{"id":"https://openalex.org/W1967707151","doi":"https://doi.org/10.3341/kjo.2012.26.5.378","title":"Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator","display_name":"Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1967707151","doi":"https://doi.org/10.3341/kjo.2012.26.5.378","mag":"1967707151","pmid":"https://pubmed.ncbi.nlm.nih.gov/23060725","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3464322"},"language":"en","primary_location":{"id":"doi:10.3341/kjo.2012.26.5.378","doi":"https://doi.org/10.3341/kjo.2012.26.5.378","is_oa":true,"landing_page_url":"https://doi.org/10.3341/kjo.2012.26.5.378","pdf_url":null,"source":{"id":"https://openalex.org/S158353152","display_name":"Korean Journal of Ophthalmology","issn_l":"1011-8942","issn":["1011-8942","2092-9382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","kci-registered","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319497","host_organization_name":"Korean Ophthalmological Society","host_organization_lineage":["https://openalex.org/P4310319497"],"host_organization_lineage_names":["Korean Ophthalmological Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3341/kjo.2012.26.5.378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059746269","display_name":"Ungsoo Samuel Kim","orcid":"https://orcid.org/0000-0003-2373-6240","observed_orcids":["https://orcid.org/0000-0003-2373-6240"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]},{"id":"https://openalex.org/I4210117632","display_name":"Kim's Eye Hospital","ror":"https://ror.org/02nh1np55","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210117632"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ungsoo Samuel Kim","raw_affiliation_strings":["Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I165028127","https://openalex.org/I4210117632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109420648","display_name":"Hyun Sub Oh","orcid":"https://orcid.org/0000-0001-9868-1438","observed_orcids":["https://orcid.org/0000-0001-9868-1438"]},"institutions":[{"id":"https://openalex.org/I4210103535","display_name":"Kangbuk Samsung Hospital","ror":"https://ror.org/013e76m06","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4210103535"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Sub Oh","raw_affiliation_strings":["Department of Ophthalmology, Kangbuk Samsung Medical Center, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kangbuk Samsung Medical Center, Seoul, Korea","institution_ids":["https://openalex.org/I4210103535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087042980","display_name":"Oh Woong Kwon","orcid":"https://orcid.org/0000-0001-9786-6756","observed_orcids":["https://orcid.org/0000-0001-9786-6756"]},"institutions":[{"id":"https://openalex.org/I4403928183","display_name":"Nune Eye Hospital","ror":"https://ror.org/01zmhvm70","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4403928183"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Oh Woong Kwon","raw_affiliation_strings":["Department of Ophthalmology, Noone Eye Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Noone Eye Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I4403928183"]}]},{"author_position":"middle","author":{"id":null,"display_name":"In Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"In Chung","raw_affiliation_strings":["Jung In Eye Clinic, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jung In Eye Clinic, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402791","display_name":"Sung\u2010Ho Lee","orcid":"https://orcid.org/0000-0001-5292-0747","observed_orcids":["https://orcid.org/0000-0001-5292-0747","https://orcid.org/0000-0003-2111-5504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung-Ho Lee","raw_affiliation_strings":["R & D Center, Eyegene Inc., Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R & D Center, Eyegene Inc., Seoul, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009468630","display_name":"Joon Haeng Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]},{"id":"https://openalex.org/I4210117632","display_name":"Kim's Eye Hospital","ror":"https://ror.org/02nh1np55","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210117632"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Joon Haeng Lee","raw_affiliation_strings":["Myung-Gok Eye Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myung-Gok Eye Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127","https://openalex.org/I4210117632"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009468630"],"corresponding_institution_ids":["https://openalex.org/I165028127","https://openalex.org/I4210117632"],"apc_list":{"value":250,"currency":"USD","value_usd":250},"apc_paid":{"value":250,"currency":"USD","value_usd":250},"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"26","issue":"5","first_page":"378","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.15940000116825104,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":1.0},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinal-toxicity","display_name":"retinal toxicity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8460000157356262},{"id":"https://openalex.org/keywords/retinal-cell-death","display_name":"retinal cell death","score":0.828000009059906},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.9188040494918823},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.7435019016265869},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.72902512550354},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.5728327035903931},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5149182081222534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4997696876525879},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.44642189145088196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4053795337677002},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39027637243270874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3499177098274231},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3254249095916748},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2938750684261322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2718296945095062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25358131527900696},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.24664106965065002},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.2056267261505127},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.07087638974189758},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.05237394571304321},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3341/kjo.2012.26.5.378","doi":"https://doi.org/10.3341/kjo.2012.26.5.378","is_oa":true,"landing_page_url":"https://doi.org/10.3341/kjo.2012.26.5.378","pdf_url":null,"source":{"id":"https://openalex.org/S158353152","display_name":"Korean Journal of Ophthalmology","issn_l":"1011-8942","issn":["1011-8942","2092-9382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","kci-registered","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319497","host_organization_name":"Korean Ophthalmological Society","host_organization_lineage":["https://openalex.org/P4310319497"],"host_organization_lineage_names":["Korean Ophthalmological Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3464322","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3464322/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3464322/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean J Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2463321","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3464322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23060725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean journal of ophthalmology : KJO","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3341/kjo.2012.26.5.378","doi":"https://doi.org/10.3341/kjo.2012.26.5.378","is_oa":true,"landing_page_url":"https://doi.org/10.3341/kjo.2012.26.5.378","pdf_url":null,"source":{"id":"https://openalex.org/S158353152","display_name":"Korean Journal of Ophthalmology","issn_l":"1011-8942","issn":["1011-8942","2092-9382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","kci-registered","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319497","host_organization_name":"Korean Ophthalmological Society","host_organization_lineage":["https://openalex.org/P4310319497"],"host_organization_lineage_names":["Korean Ophthalmological Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967707151.pdf","grobid_xml":"https://content.openalex.org/works/W1967707151.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W176826057","https://openalex.org/W1492773580","https://openalex.org/W1493701663","https://openalex.org/W1581310431","https://openalex.org/W1660366632","https://openalex.org/W1939232379","https://openalex.org/W1969982263","https://openalex.org/W1978190853","https://openalex.org/W2006044866","https://openalex.org/W2008537587","https://openalex.org/W2009018942","https://openalex.org/W2018732055","https://openalex.org/W2032358631","https://openalex.org/W2034035334","https://openalex.org/W2038431234","https://openalex.org/W2052983129","https://openalex.org/W2075177078","https://openalex.org/W2085273994"],"related_works":["https://openalex.org/W2052983129","https://openalex.org/W4234078953","https://openalex.org/W1975089240","https://openalex.org/W941159793","https://openalex.org/W4402581878","https://openalex.org/W3171817059","https://openalex.org/W2033808907","https://openalex.org/W1981373586","https://openalex.org/W3029952366","https://openalex.org/W2034738190"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,131],"effects":[2],"of":[3,41,61,70,122],"amiloride":[4,71,152,174,180,201],"on":[5],"cellular":[6],"toxicity":[7],"caused":[8],"by":[9],"tissue":[10],"plasminogen":[11],"activator":[12],"(tPA)":[13],"in":[14,46,77,202],"mouse":[15,90],"primary":[16],"retinal":[17,23,63,91,138,194,211],"cells":[18,64,92,195],"were":[19,26,36,102],"investigated.":[20],"METHODS:":[21],"Primary":[22],"cell":[24,59,139,158,166,212],"cultures":[25],"maintained":[27],"using":[28,52],"glial":[29],"conditioned":[30],"medium.":[31],"Commercial":[32],"tPA":[33,81,94,154],"and":[34,38,74,107,145,153,162,175,189],"L-arginine":[35,83,96,98,185],"added,":[37],"the":[39,47,58,88,114,142,146,157],"level":[40],"cyclic":[42,132],"guanosine":[43],"monophosphate":[44],"(cyclic-GMP)":[45],"culture":[48],"supernatant":[49],"was":[50,160],"assessed":[51],"an":[53],"ELISA":[54],"assay.":[55],"We":[56],"measured":[57],"viability":[60,159,167],"cultured":[62,89],"pretreated":[65],"with":[66,149,171,177],"three":[67],"different":[68],"concentrations":[69,101,203],"(1,":[72],"10,":[73],"100":[75,178],"\u00b5m)":[76],"addition":[78],"to":[79,93,169,193],"commercial":[80],"or":[82,97],"treatment.":[84],"RESULTS:":[85],"After":[86],"exposing":[87],"plus":[95],"alone,":[99],"cyclic-GMP":[100,123,188],"61.9":[103],"\u00b1":[104,109,125],"5.1":[105],"pmole/mL":[106],"63.1":[108],"6.1":[110],"pmole/mL,":[111,127],"respectively.":[112,164],"However,":[113,165],"control":[115,143],"group":[116,144,147],"had":[117],"a":[118],"significantly":[119],"lower":[120],"concentration":[121],"(37.2":[124],"3.4":[126],"p":[128],"<":[129],"0.01).":[130],"GMP-dissolved":[133],"solution":[134],"did":[135],"not":[136],"cause":[137],"death.":[140,213],"In":[141,199],"treated":[148],"1":[150],"\u00b5m":[151,173,179,207],"containing":[155],"L-arginine,":[156],"43.7%":[161],"44.5%,":[163],"increased":[168],"70.6%":[170],"10":[172,206],"78.4%":[176],"(p":[181],"=":[182],"0.015).":[183],"CONCLUSIONS:":[184],"increases":[186],"intracellular":[187],"may":[190],"give":[191],"rise":[192],"through":[196],"this":[197],"mechanism.":[198],"addition,":[200],"greater":[204],"than":[205],"protects":[208],"against":[209],"L-arginine-induced":[210]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}