{"id":"https://openalex.org/W1967676693","doi":"https://doi.org/10.1097/fbp.0b013e3282f3d07f","title":"Comparison of the effects of desmethylimipramine on behavior in the forced swim test in peripubertal and adult rats","display_name":"Comparison of the effects of desmethylimipramine on behavior in the forced swim test in peripubertal and adult rats","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W1967676693","doi":"https://doi.org/10.1097/fbp.0b013e3282f3d07f","mag":"1967676693","pmid":"https://pubmed.ncbi.nlm.nih.gov/18195598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2741497"},"language":"en","primary_location":{"id":"doi:10.1097/fbp.0b013e3282f3d07f","doi":"https://doi.org/10.1097/fbp.0b013e3282f3d07f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fbp.0b013e3282f3d07f","pdf_url":null,"source":{"id":"https://openalex.org/S9181514","display_name":"Behavioural Pharmacology","issn_l":"0955-8810","issn":["0955-8810","1473-5849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2741497","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029621910","display_name":"Robert N. Pechnick","orcid":"https://orcid.org/0000-0002-2238-9964","observed_orcids":["https://orcid.org/0000-0002-2238-9964"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert N. Pechnick","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California 90034, USA. pechnickr@cshs.org","Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California 90034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California 90034, USA. pechnickr@cshs.org","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California 90034, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013195713","display_name":"Catherine J. Bresee","orcid":"https://orcid.org/0000-0002-5710-4906","observed_orcids":["https://orcid.org/0000-0002-5710-4906"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine J. Bresee","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066268017","display_name":"Charlene M. Manalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlene M. Manalo","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049632289","display_name":"Russell E. Poland","orcid":"https://orcid.org/0000-0003-4395-5811","observed_orcids":["https://orcid.org/0000-0003-4395-5811"]},"institutions":[{"id":"https://openalex.org/I4210163017","display_name":"Texas Health Resources Foundation","ror":"https://ror.org/05y2vby93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210163017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell E. Poland","raw_affiliation_strings":["Texas Health Resources, Arlington, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Health Resources, Arlington, TX, USA","institution_ids":["https://openalex.org/I4210163017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029621910"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":0.8965,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73800887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"81","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desmethylimipramine","display_name":"desmethylimipramine","score":1.0},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9800000190734863},{"id":"https://openalex.org/keywords/peripubertal-rats","display_name":"peripubertal rats","score":0.8379999995231628},{"id":"https://openalex.org/keywords/adolescent-depression","display_name":"adolescent depression","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.7429999709129333},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9900000095367432},{"id":"https://openalex.org/keywords/climbing-behavior","display_name":"climbing behavior","score":0.5180000066757202},{"id":"https://openalex.org/keywords/floating-behavior","display_name":"floating behavior","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.9211310148239136},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.8431977033615112},{"id":"https://openalex.org/C2779657639","wikidata":"https://www.wikidata.org/wiki/Q908843","display_name":"Tricyclic antidepressant","level":4,"score":0.7721567153930664},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6746708154678345},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5668874382972717},{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.5158233046531677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5150689482688904},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.5018794536590576},{"id":"https://openalex.org/C2778875871","wikidata":"https://www.wikidata.org/wiki/Q4764954","display_name":"Animal models of depression","level":4,"score":0.4503657817840576},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.44414210319519043},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42719951272010803},{"id":"https://openalex.org/C3019921246","wikidata":"https://www.wikidata.org/wiki/Q104853310","display_name":"Differential effects","level":2,"score":0.4116251468658447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3056447505950928},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30025726556777954},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.17664965987205505},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11435100436210632}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/fbp.0b013e3282f3d07f","doi":"https://doi.org/10.1097/fbp.0b013e3282f3d07f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fbp.0b013e3282f3d07f","pdf_url":null,"source":{"id":"https://openalex.org/S9181514","display_name":"Behavioural Pharmacology","issn_l":"0955-8810","issn":["0955-8810","1473-5849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Pharmacology","raw_type":"journal-article"},{"id":"pmid:18195598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18195598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:2741497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2741497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Behav Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2741497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2741497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Behav Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4430972782","display_name":"Differential Effects of Antidepressants in Adult and Developing Animals","funder_award_id":"R21MH078037","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5505572806","display_name":null,"funder_award_id":"078037","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1736508677","https://openalex.org/W1965111948","https://openalex.org/W1985645068","https://openalex.org/W1989274074","https://openalex.org/W1996001779","https://openalex.org/W2001006634","https://openalex.org/W2002398205","https://openalex.org/W2020472279","https://openalex.org/W2020833019","https://openalex.org/W2038807102","https://openalex.org/W2041380182","https://openalex.org/W2044865791","https://openalex.org/W2052035215","https://openalex.org/W2069422258","https://openalex.org/W2074020937","https://openalex.org/W2082569011","https://openalex.org/W2085272519","https://openalex.org/W2089299823","https://openalex.org/W2091064555","https://openalex.org/W2131167630","https://openalex.org/W2145906703","https://openalex.org/W2162865096","https://openalex.org/W3148068815","https://openalex.org/W4232604357"],"related_works":["https://openalex.org/W300427626","https://openalex.org/W2166127125","https://openalex.org/W2276225816","https://openalex.org/W69313005","https://openalex.org/W2463743803","https://openalex.org/W2082613323","https://openalex.org/W2102684551","https://openalex.org/W2006917968","https://openalex.org/W2044865791","https://openalex.org/W2020833019"],"abstract_inverted_index":{"Although":[0],"there":[1,13],"are":[2,14,31],"similarities":[3],"in":[4,16,41,73,81,105,108,112,147,161,164],"the":[5,17,21,89,94,97,106,131,135,142,154,165,169,172,177,181],"clinical":[6,175],"presentation":[7],"of":[8,88,137,144,180],"adolescent":[9,43,82],"and":[10,20,75,83,117,128,140,150,174],"adult":[11,76,84,151],"depression,":[12],"differences":[15],"biological":[18],"correlates":[19],"responses":[22],"to":[23,57,92,130,168,185],"pharmacologic":[24],"treatment.":[25],"Selective":[26],"serotonin":[27],"reuptake":[28],"inhibitor-type":[29],"antidepressants":[30,35,69],"efficacious,":[32],"but":[33,110],"tricyclic":[34,68,98,155],"have":[36],"no":[37],"or":[38,126],"limited":[39],"efficacy":[40,104],"treating":[42],"patients.":[44],"The":[45,86],"forced":[46],"swim":[47],"test":[48,93],"(FST)":[49],"is":[50,64,79],"a":[51],"widely":[52],"accepted":[53],"animal":[54],"model":[55],"used":[56],"screen":[58],"drugs":[59],"for":[60],"antidepressant":[61,99,156],"activity.":[62],"It":[63],"not":[65,111],"known":[66],"whether":[67],"produce":[70],"differential":[71],"effects":[72],"peripubertal":[74,149,162],"rats,":[77],"as":[78],"found":[80],"humans.":[85],"objective":[87],"study":[90],"was":[91],"hypothesis":[95],"that":[96],"desmethylimipramine":[100],"(DMI)":[101],"would":[102],"show":[103],"FST":[107,182],"adult,":[109],"peripubertal,":[113],"rats.":[114,152],"Thirty-day-old":[115],"(peripubertal)":[116],"112-day-old":[118],"(young":[119],"adult)":[120],"rats":[121,163],"were":[122],"pretreated":[123],"with":[124],"saline":[125],"DMI":[127,133,157],"subjected":[129],"FST.":[132,166],"reduced":[134],"amount":[136,143],"floating":[138],"behavior":[139,146],"increased":[141],"climbing":[145],"both":[148],"Thus,":[153],"has":[158],"antidepressant-like":[159],"activity":[160],"Owing":[167],"discrepancy":[170],"between":[171],"preclinical":[173],"data,":[176],"predictive":[178],"validity":[179],"might":[183],"need":[184],"be":[186],"reevaluated":[187],"across":[188],"different":[189],"age":[190],"groups.":[191]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
