{"id":"https://openalex.org/W1967897108","doi":"https://doi.org/10.1016/j.jmb.2003.09.071","title":"An Alternative Route for the Folding of Large RNAs: Apparent Two-state Folding by a Group II Intron Ribozyme","display_name":"An Alternative Route for the Folding of Large RNAs: Apparent Two-state Folding by a Group II Intron Ribozyme","publication_year":2003,"publication_date":"2003-11-20","ids":{"openalex":"https://openalex.org/W1967897108","doi":"https://doi.org/10.1016/j.jmb.2003.09.071","mag":"1967897108","pmid":"https://pubmed.ncbi.nlm.nih.gov/14636593"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2003.09.071","doi":"https://doi.org/10.1016/j.jmb.2003.09.071","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2003.09.071","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090215028","display_name":"Linhui Julie Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linhui Julie Su","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010967667","display_name":"Michael D. Brenowitz","orcid":"https://orcid.org/0000-0003-0048-1716","observed_orcids":["https://orcid.org/0000-0003-0048-1716"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Brenowitz","raw_affiliation_strings":["Department of Biochemistry, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007909912","display_name":"Anna Marie Pyle","orcid":"https://orcid.org/0000-0001-9045-8872","observed_orcids":["https://orcid.org/0000-0001-9045-8872"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna Marie Pyle","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA","Howard Hughes Medical Institute; Columbia University, New York, NY 10032, USA","Columbia University, New York, NY 10032, USA","Howard Hughes Medical Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Howard Hughes Medical Institute; Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007909912"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.5088,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.80000287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"334","issue":"4","first_page":"639","last_page":"652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/two-state-folding","display_name":"two-state folding","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cooperative-folding","display_name":"cooperative folding","score":0.8339999914169312},{"id":"https://openalex.org/keywords/magnesium-dependence","display_name":"magnesium dependence","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hydroxyl-radical-footprinting","display_name":"hydroxyl radical footprinting","score":0.859000027179718},{"id":"https://openalex.org/keywords/urea-denaturation","display_name":"urea denaturation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/folding-intermediates","display_name":"folding intermediates","score":0.8130000233650208},{"id":"https://openalex.org/keywords/folding-energy-landscape","display_name":"folding energy landscape","score":0.8730000257492065},{"id":"https://openalex.org/keywords/self-splicing-ribozymes","display_name":"self-splicing ribozymes","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.9260397553443909},{"id":"https://openalex.org/C66144319","wikidata":"https://www.wikidata.org/wiki/Q7907583","display_name":"VS ribozyme","level":5,"score":0.5948197245597839},{"id":"https://openalex.org/C30951146","wikidata":"https://www.wikidata.org/wiki/Q6745754","display_name":"Mammalian CPEB3 ribozyme","level":5,"score":0.5880877375602722},{"id":"https://openalex.org/C107745601","wikidata":"https://www.wikidata.org/wiki/Q3934265","display_name":"Hairpin ribozyme","level":5,"score":0.5729983448982239},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5677723288536072},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5626137256622314},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.527809739112854},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.5136286616325378},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.4801556468009949},{"id":"https://openalex.org/C64962909","wikidata":"https://www.wikidata.org/wiki/Q5611160","display_name":"Group II intron","level":5,"score":0.4753391742706299},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4751952886581421},{"id":"https://openalex.org/C75599170","wikidata":"https://www.wikidata.org/wiki/Q898483","display_name":"Protein tertiary structure","level":2,"score":0.45149677991867065},{"id":"https://openalex.org/C19472624","wikidata":"https://www.wikidata.org/wiki/Q583851","display_name":"Native state","level":2,"score":0.43860742449760437},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4383249580860138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4362275004386902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38160860538482666},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3063803017139435},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27359315752983093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07584226131439209},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012331","descriptor_name":"RNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012331","descriptor_name":"RNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012331","descriptor_name":"RNA, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jmb.2003.09.071","doi":"https://doi.org/10.1016/j.jmb.2003.09.071","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2003.09.071","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:14636593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14636593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3179889755","display_name":"Structure and Function of Group II Intron Ribozyme","funder_award_id":"R01GM050313","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3522480728","display_name":"STRUCTURAL MOTIFS IN MEMBRANE PROTEINS","funder_award_id":"P01GM054160","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6075081993","display_name":"ANALYTICAL ULTRACENTRIFUGE","funder_award_id":"S10RR012848","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7170510958","display_name":"STRUCTURAL BIOLOGY OF RNA FOLDING","funder_award_id":"R01GM052348","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7981333197","display_name":"Training Program in Molecular Biophysics","funder_award_id":"T32GM008281","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W111310851","https://openalex.org/W597159688","https://openalex.org/W1227091703","https://openalex.org/W1483332544","https://openalex.org/W1486309167","https://openalex.org/W1513508587","https://openalex.org/W1520397060","https://openalex.org/W1530704185","https://openalex.org/W1554307500","https://openalex.org/W1573839013","https://openalex.org/W1573986638","https://openalex.org/W1586999333","https://openalex.org/W1657937336","https://openalex.org/W1663593274","https://openalex.org/W1889077695","https://openalex.org/W1905425287","https://openalex.org/W1965423166","https://openalex.org/W1968455698","https://openalex.org/W1970040635","https://openalex.org/W1975317507","https://openalex.org/W1985368446","https://openalex.org/W1987674601","https://openalex.org/W1991210664","https://openalex.org/W1992621299","https://openalex.org/W1993619986","https://openalex.org/W1995427534","https://openalex.org/W1995552039","https://openalex.org/W2000934718","https://openalex.org/W2009632874","https://openalex.org/W2010245041","https://openalex.org/W2017076970","https://openalex.org/W2020563037","https://openalex.org/W2022289189","https://openalex.org/W2027250972","https://openalex.org/W2029927731","https://openalex.org/W2036116609","https://openalex.org/W2042441128","https://openalex.org/W2044020586","https://openalex.org/W2044050650","https://openalex.org/W2048409037","https://openalex.org/W2048446724","https://openalex.org/W2049681307","https://openalex.org/W2057850636","https://openalex.org/W2065616187","https://openalex.org/W2072656934","https://openalex.org/W2078165294","https://openalex.org/W2080251448","https://openalex.org/W2082123764","https://openalex.org/W2083313193","https://openalex.org/W2084408967","https://openalex.org/W2084841438","https://openalex.org/W2086253147","https://openalex.org/W2090375359","https://openalex.org/W2091180070","https://openalex.org/W2100141723","https://openalex.org/W2105568344","https://openalex.org/W2107962891","https://openalex.org/W2117747873","https://openalex.org/W2141232701","https://openalex.org/W2145228646","https://openalex.org/W2164552624","https://openalex.org/W2176375858","https://openalex.org/W2212911419","https://openalex.org/W2215282776","https://openalex.org/W2217579908","https://openalex.org/W4243831105","https://openalex.org/W4321429423"],"related_works":["https://openalex.org/W2096955927","https://openalex.org/W1978568219","https://openalex.org/W2001755740","https://openalex.org/W2097070674","https://openalex.org/W2084408967","https://openalex.org/W183459555","https://openalex.org/W2022289189","https://openalex.org/W2075080060","https://openalex.org/W2095975517","https://openalex.org/W7100421653"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
