{"id":"https://openalex.org/W1967960010","doi":"https://doi.org/10.1248/bpb.21.174","title":"Effects of Fatty Acids on Serum Binding between Furosemide and Valproic Acid.","display_name":"Effects of Fatty Acids on Serum Binding between Furosemide and Valproic Acid.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1967960010","doi":"https://doi.org/10.1248/bpb.21.174","mag":"1967960010","pmid":"https://pubmed.ncbi.nlm.nih.gov/9514615"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.21.174","doi":"https://doi.org/10.1248/bpb.21.174","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.21.174","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/2/21_2_174/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/2/21_2_174/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Norito TAKAMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norito TAKAMURA","raw_affiliation_strings":["Department of Pharmacy, Miyazaki Medical College Hospital, Japan","Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Miyazaki Medical College Hospital, Japan","institution_ids":[]},{"raw_affiliation_string":"Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079652012","display_name":"Shinya Shinozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya SHINOZAWA","raw_affiliation_strings":["University of miyazaki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of miyazaki","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063029271","display_name":"Toru Maruyama","orcid":"https://orcid.org/0000-0002-1729-7766","observed_orcids":["https://orcid.org/0000-0002-1729-7766"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru MARUYAMA","raw_affiliation_strings":["Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113546371","display_name":"Ayaka Suenaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayaka SUENAGA","raw_affiliation_strings":["Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007915406","display_name":"Masaki OTAGIRI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki OTAGIRI","raw_affiliation_strings":["Kumamoto University, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0969,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.32487291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"2","first_page":"174","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fatty-acids","display_name":"fatty acids","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oleate","display_name":"oleate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drug-binding","display_name":"drug binding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.6890000104904175},{"id":"https://openalex.org/keywords/displacement","display_name":"displacement","score":0.3190000057220459},{"id":"https://openalex.org/keywords/ultrafiltration","display_name":"ultrafiltration","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.9279004335403442},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.8935215473175049},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7606353759765625},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.6301218271255493},{"id":"https://openalex.org/C2781233306","wikidata":"https://www.wikidata.org/wiki/Q5500236","display_name":"Free fraction","level":3,"score":0.5278525352478027},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4255248010158539},{"id":"https://openalex.org/C50817676","wikidata":"https://www.wikidata.org/wiki/Q7880534","display_name":"Ultrafiltration (renal)","level":2,"score":0.42284417152404785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3405747413635254},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.22603482007980347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0757480263710022},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06129756569862366},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.21.174","doi":"https://doi.org/10.1248/bpb.21.174","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.21.174","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/2/21_2_174/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:9514615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9514615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.21.174","doi":"https://doi.org/10.1248/bpb.21.174","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.21.174","pdf_url":"https://www.jstage.jst.go.jp/article/bpb1993/21/2/21_2_174/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967960010.pdf","grobid_xml":"https://content.openalex.org/works/W1967960010.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W1508154903"],"related_works":["https://openalex.org/W2074265193","https://openalex.org/W2083467366","https://openalex.org/W2020076084","https://openalex.org/W1954882272","https://openalex.org/W2061186878","https://openalex.org/W2411679069","https://openalex.org/W2042616778","https://openalex.org/W2068636160","https://openalex.org/W2320292994","https://openalex.org/W1987423966"],"abstract_inverted_index":{"The":[0,29,64],"effects":[1],"of":[2,32,40,68,75,93,101,107,126,143],"fatty":[3,79,86,114,127,157],"acids,":[4],"including":[5],"oleate,":[6],"on":[7,59,132],"the":[8,38,73,90,99,105,120,123,133,138,141],"interaction":[9],"between":[10],"furosemide":[11,33,48,69,94,108,134,145],"and":[12,49,129],"valproic":[13,41,50,102,130,147],"acid":[14,51,80,128,131,148],"in":[15,37,89],"sera":[16],"at":[17],"respective":[18],"serum":[19,61,65,111],"therapeutic":[20],"concentration":[21],"levels":[22],"were":[23],"investigated":[24],"using":[25],"an":[26],"ultrafiltration":[27],"technique.":[28],"free":[30,66],"fraction":[31,67,92],"was":[34,70,95,149],"significantly":[35],"increased":[36,71,97],"presence":[39,74],"acid.":[42,103],"Mutual":[43],"displacement":[44,142],"experiments":[45],"indicated":[46],"that":[47,155],"share":[52],"a":[53,113],"common":[54],"high":[55],"affinity":[56],"binding":[57,100,109],"site":[58],"human":[60],"albumin":[62],"(HSA).":[63],"by":[72,98,146],"six":[76],"or":[77],"more":[78],"molecules":[81],"per":[82],"HSA":[83],"molecule.":[84],"This":[85],"acid-induced":[87],"increase":[88],"unbound":[91],"further":[96],"However,":[104],"inhibition":[106],"to":[110,135,151],"for":[112,140,156],"acid-valproic":[115],"acid-furosemide":[116],"system":[117],"is":[118],"nearly":[119],"same":[121],"as":[122],"additive":[124],"effect":[125],"serum.":[136],"Thus,":[137],"mechanism":[139],"HSA-bound":[144],"concluded":[150],"be":[152],"different":[153],"from":[154],"acid-catalyzed":[158],"displacement.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}