{"id":"https://openalex.org/W1967945909","doi":"https://doi.org/10.1161/01.cir.85.4.1440","title":"Intermittent ST depression and mortality after myocardial infarction.","display_name":"Intermittent ST depression and mortality after myocardial infarction.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W1967945909","doi":"https://doi.org/10.1161/01.cir.85.4.1440","mag":"1967945909","pmid":"https://pubmed.ncbi.nlm.nih.gov/1555284"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.85.4.1440","doi":"https://doi.org/10.1161/01.cir.85.4.1440","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.85.4.1440","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002210834","display_name":"William Ruberman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Ruberman","raw_affiliation_strings":["Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412521","display_name":"Richard S. Crow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Crow","raw_affiliation_strings":["Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110333840","display_name":"Carl R. Rosenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C R Rosenberg","raw_affiliation_strings":["Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112582157","display_name":"Pentti M. Rautaharju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P M Rautaharju","raw_affiliation_strings":["Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054222139","display_name":"Roy E. Shore","orcid":"https://orcid.org/0000-0002-6842-2248","observed_orcids":["https://orcid.org/0000-0002-6842-2248"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Shore","raw_affiliation_strings":["Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113527877","display_name":"Bernard S. Pasternack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B S Pasternack","raw_affiliation_strings":["Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, New York University School of Medicine, NY 10010-2598","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":5.3011,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.95679825,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"85","issue":"4","first_page":"1440","last_page":"1446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7720000147819519},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anti-ischemic-effect","display_name":"anti-ischemic effect","score":0.8309999704360962},{"id":"https://openalex.org/keywords/angina","display_name":"angina pectoris","score":0.6259999871253967},{"id":"https://openalex.org/keywords/24-hour-ecg-monitoring","display_name":"24-hour ECG monitoring","score":0.7870000004768372},{"id":"https://openalex.org/keywords/post-infarction-survival","display_name":"post-infarction survival","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9701601266860962},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6990842819213867},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6938539147377014},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.6611357927322388},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6259877681732178},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5755651593208313},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.5693404078483582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5613824725151062},{"id":"https://openalex.org/C2780395512","wikidata":"https://www.wikidata.org/wiki/Q3965303","display_name":"ST depression","level":4,"score":0.5441606044769287},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5159333348274231},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44771236181259155},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015716","descriptor_name":"Electrocardiography, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.85.4.1440","doi":"https://doi.org/10.1161/01.cir.85.4.1440","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.85.4.1440","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:1555284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1555284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Clinical Trial"},{"id":"mag:3145770876","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.85.4.1555284","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2956864766","display_name":"INTERMITTENT ST DEPRESSION AND PROGNOSIS AFTER MI","funder_award_id":"R01HL039641","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G539439037","display_name":null,"funder_award_id":"HL39641","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1971878930","https://openalex.org/W1972740751","https://openalex.org/W1974238026","https://openalex.org/W1977054557","https://openalex.org/W2006389689","https://openalex.org/W2008485226","https://openalex.org/W2009478499","https://openalex.org/W2044727600","https://openalex.org/W2084413241","https://openalex.org/W2088982738","https://openalex.org/W2109169719","https://openalex.org/W2114938969","https://openalex.org/W2314745108","https://openalex.org/W2337337657","https://openalex.org/W4205376562","https://openalex.org/W4244341064","https://openalex.org/W4245030575","https://openalex.org/W4248605684"],"related_works":["https://openalex.org/W2113795238","https://openalex.org/W2016533959","https://openalex.org/W2046911704","https://openalex.org/W2736900982","https://openalex.org/W2020824549","https://openalex.org/W1971024015","https://openalex.org/W2032863695","https://openalex.org/W1980902536","https://openalex.org/W2006694478","https://openalex.org/W3142865402"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"conducted":[2,64],"a":[3,44,111,118,167,201,237],"case-control":[4],"analysis":[5,38],"to":[6,11,71,152,204,243],"determine":[7,244],"the":[8,22,56,163,225],"contribution":[9,203],"made":[10],"mortality":[12,205],"by":[13,36,49,80,166,233],"intermittent":[14],"ST":[15,47,60,76],"depression":[16],"(STD)":[17],"among":[18,206],"patients":[19,135],"enrolled":[20],"in":[21,46,133,139,162,171,180,196,224],"already":[23],"completed":[24],"Beta":[25],"Blocker":[26],"Heart":[27],"Attack":[28],"Trial.":[29],"METHODS":[30],"AND":[31],"RESULTS:":[32],"STD":[33,116,177,187,214,248],"was":[34,130,150,160],"determined":[35],"computer":[37],"of":[39,59,61,86,122,144,158,169,176,186,222,247],"24-hour":[40,216],"ECG":[41],"tapes":[42],"as":[43],"change":[45],"level":[48],"+/-":[50],"0.1":[51],"mV":[52],"or":[53,69,220],"more":[54],"from":[55,212],"median":[57],"value":[58],"all":[62],"normally":[63],"complexes":[65],"for":[66,98],"greater":[67,183],"than":[68,184],"equal":[70],"1":[72],"minute.":[73],"All":[74],"computer-detected":[75],"events":[77],"were":[78,93],"verified":[79],"trained":[81],"readers.":[82],"To":[83],"estimate":[84],"risk":[85,120,159],"dying":[87],"associated":[88],"with":[89,95,173,182],"STD,":[90],"261":[91],"deaths":[92],"compared":[94],"controls":[96],"matched":[97],"age,":[99],"sex,":[100],"drug":[101],"status,":[102],"and":[103,136,178],"time":[104],"elapsed":[105],"since":[106],"acute":[107],"myocardial":[108],"infarction.":[109],"In":[110],"model":[112],"including":[113],"relevant":[114],"covariates,":[115],"had":[117],"relative":[119],"(RR)":[121],"1.73":[123],"(95%":[124],"confidence":[125],"interval,":[126],"1.09-2.73).":[127],"The":[128,194,218],"RR":[129,168],"2.56":[131],"(1.39-4.71)":[132],"untreated":[134,207],"0.98":[137],"(0.48-2.00)":[138],"propranolol-treated":[140],"patients.":[141],"A":[142,156],"history":[143],"angina,":[145],"although":[146],"not":[147],"independently":[148],"significant,":[149],"found":[151],"enhance":[153],"these":[154],"RRs.":[155],"gradient":[157],"shown":[161],"placebo":[164],"group":[165,227],"1.91":[170],"those":[172,181],"1-30":[174],"minutes":[175],"4.33":[179],"30":[185],"(p":[188],"=":[189],"0.001,":[190],"trend":[191],"test).":[192],"CONCLUSIONS:":[193],"findings":[195],"this":[197],"large":[198],"study":[199],"show":[200],"significant":[202],"early":[208],"post-myocardial":[209],"infarction":[210],"survivors":[211],"transient":[213],"on":[215,240],"monitoring.":[217],"absence":[219],"reduction":[221,246],"effect":[223,239],"treated":[226],"also":[228],"suggests":[229],"an":[230],"anti-ischemic":[231],"mechanism":[232],"which":[234],"propranolol":[235],"exerts":[236],"protective":[238],"mortality.":[241],"Trials":[242],"whether":[245],"improves":[249],"survival":[250],"would":[251],"be":[252],"warranted.":[253]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}