{"id":"https://openalex.org/W1967656140","doi":"https://doi.org/10.1523/jneurosci.1960-11.2011","title":"APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling","display_name":"APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling","publication_year":2011,"publication_date":"2011-08-17","ids":{"openalex":"https://openalex.org/W1967656140","doi":"https://doi.org/10.1523/jneurosci.1960-11.2011","mag":"1967656140","pmid":"https://pubmed.ncbi.nlm.nih.gov/21849536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3319322"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1960-11.2011","doi":"https://doi.org/10.1523/jneurosci.1960-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1960-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/33/11756.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/31/33/11756.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005503268","display_name":"Carmela Matrone","orcid":"https://orcid.org/0000-0002-6719-0107","observed_orcids":["https://orcid.org/0000-0002-6719-0107"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmela Matrone","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, 00143 Rome, Italy. c.matrone@inmm.cnr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, 00143 Rome, Italy. c.matrone@inmm.cnr.it","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001186840","display_name":"Alessia Barbagallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessia P.M. Barbagallo","raw_affiliation_strings":["Department of Microbiology and Immunology , Einstein College of Medicine , Bronx , New York 10461 ,","lbert Einstein College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology , Einstein College of Medicine , Bronx , New York 10461 ,","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"lbert Einstein College of Medicine","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059778197","display_name":"Luca Rosario La Rosa","orcid":"https://orcid.org/0000-0002-0367-9149","observed_orcids":["https://orcid.org/0000-0002-0367-9149"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155481","display_name":"Institute of Cell Biology and Neurobiology","ror":"https://ror.org/040xhth73","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210155481"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca R. La Rosa","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, Italy","National Research Council of Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210155481"]},{"raw_affiliation_string":"National Research Council of Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029265169","display_name":"Fulvio Florenzano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fulvio Florenzano","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology , National Council of Research of Rome , 00143 Rome , Italy,","Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia , 00143 Rome , Italy,","National Research Council of Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology , National Council of Research of Rome , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"National Research Council of Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110136821","display_name":"Maria Teresa Ciotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria T. Ciotti","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology , National Council of Research of Rome , 00143 Rome , Italy,","National Research Council of Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology , National Council of Research of Rome , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210155236"]},{"raw_affiliation_string":"National Research Council of Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079024473","display_name":"Delio Mercanti","orcid":"https://orcid.org/0000-0001-8301-2098","observed_orcids":["https://orcid.org/0000-0001-8301-2098"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Delio Mercanti","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology , National Council of Research of Rome , 00143 Rome , Italy,","Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia , 00143 Rome , Italy,","National Research Council of Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology , National Council of Research of Rome , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia , 00143 Rome , Italy,","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"National Research Council of Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083842270","display_name":"Moses V. Chao","orcid":"https://orcid.org/0000-0002-6969-3744","observed_orcids":["https://orcid.org/0000-0002-6969-3744"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moses V. Chao","raw_affiliation_strings":["Molecular Neurobiology Program , Skirball Institute of Biomolecular Medicine , New York University , School of Medicine , New York , 10016 , and","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurobiology Program , Skirball Institute of Biomolecular Medicine , New York University , School of Medicine , New York , 10016 , and","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059406139","display_name":"Pietro Calissano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155481","display_name":"Institute of Cell Biology and Neurobiology","ror":"https://ror.org/040xhth73","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210155481"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Calissano","raw_affiliation_strings":["European Brain Research Institute, Rome, Italy","Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, Italy","National Research Council of Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Brain Research Institute, Rome, Italy","institution_ids":["https://openalex.org/I4210142264"]},{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210155481"]},{"raw_affiliation_string":"National Research Council of Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018070743","display_name":"Luciano D'adamio","orcid":"https://orcid.org/0000-0002-2204-9441","observed_orcids":["https://orcid.org/0000-0002-2204-9441","https://orcid.org/0000-0002-9820-4882"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciano D'Adamio","raw_affiliation_strings":["New Jersey Medical School (NJMS), Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Jersey Medical School (NJMS), Pharmacology","institution_ids":["https://openalex.org/I4402554120"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8438,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.90351174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"33","first_page":"11756","last_page":"11761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/app-phosphorylation","display_name":"APP phosphorylation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ngf-trka-signaling","display_name":"NGF/TrkA signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neurotrophic-signaling","display_name":"neurotrophic signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.5699999928474426},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7832672595977783},{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.7312909960746765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6250890493392944},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5899389982223511},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5889616012573242},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5821690559387207},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5559654831886292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5323866605758667},{"id":"https://openalex.org/C56703729","wikidata":"https://www.wikidata.org/wiki/Q14897872","display_name":"Low-affinity nerve growth factor receptor","level":4,"score":0.44956278800964355},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2392568290233612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2154998481273651},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17358553409576416},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15876445174217224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07298049330711365},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.1960-11.2011","doi":"https://doi.org/10.1523/jneurosci.1960-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1960-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/33/11756.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2327613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3319322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21849536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21849536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3319322","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3319322/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1960-11.2011","doi":"https://doi.org/10.1523/jneurosci.1960-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1960-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/33/11756.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1027275907","display_name":null,"funder_award_id":"AG025970","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1126923938","display_name":"Mechanism of action of neurotrophins","funder_award_id":"R01NS021072","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3191877473","display_name":null,"funder_award_id":"NS-21072","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4130647747","display_name":"BRI2 Familial British and Danish Dementias and Alzheimer's Disease","funder_award_id":"R01AG033007","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5499741614","display_name":"Novel Animal Models of Familial British, Danish and Alzheimer's Dementia","funder_award_id":"R21AG027139","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6558797254","display_name":"Mechanisms of action of TrkB transactivation","funder_award_id":"R56NS021072","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8232029972","display_name":"Gamma-secretase cleavage of the p75 receptor","funder_award_id":"R01AG025970","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000054720","display_name":null,"funder_award_id":"NS-21072","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000216170","display_name":null,"funder_award_id":"AG025970","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967656140.pdf","grobid_xml":"https://content.openalex.org/works/W1967656140.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1262527344","https://openalex.org/W1504283291","https://openalex.org/W1521975614","https://openalex.org/W1562792231","https://openalex.org/W1981734441","https://openalex.org/W2019208824","https://openalex.org/W2024776401","https://openalex.org/W2036020976","https://openalex.org/W2044207457","https://openalex.org/W2045855955","https://openalex.org/W2051646172","https://openalex.org/W2057742004","https://openalex.org/W2060411448","https://openalex.org/W2075663607","https://openalex.org/W2076259821","https://openalex.org/W2078195794","https://openalex.org/W2083917775","https://openalex.org/W2096410114","https://openalex.org/W2103126447","https://openalex.org/W2117513966","https://openalex.org/W2139985114","https://openalex.org/W2145784238","https://openalex.org/W2150617090","https://openalex.org/W2159018562"],"related_works":["https://openalex.org/W2135600369","https://openalex.org/W2008198229","https://openalex.org/W2336783249","https://openalex.org/W2075663607","https://openalex.org/W2042025152","https://openalex.org/W2632978006","https://openalex.org/W2018414133","https://openalex.org/W2528458814","https://openalex.org/W2004641424","https://openalex.org/W2258430337"],"abstract_inverted_index":{"The":[0],"pathogenic":[1],"model":[2],"of":[3,10,15,25,43,49,73,95,107,114,124,128,135,165,175,199,209,214,220],"Alzheimer's":[4],"disease":[5],"(AD)":[6],"posits":[7],"that":[8,53,62,104,132,170,178,192,225,235],"aggregates":[9],"amyloid":[11,16],"\u03b2,":[12],"a":[13,47,50,162,250],"product":[14],"precursor":[17],"protein":[18],"(APP)":[19],"processing,":[20,130],"cause":[21],"dementia.":[22],"However,":[23],"alterations":[24],"normal":[26],"APP":[27,45,74,85,129,136,138,166,179],"functions":[28,94,230],"could":[29],"contribute":[30],"to":[31,39,101,143,216],"AD":[32,243],"pathogenesis,":[33],"and":[34,126,140,150,177,183,194,211,234,245],"it":[35],"is":[36,46,89,98,119,161,240],"therefore":[37,99],"important":[38,100],"understand":[40],"the":[41,60,84,112,157,200,206,212,217,236],"role":[42,113],"APP.":[44,96],"member":[48],"gene":[51],"family":[52,75],"shows":[54],"functional":[55],"redundancy":[56],"as":[57,109,111,249],"documented":[58],"by":[59],"evidence":[61,223],"single":[63],"knock-out":[64],"mice":[65,69],"are":[66,231],"viable,":[67],"whereas":[68],"with":[70,121,147,181],"combined":[71],"deletions":[72],"genes":[76],"die":[77],"shortly":[78],"after":[79],"birth.":[80],"A":[81],"residue":[82],"in":[83,116,204,242],"intracellular":[86,144],"region,":[87],"Y(682),":[88,196],"indispensable":[90],"for":[91],"these":[92,226],"essential":[93],"It":[97],"identify":[102],"pathways":[103,145],"regulate":[105],"phosphorylation":[106,123,134,174],"Y(682)":[108,115],"well":[110],"vivo.":[117],"TrkA":[118,182,210],"associated":[120,146],"both":[122],"APP-Y(682)":[125],"alteration":[127],"suggesting":[131],"tyrosine":[133,173],"links":[137],"processing":[139],"neurotrophic":[141],"signaling":[142,159,202,238],"cellular":[148],"differentiation":[149],"survival.":[151],"Here":[152],"we":[153,189],"have":[154],"tested":[155],"whether":[156],"NGF/TrkA":[158,201,237],"pathway":[160,203,239],"physiological":[163],"regulator":[164],"phosphorylation.":[167],"We":[168],"find":[169],"NGF":[171],"induces":[172],"APP,":[176,193],"interacts":[180],"this":[184],"interaction":[185],"requires":[186],"Y(682).":[187],"Unpredictably,":[188],"also":[190],"uncover":[191],"specifically":[195],"regulates":[197],"activation":[198],"vivo,":[205],"subcellular":[207],"distribution":[208],"sensitivity":[213],"neurons":[215],"trophic":[218],"action":[219],"NGF.":[221],"This":[222],"suggests":[224],"two":[227],"membrane":[228],"protein's":[229],"strictly":[232],"interconnected":[233],"involved":[241],"pathogenesis":[244],"can":[246],"be":[247],"used":[248],"therapeutic":[251],"target.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
