{"id":"https://openalex.org/W1967851981","doi":"https://doi.org/10.1016/j.clpt.2004.12.068","title":"Effects of infant formula, cow milk and human milk on drug metabolizing enzymes","display_name":"Effects of infant formula, cow milk and human milk on drug metabolizing enzymes","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W1967851981","doi":"https://doi.org/10.1016/j.clpt.2004.12.068","mag":"1967851981"},"language":"en","primary_location":{"id":"doi:10.1016/j.clpt.2004.12.068","doi":"https://doi.org/10.1016/j.clpt.2004.12.068","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clpt.2004.12.068","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102913645","display_name":"Hui Xu","orcid":"https://orcid.org/0000-0002-8459-7654","observed_orcids":["https://orcid.org/0000-0002-8459-7654"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"H XU","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052880274","display_name":"Ratheishan Rajesan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"R RAJESAN","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R KIM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"R KIM","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023246864","display_name":"Steven A. Kliewer","orcid":"https://orcid.org/0000-0001-5161-641X","observed_orcids":["https://orcid.org/0000-0001-5161-641X"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"S KLIEWER","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015168279","display_name":"Bo L\u00f6nnerdal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"B LONNERDAL","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P HARPER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"P HARPER","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M HO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"M HO","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J YUN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"J YUN","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111908146","display_name":"J.R. Hutson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"J HUTSON","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033710795","display_name":"Shinya Ito","orcid":"https://orcid.org/0000-0002-4498-3075","observed_orcids":["https://orcid.org/0000-0002-4498-3075"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"S ITO","raw_affiliation_strings":["Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Sick Children, Vanderbilt University School of Medicine, University of Texas Southwestern Medical Center, University of California, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I2801317318","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09347079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"2","first_page":"P46","last_page":"P46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infant-formula","display_name":"infant formula","score":0.996999979019165},{"id":"https://openalex.org/keywords/cow-s-milk","display_name":"cow's milk","score":0.9279999732971191},{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyp1a","display_name":"CYP1A","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/caffeine-metabolism","display_name":"caffeine metabolism","score":0.6119999885559082},{"id":"https://openalex.org/keywords/neonatal-apnea","display_name":"neonatal apnea","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dibenz-a-h-anthracene","display_name":"dibenzo[a,h]anthracene","score":0.9269999861717224},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.9130560159683228},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.6997421383857727},{"id":"https://openalex.org/C2779150110","wikidata":"https://www.wikidata.org/wiki/Q2287198","display_name":"Infant formula","level":2,"score":0.6980879306793213},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.5552753210067749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5371077656745911},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47291192412376404},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.4727039337158203},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46886566281318665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45738333463668823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43051838874816895},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.3247653543949127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27500098943710327},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26077499985694885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23689723014831543},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.2249419093132019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21469464898109436},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07074037194252014},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06706807017326355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.clpt.2004.12.068","doi":"https://doi.org/10.1016/j.clpt.2004.12.068","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clpt.2004.12.068","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1533813129","https://openalex.org/W2157450756","https://openalex.org/W7132979001","https://openalex.org/W7133040645","https://openalex.org/W2018358374","https://openalex.org/W2068240263","https://openalex.org/W2071401083","https://openalex.org/W2165097706","https://openalex.org/W2094020778","https://openalex.org/W2295270012"],"abstract_inverted_index":{"Background":[0],"Caffeine,":[1],"used":[2],"for":[3,105],"treating":[4],"neonatal":[5],"apnea,":[6],"is":[7,19],"eliminated":[8],"3-fold":[9],"slower":[10],"in":[11,15],"breastfed":[12],"infants":[13],"than":[14],"formula-fed":[16],"infants.":[17],"Caffeine":[18],"metabolized":[20],"by":[21,31,83,92,116,123,129,133,149,188],"cytochrome":[22],"P450":[23],"(CYP)":[24],"1A":[25],"and":[26,36,71,87,94,111,118,139,168,177,213],"CYP3A4,":[27],"which":[28],"are":[29],"regulated":[30],"aryl":[32],"hydrocarbon":[33],"receptor":[34,39,100],"(AhR)":[35],"pregnane":[37],"X":[38],"(PXR)":[40],"respectively.":[41],"Here":[42],"we":[43],"hypothesized":[44],"that":[45,206],"formula":[46,70,117,130,159,167,198,212],"but":[47,121,160,199],"not":[48,122,161,184,200],"human":[49,124,140,162,169,201,214],"milk":[50,61,73,79,120,141,163,170,189,202,215],"induces":[51,207],"CYP1A":[52,109,208],"and/or":[53],"CYP3A4":[54,175,217],"via":[55],"their":[56,106],"regulatory":[57],"pathways.":[58],"Methods":[59],"Human":[60],"samples":[62,80],"from":[63],"healthy":[64],"lactating":[65],"women":[66],"were":[67,74,90,103,114],"collected.":[68],"Infant":[69,197],"cow":[72,119],"purchased.":[75],"Lipid":[76],"fraction":[77,157],"of":[78,135,158,174,181],"was":[81,131],"obtained":[82],"organic":[84],"extraction.":[85],"mRNA":[86,176],"protein":[88],"expression":[89,110],"measured":[91],"RT-PCR":[93],"western":[95],"blotting.":[96],"Reporter":[97],"plasmids":[98],"containing":[99],"response":[101],"elements":[102],"tested":[104],"activation.":[107],"Results":[108],"AhR":[112,127,147,152,204],"activity":[113],"induced":[115],"milk.":[125],"The":[126],"activation":[128,148,187],"abolished":[132],"co-treatment":[134],"Ah":[136],"antagonist.":[137],"Formula":[138],"also":[142],"had":[143],"differential":[144],"effects":[145],"on":[146],"dibenz[a,h]anthracene,":[150],"an":[151],"agonist.":[153],"In":[154],"addition,":[155],"lipid":[156],"activated":[164],"AhR.":[165],"Both":[166,210],"showed":[171],"mild":[172],"induction":[173],"PXR.":[178],"However,":[179],"co-transfection":[180],"hPXR":[182],"did":[183],"increase":[185],"PXR":[186],"treatments,":[190],"suggesting":[191],"a":[192],"non":[193,219],"PXR-mediated":[194,220],"pathway.":[195,221],"Conclusion":[196],"contains":[203],"agonist(s)":[205],"expression.":[209],"infant":[211],"induce":[216],"through":[218],"Clinical":[222],"Pharmacology":[223],"&":[224],"Therapeutics":[225],"(2005)":[226],"77,":[227],"P46\u2013P46;":[228],"doi:":[229],"10.1016/j.clpt.2004.12.068":[230]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}