{"id":"https://openalex.org/W1967679731","doi":"https://doi.org/10.1089/152581600750062228","title":"Perspectives on the Morphology and Biology of CD34-Negative Stem Cells","display_name":"Perspectives on the Morphology and Biology of CD34-Negative Stem Cells","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1967679731","doi":"https://doi.org/10.1089/152581600750062228","mag":"1967679731","pmid":"https://pubmed.ncbi.nlm.nih.gov/11177591"},"language":"en","primary_location":{"id":"doi:10.1089/152581600750062228","doi":"https://doi.org/10.1089/152581600750062228","is_oa":false,"landing_page_url":"https://doi.org/10.1089/152581600750062228","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematotherapy & Stem Cell Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009630355","display_name":"Ralf Huss","orcid":"https://orcid.org/0000-0002-6447-9300","observed_orcids":["https://orcid.org/0000-0002-6447-9300"]},"institutions":[{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralf Huss","raw_affiliation_strings":["Institute of Pathology, University of Munich, Germany","Institute of Pathology, University of Munich, Thalkirchner Str. 36, D-80337 Munich, Germany. Ralf.Huss@lrz.uni-muenchen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Munich, Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Institute of Pathology, University of Munich, Thalkirchner Str. 36, D-80337 Munich, Germany. Ralf.Huss@lrz.uni-muenchen.de","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009630355"],"corresponding_institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":1.1344,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.71578947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"783","last_page":"793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/bone-lining-cells","display_name":"bone lining cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/stem-cell-plasticity","display_name":"stem cell plasticity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hematopoietic-recovery","display_name":"hematopoietic recovery","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mesenchymal-differentiation","display_name":"mesenchymal differentiation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5860000252723694},{"id":"https://openalex.org/keywords/totipotent-stem-cells","display_name":"totipotent stem cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7345368266105652},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.656515896320343},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6429935097694397},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6187496185302734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5853583216667175},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5666518807411194},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5356020331382751},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.47370001673698425},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4660447835922241},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.43885868787765503},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.43626949191093445},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.42664024233818054},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4148303270339966},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3920142650604248},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.18536844849586487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1048857569694519},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06676942110061646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0551794171333313},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/152581600750062228","doi":"https://doi.org/10.1089/152581600750062228","is_oa":false,"landing_page_url":"https://doi.org/10.1089/152581600750062228","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematotherapy & Stem Cell Research","raw_type":"journal-article"},{"id":"pmid:11177591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11177591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematotherapy & stem cell research","raw_type":"Journal Article"},{"id":"mag:2402911986","doi":null,"is_oa":false,"landing_page_url":"https://online.liebertpub.com/doi/pdf/10.1089/152581600750062228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W37377977","https://openalex.org/W153768115","https://openalex.org/W187548590","https://openalex.org/W227086562","https://openalex.org/W1534731743","https://openalex.org/W1561424887","https://openalex.org/W1578515339","https://openalex.org/W1589551152","https://openalex.org/W1629791753","https://openalex.org/W1649547160","https://openalex.org/W1836124358","https://openalex.org/W1838336174","https://openalex.org/W1965953554","https://openalex.org/W1972124518","https://openalex.org/W1980871625","https://openalex.org/W1982022033","https://openalex.org/W1982086172","https://openalex.org/W1992396018","https://openalex.org/W1996735025","https://openalex.org/W2000367099","https://openalex.org/W2003548198","https://openalex.org/W2003686487","https://openalex.org/W2008412102","https://openalex.org/W2016433761","https://openalex.org/W2023365532","https://openalex.org/W2024456241","https://openalex.org/W2027538325","https://openalex.org/W2030118761","https://openalex.org/W2042021736","https://openalex.org/W2052260390","https://openalex.org/W2054979019","https://openalex.org/W2055918623","https://openalex.org/W2056598800","https://openalex.org/W2056878735","https://openalex.org/W2057406466","https://openalex.org/W2057847245","https://openalex.org/W2063486944","https://openalex.org/W2065699891","https://openalex.org/W2067900454","https://openalex.org/W2083632015","https://openalex.org/W2086886868","https://openalex.org/W2094574469","https://openalex.org/W2096773218","https://openalex.org/W2103546044","https://openalex.org/W2124073410","https://openalex.org/W2131388270","https://openalex.org/W2136287764","https://openalex.org/W2137956382","https://openalex.org/W2150951349","https://openalex.org/W2154992787","https://openalex.org/W2159999899","https://openalex.org/W2177231732","https://openalex.org/W2178162204","https://openalex.org/W2274051453","https://openalex.org/W2295535233","https://openalex.org/W2298389141","https://openalex.org/W2323132531","https://openalex.org/W2399600441","https://openalex.org/W2409889182","https://openalex.org/W2417213407","https://openalex.org/W2417869212","https://openalex.org/W2423976816","https://openalex.org/W2439105216","https://openalex.org/W4252030004","https://openalex.org/W4320800996"],"related_works":["https://openalex.org/W2299362120","https://openalex.org/W1987324712","https://openalex.org/W7027347304","https://openalex.org/W2394675823","https://openalex.org/W2439607268","https://openalex.org/W2027299299","https://openalex.org/W7096722930","https://openalex.org/W1996735025","https://openalex.org/W2360293520","https://openalex.org/W2474583326"],"abstract_inverted_index":{"The":[0,35,85,173,239],"CD34":[1],"antigen":[2],"is":[3,15,215],"the":[4,102,110,149,161,167,188,220,243,265],"classical":[5],"indicator":[6],"molecule":[7],"of":[8,22,41,45,61,112,151,170,175,197,219,226,245,258],"pluripotent":[9],"hematopoietic":[10,50,69,123,132,235],"stem":[11,26,51,55,64,119,141,153,177,222,247,275],"cells.":[12,56,172,276],"But":[13],"there":[14,214],"more":[16,18,73],"and":[17,38,53,83,98,108,133,205,236,255,261,264],"evidence":[19],"that":[20,130,213],"progenitors":[21],"a":[23,216],"yet":[24],"uncommitted":[25],"cell":[27,87,142,223,230],"population":[28],"do":[29],"not":[30,90],"express":[31],"this":[32],"surrogate":[33],"marker.":[34],"bone":[36,189,199],"marrow":[37,190],"other":[39],"sites":[40],"hematopoiesis":[42],"consist":[43],"also":[44,72,101],"fibroblast-like":[46,181],"stromal":[47,86,229],"cells,":[48,52,182],"quiescent":[49,180],"mesenchymal":[54,75,134,237],"Depending":[57],"on":[58],"their":[59],"stage":[60],"differentiation,":[62],"CD34-":[63,118,140,152,171,176,274],"cells":[65,120,154,178,201,227,248],"cannot":[66],"only":[67,91],"generate":[68],"progenitors,":[70],"but":[71,100,115],"specified":[74],"precursors,":[76],"such":[77,94],"as":[78,95,192,232,234],"osteoblasts,":[79],"chondrocytes,":[80],"myocytes,":[81],"adipocyts,":[82],"others.":[84],"compartment":[88],"produces":[89],"matrix":[92],"proteins,":[93],"collagens,":[96],"fibronectin":[97],"others,":[99],"essential":[103],"growth":[104],"factors,":[105],"which":[106,183],"initiate":[107],"support":[109],"differentiation":[111],"primary":[113],"quiescent,":[114],"eventually":[116],"activated":[117],"into":[121,242],"CD34+":[122],"progenitors.":[124,238],"In":[125],"vivo":[126],"studies":[127,210],"have":[128,211],"shown":[129],"long-term":[131],"reconstitution":[135,168],"can":[136,184],"be":[137,157,185],"achieved":[138],"with":[139,228,272],"lines,":[143],"isolated":[144],"from":[145],"various":[146,259],"sources,":[147],"although":[148],"frequency":[150],"seams":[155],"to":[156,267],"quite":[158],"low":[159],"among":[160],"progenitor":[162],"population.":[163],"Some":[164,196],"authors":[165],"deny":[166],"ability":[169],"majority":[174],"are":[179],"identified":[186],"in":[187],"biopsy":[191],"\"bone":[193],"lining":[194,200],"cells\".":[195],"those":[198],"show":[202],"protein":[203],"synthesis":[204],"contain":[206],"secretory":[207],"vesicles.":[208],"Recent":[209],"demonstrated":[212],"surprising":[217],"plasticity":[218],"earliest":[221],"population,":[224],"consisting":[225],"function":[231],"well":[233],"new":[240],"insights":[241],"biology":[244],"totipotent":[246],"give":[249],"us":[250],"novel":[251],"perspectives":[252],"for":[253],"cell-":[254],"gene":[256],"therapy":[257],"malignant":[260],"nonmalignant":[262],"diseases":[263],"possibility":[266],"replace":[268],"defective":[269],"organ":[270],"functions":[271],"autologous":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}