics, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"University Of New south Wales","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110356286","display_name":"Ajantha E. Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ajantha Solomon","raw_affiliation_strings":["Department of Medicine, Monash University, Melbourne, Australia","Medicine Alfred Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Medicine Alfred Hospital","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059453915","display_name":"Fiona Wightman","orcid":"https://orcid.org/0000-0003-1203-1325","observed_orcids":["https://orcid.org/0000-0003-1203-1325"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fiona Wightman","raw_affiliation_strings":["Department of Medicine, Monash University, Melbourne, Australia","Medicine Alfred Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Medicine Alfred Hospital","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055398640","display_name":"Paul U. Cameron","orcid":"https://orcid.org/0000-0002-1906-6945","observed_orcids":["https://orcid.org/0000-0002-1906-6945"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210094512","display_name":"Albion Centre","ror":"https://ror.org/0066jxm83","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210094512"]},{"id":"https://openalex.org/I4210163178","display_name":"Alfred Health","ror":"https://ror.org/04scfb908","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Paul U Cameron","raw_affiliation_strings":["Albion Street Centre, Sydney, Australia","Department of Medicine, Monash University, Melbourne, Australia","Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia","Medicine Alfred Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albion Street Centre, Sydney, Australia","institution_ids":["https://openalex.org/I4210094512"]},{"raw_affiliation_string":"Department of Medicine, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia","institution_ids":["https://openalex.org/I2801993434"]},{"raw_affiliation_string":"Medicine Alfred Hospital","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109957427","display_name":"DF Purcell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Damian J Purcell","raw_affiliation_strings":["Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia","University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088309165","display_name":"John James Zaunders","orcid":"https://orcid.org/0000-0002-5912-5989","observed_orcids":["https://orcid.org/0000-0002-5912-5989"]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John J Zaunders","raw_affiliation_strings":["Centre for Immunology, St. Vincent's Hospital, Sydney, Australia","St. Vincent's Hospital Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St. Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"St. Vincent's Hospital Sydney","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068183703","display_name":"Pat Grey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Pat Grey","raw_affiliation_strings":["National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","University Of New south Wales"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"University Of New south Wales","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031995978","display_name":"Mark Theo Bloch","orcid":"https://orcid.org/0000-0002-1143-5013","observed_orcids":["https://orcid.org/0000-0002-1143-5013"]},"institutions":[{"id":"https://openalex.org/I4405267128","display_name":"Holdsworth House Medical Practice","ror":"https://ror.org/01ae50z68","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4405267128"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark Bloch","raw_affiliation_strings":["Holdsworth House Medical Practice, Sydney Australia","Holdsworth House Medical Practice (New South Wales)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holdsworth House Medical Practice, Sydney Australia","institution_ids":["https://openalex.org/I4405267128"]},{"raw_affiliation_string":"Holdsworth House Medical Practice (New South Wales)","institution_ids":["https://openalex.org/I4405267128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018068497","display_name":"Don\u00a0E. Smith","orcid":"https://orcid.org/0000-0002-1308-4595","observed_orcids":["https://orcid.org/0000-0002-1308-4595"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I4210094512","display_name":"Albion Centre","ror":"https://ror.org/0066jxm83","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210094512"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Don Smith","raw_affiliation_strings":["Albion Street Centre, Sydney, Australia","Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia","Albion Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albion Street Centre, Sydney, Australia","institution_ids":["https://openalex.org/I4210094512"]},{"raw_affiliation_string":"Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia","institution_ids":["https://openalex.org/I2801993434"]},{"raw_affiliation_string":"Albion Centre","institution_ids":["https://openalex.org/I4210094512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834622","display_name":"David A. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David A Cooper","raw_affiliation_strings":["National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","St. Vincent's Hospital Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"St. Vincent's Hospital Sydney","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068421356","display_name":"Anthony Dominic Kelleher","orcid":"https://orcid.org/0000-0002-0009-3337","observed_orcids":["https://orcid.org/0000-0002-0009-3337"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony D Kelleher","raw_affiliation_strings":["Centre for Immunology, St. Vincent's Hospital, Sydney, Australia","National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","St. Vincent's Hospital Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St. Vincent's Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"St. Vincent's Hospital Sydney","institution_ids":["https://openalex.org/I4210087284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018068497","https://openalex.org/A5055398640","https://openalex.org/A5062645957"],"corresponding_institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I4210094512","https://openalex.org/I4210163178","https://openalex.org/I56590836"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"2","first_page":"140","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-hiv-1-infection","display_name":"acute HIV-1 infection","score":0.9010000228881836},{"id":"https://openalex.org/keywords/primary-hiv-1-infection","display_name":"primary HIV-1 infection","score":0.878000020980835},{"id":"https://openalex.org/keywords/structured-treatment-interruption","display_name":"structured treatment interruption","score":0.984000027179718},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.8040000200271606},{"id":"https://openalex.org/keywords/viral-rebound","display_name":"viral rebound","score":0.8130000233650208},{"id":"https://openalex.org/keywords/latent-hiv-1-reservoir","display_name":"latent HIV-1 reservoir","score":0.6549999713897705},{"id":"https://openalex.org/keywords/resting-memory-cd4-t-cells","display_name":"resting memory CD4+ T cells","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.8333737850189209},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6425702571868896},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5818593502044678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5752615928649902},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5398054122924805},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5086249113082886},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.45597848296165466},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.44142961502075195},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.41292843222618103},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41261035203933716},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.33897489309310913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27714061737060547},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24226638674736023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08701854944229126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.056497395038604736}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D028761","descriptor_name":"Withholding Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/qai.0b013e31815dbf7f","doi":"https://doi.org/10.1097/qai.0b013e31815dbf7f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qai.0b013e31815dbf7f","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},{"id":"pmid:18300365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18300365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes (1999)","raw_type":"Journal Article"},{"id":"pmid:18580274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18580274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cornea","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W67206657","https://openalex.org/W1497170016","https://openalex.org/W1517131856","https://openalex.org/W1690499972","https://openalex.org/W1815763197","https://openalex.org/W1977485148","https://openalex.org/W1978406880","https://openalex.org/W1981117511","https://openalex.org/W1982276846","https://openalex.org/W1992891916","https://openalex.org/W1995597879","https://openalex.org/W1997307318","https://openalex.org/W2000564337","https://openalex.org/W2005319454","https://openalex.org/W2011630381","https://openalex.org/W2019526147","https://openalex.org/W2031037912","https://openalex.org/W2037343680","https://openalex.org/W2039299595","https://openalex.org/W2046603221","https://openalex.org/W2048446675","https://openalex.org/W2051269276","https://openalex.org/W2056833651","https://openalex.org/W2060829964","https://openalex.org/W2061815395","https://openalex.org/W2071486968","https://openalex.org/W2072984723","https://openalex.org/W2092983430","https://openalex.org/W2101843339","https://openalex.org/W2102145741","https://openalex.org/W2103105658","https://openalex.org/W2106336618","https://openalex.org/W2115269067","https://openalex.org/W2117962018","https://openalex.org/W2120246948","https://openalex.org/W2125389159","https://openalex.org/W2126633107","https://openalex.org/W2132618997","https://openalex.org/W2133866490","https://openalex.org/W2137671068","https://openalex.org/W2141675394","https://openalex.org/W2143135600","https://openalex.org/W2143437140","https://openalex.org/W2150484278","https://openalex.org/W2157418548","https://openalex.org/W2159689940","https://openalex.org/W2302345785","https://openalex.org/W2318289184","https://openalex.org/W2319657764","https://openalex.org/W2774292278","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2064989937","https://openalex.org/W1970132486","https://openalex.org/W2417922239","https://openalex.org/W2120246948","https://openalex.org/W7071551996","https://openalex.org/W2168795464","https://openalex.org/W3008667274","https://openalex.org/W4286512099","https://openalex.org/W2035579197","https://openalex.org/W2049600508"],"abstract_inverted_index":{"BACKGROUND:":[0],"Latently":[1],"infected":[2],"resting":[3],"memory":[4],"CD4":[5],"T":[6],"cells":[7],"are":[8],"thought":[9],"to":[10,17,42,62],"be":[11],"the":[12,34,37,126,203],"major":[13],"reservoir":[14],"that":[15],"contributes":[16],"rebound":[18,210],"viremia":[19],"after":[20,125,198,211],"cessation":[21],"of":[22,36,45,78,128,174,200],"antiretrovirals":[23],"(ARVs).":[24],"Commencing":[25],"ARVs":[26,64,129,175],"during":[27,48],"primary":[28],"HIV-1":[29,79,98,101,105,121,161,163,166,170,181,193],"infection":[30],"(PHI)":[31],"may":[32],"limit":[33],"size":[35],"latent":[38],"pool":[39],"and":[40,103,156,165],"lead":[41],"improved":[43],"control":[44],"viral":[46,209],"replication":[47],"structured":[49],"treatment":[50,212],"interruption":[51,213],"(STI).":[52],"METHODS:":[53],"Individuals":[54],"with":[55,65,140,179,208],"PHI":[56],"(n":[57,94,136,143],"=":[58,95,137,144,147,187,190],"59)":[59],"were":[60,109,150],"randomized":[61],"receive":[63],"or":[66],"without":[67],"hydroxyurea.":[68],"After":[69],"STI,":[70],"a":[71,89,112],"good":[72,134,155],"response":[73],"was":[74,130,176,202],"defined":[75],"as":[76],"maintenance":[77],"RNA":[80,108,122,182,194],"<5000":[81],"copies/mL":[82],"for":[83],"24":[84],"weeks":[85,124,197],"off":[86],"therapy.":[87],"In":[88],"detailed":[90],"prospective":[91],"virologic":[92,205],"substudy":[93],"19),":[96],"integrated":[97,160],"DNA,":[99,102,162,164],"total":[100],"cell-associated":[104],"unspliced":[106],"(US)":[107],"quantified":[110],"using":[111],"real-time":[113],"polymerase":[114],"chain":[115],"reaction":[116],"assay.":[117],"RESULTS:":[118],"The":[119],"plasma":[120,180],"12":[123,185,196],"initiation":[127,173,199],"significantly":[131],"lower":[132],"in":[133,159,214],"responders":[135,142,158],"7)":[138],"compared":[139],"poor":[141,157],"12)":[145],"(P":[146,186],"0.005).":[148],"There":[149],"no":[151],"significant":[152],"differences":[153],"between":[154],"US":[167],"RNA.":[168],"Integrated":[169],"DNA":[171],"before":[172],"strongly":[177],"correlated":[178],"at":[183],"week":[184],"0.006,":[188],"r":[189],"0.81).":[191],"CONCLUSION:":[192],"measured":[195],"ARV":[201],"only":[204],"variable":[206],"associated":[207],"PHI.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
