{"id":"https://openalex.org/W1967795278","doi":"https://doi.org/10.1038/sj.bjc.6603525","title":"ASPP: a new family of oncogenes and tumour suppressor genes","display_name":"ASPP: a new family of oncogenes and tumour suppressor genes","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1967795278","doi":"https://doi.org/10.1038/sj.bjc.6603525","mag":"1967795278","pmid":"https://pubmed.ncbi.nlm.nih.gov/17211478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2359998"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6603525","doi":"https://doi.org/10.1038/sj.bjc.6603525","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603525","pdf_url":"https://www.nature.com/articles/6603525.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6603525.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073409178","display_name":"Angela Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Sullivan","raw_affiliation_strings":["Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London, W1W 7BS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London, W1W 7BS, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100719902","display_name":"Xin L\u00fc","orcid":"https://orcid.org/0000-0002-6587-1152","observed_orcids":["https://orcid.org/0000-0002-6587-1152"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"X Lu","raw_affiliation_strings":["Ludwig Institute for Cancer Research , University College London , 91 Riding House Street , London W1W 7BS , UK","Ludwig Institute for Cancer Research, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research , University College London , 91 Riding House Street , London W1W 7BS , UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100719902"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.7589,"has_fulltext":true,"cited_by_count":219,"citation_normalized_percentile":{"value":0.84666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"96","issue":"2","first_page":"196","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspp1","display_name":"ASPP1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/aspp2","display_name":"ASPP2","score":1.0},{"id":"https://openalex.org/keywords/iaspp","display_name":"iASPP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.675000011920929},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.7580000162124634},{"id":"https://openalex.org/keywords/p73","display_name":"p73","score":1.0},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/rela-p65","display_name":"RelA/p65","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7027237415313721},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6858187913894653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.659704327583313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6577243804931641},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5829928517341614},{"id":"https://openalex.org/C149150037","wikidata":"https://www.wikidata.org/wiki/Q554446","display_name":"Bcl-2 family","level":4,"score":0.543738603591919},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5430542826652527},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5340626835823059},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5034200549125671},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4873972535133362},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.4866081476211548},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.48142334818840027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4693853557109833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44569918513298035},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4278285503387451},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.37125861644744873},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.19134345650672913},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17406821250915527}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/sj.bjc.6603525","doi":"https://doi.org/10.1038/sj.bjc.6603525","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603525","pdf_url":"https://www.nature.com/articles/6603525.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2359998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2359998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:17211478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17211478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.281.5143","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.5143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a8/2a/Br_J_Cancer_2007_Jan_29_96(2)_196-200.tar.gz","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1478554","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1478554/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BRITISH JOURNAL OF CANCER , 96 (2) pp. 196-200. (2007)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6603525","doi":"https://doi.org/10.1038/sj.bjc.6603525","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603525","pdf_url":"https://www.nature.com/articles/6603525.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967795278.pdf","grobid_xml":"https://content.openalex.org/works/W1967795278.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1490290866","https://openalex.org/W1593602781","https://openalex.org/W1604166471","https://openalex.org/W1772676198","https://openalex.org/W1968749685","https://openalex.org/W1971274526","https://openalex.org/W1973574504","https://openalex.org/W1977706798","https://openalex.org/W1985208675","https://openalex.org/W1985634754","https://openalex.org/W1988106286","https://openalex.org/W2010370535","https://openalex.org/W2010562722","https://openalex.org/W2017464762","https://openalex.org/W2020625331","https://openalex.org/W2021064508","https://openalex.org/W2022756191","https://openalex.org/W2027791090","https://openalex.org/W2028553570","https://openalex.org/W2033872434","https://openalex.org/W2036981062","https://openalex.org/W2042798121","https://openalex.org/W2049466717","https://openalex.org/W2057623727","https://openalex.org/W2078308376","https://openalex.org/W2084234014","https://openalex.org/W2087732778","https://openalex.org/W2089623038","https://openalex.org/W2093716349","https://openalex.org/W2108630708","https://openalex.org/W2114201316","https://openalex.org/W2118508998","https://openalex.org/W2130503316","https://openalex.org/W2132479515","https://openalex.org/W2145747877","https://openalex.org/W2146987863","https://openalex.org/W2151807575","https://openalex.org/W2152733195","https://openalex.org/W2157359868","https://openalex.org/W2164920366"],"related_works":["https://openalex.org/W7100074947","https://openalex.org/W3031482817","https://openalex.org/W1977231478","https://openalex.org/W2001279251","https://openalex.org/W2087732778","https://openalex.org/W2361469756","https://openalex.org/W2069552272","https://openalex.org/W2380146262","https://openalex.org/W2118508998","https://openalex.org/W1160907233"],"abstract_inverted_index":{"The":[0,87],"apoptosis":[1,26,113],"stimulating":[2],"proteins":[3,19,122],"of":[4,9,41,54,85,93,104,121],"p53":[5,55,88],"(ASPP)":[6],"family":[7,44,58,120],"consists":[8],"three":[10],"members,":[11,59],"ASPP1,":[12],"ASPP2":[13,72],"and":[14,29,31,56,61,64,71,131],"iASPP.":[15],"They":[16],"bind":[17],"to":[18,49,111,124,129],"that":[20,69],"are":[21],"key":[22],"players":[23],"in":[24,99],"controlling":[25],"(p53,":[27],"Bcl-2":[28],"RelA/p65)":[30],"cell":[32],"growth":[33,107],"(APCL,":[34],"PP1).":[35],"So":[36],"far,":[37],"the":[38,42,51,77,81,94,118],"best-known":[39],"function":[40,53,84],"ASPP":[43,119],"members":[45],"is":[46,102],"their":[47],"ability":[48,110],"regulate":[50],"apoptotic":[52,78],"its":[57,109],"p63":[60],"p73.":[62],"Biochemical":[63],"genetic":[65],"evidence":[66],"has":[67],"shown":[68],"ASPP1":[70],"activate,":[73],"whereas":[74],"iASPP":[75],"inhibits,":[76],"but":[79],"not":[80],"cell-cycle":[82,115],"arrest":[83],"p53.":[86],"tumour":[89,106],"suppressor":[90],"gene,":[91],"one":[92],"most":[95],"frequently":[96],"mutated":[97],"genes":[98],"human":[100],"cancer,":[101],"capable":[103],"suppressing":[105],"through":[108],"induce":[112],"or":[114],"arrest.":[116],"Thus,":[117],"helps":[123],"determine":[125],"how":[126],"cells":[127],"choose":[128],"die":[130],"may":[132],"therefore":[133],"be":[134],"a":[135],"novel":[136],"target":[137],"for":[138],"cancer":[139],"therapy.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
