{"id":"https://openalex.org/W1967581393","doi":"https://doi.org/10.1021/bi061370o","title":"Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein","display_name":"Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein","publication_year":2006,"publication_date":"2006-11-24","ids":{"openalex":"https://openalex.org/W1967581393","doi":"https://doi.org/10.1021/bi061370o","mag":"1967581393","pmid":"https://pubmed.ncbi.nlm.nih.gov/17154534"},"language":"en","primary_location":{"id":"doi:10.1021/bi061370o","doi":"https://doi.org/10.1021/bi061370o","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi061370o","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2579963","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020785070","display_name":"Christopher G. Bunick","orcid":"https://orcid.org/0000-0002-4011-8308","observed_orcids":["https://orcid.org/0000-0002-4011-8308"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G. Bunick","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016419649","display_name":"Michael R. Miller","orcid":"https://orcid.org/0000-0002-7726-0519","observed_orcids":["https://orcid.org/0000-0002-7726-0519"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Miller","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013001062","display_name":"Brian E. Fuller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian E. Fuller","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032492719","display_name":"Ellen Fanning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Fanning","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003392314","display_name":"Walter Chazin","orcid":"https://orcid.org/0000-0002-2180-0790","observed_orcids":["https://orcid.org/0000-0002-2180-0790"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walter J. Chazin","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and Center for Structural Biology, 5140 BIOSCI/MRBIII, and Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232-8725","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003392314"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4728,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.7883824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"50","first_page":"14965","last_page":"14979"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xpc","display_name":"XPC","score":0.75},{"id":"https://openalex.org/keywords/xeroderma-pigmentosum","display_name":"xeroderma pigmentosum","score":0.953000009059906},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9819999933242798},{"id":"https://openalex.org/keywords/rad23b","display_name":"RAD23B","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tfiih","display_name":"TFIIH","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.593999981880188},{"id":"https://openalex.org/keywords/protein-structure-model","display_name":"protein structure model","score":0.7210000157356262},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.9029910564422607},{"id":"https://openalex.org/C56149667","wikidata":"https://www.wikidata.org/wiki/Q14908082","display_name":"Transcription factor II H","level":5,"score":0.7707513570785522},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.724382758140564},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5162915587425232},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5140687227249146},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.49120089411735535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47313418984413147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45643413066864014},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.4413597881793976},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39775633811950684},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3524833917617798},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1599033772945404},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11910298466682434}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi061370o","doi":"https://doi.org/10.1021/bi061370o","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi061370o","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:17154534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17154534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2579963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2579963","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2579963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2579963","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G153582612","display_name":null,"funder_award_id":"P30 CA 68485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G231266942","display_name":null,"funder_award_id":"R01 GM040120","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2454636905","display_name":null,"funder_award_id":"R01 GM40120","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G290007438","display_name":null,"funder_award_id":"T32-GM 07347","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3485973333","display_name":null,"funder_award_id":"R01 GM 52948","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3834006785","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007347","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3892535034","display_name":null,"funder_award_id":"R01 GM 65484","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5096900011","display_name":null,"funder_award_id":"R01 GM065484","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5563094865","display_name":"Control of Simian Virus 40 and Cellular DNA Replication","funder_award_id":"R01GM052948","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G62769561","display_name":null,"funder_award_id":"P30 ES000267","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G725763919","display_name":null,"funder_award_id":"P30 CA 068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G905923675","display_name":null,"funder_award_id":"P50 ES00267","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W67100018","https://openalex.org/W1005028082","https://openalex.org/W1491876634","https://openalex.org/W1505189576","https://openalex.org/W1525382400","https://openalex.org/W1570121117","https://openalex.org/W1620981049","https://openalex.org/W1964961771","https://openalex.org/W1971517620","https://openalex.org/W1975365355","https://openalex.org/W1979123830","https://openalex.org/W1981938779","https://openalex.org/W1990849368","https://openalex.org/W1991501067","https://openalex.org/W1991794321","https://openalex.org/W1992803494","https://openalex.org/W1996516839","https://openalex.org/W2003840231","https://openalex.org/W2004069994","https://openalex.org/W2006338892","https://openalex.org/W2015403140","https://openalex.org/W2020252436","https://openalex.org/W2020484714","https://openalex.org/W2021285914","https://openalex.org/W2021798512","https://openalex.org/W2030776726","https://openalex.org/W2038163496","https://openalex.org/W2038616578","https://openalex.org/W2039299698","https://openalex.org/W2042843896","https://openalex.org/W2044036970","https://openalex.org/W2048238715","https://openalex.org/W2050021299","https://openalex.org/W2058693056","https://openalex.org/W2065184191","https://openalex.org/W2065283382","https://openalex.org/W2069661523","https://openalex.org/W2070184329","https://openalex.org/W2070821144","https://openalex.org/W2070847429","https://openalex.org/W2071628857","https://openalex.org/W2073641425","https://openalex.org/W2080605611","https://openalex.org/W2082054147","https://openalex.org/W2082667898","https://openalex.org/W2085261864","https://openalex.org/W2091194537","https://openalex.org/W2092525424","https://openalex.org/W2093381148","https://openalex.org/W2097520737","https://openalex.org/W2097718887","https://openalex.org/W2099249575","https://openalex.org/W2106315897","https://openalex.org/W2106443150","https://openalex.org/W2118619700","https://openalex.org/W2120999957","https://openalex.org/W2121909403","https://openalex.org/W2123456626","https://openalex.org/W2125625919","https://openalex.org/W2126064524","https://openalex.org/W2128004417","https://openalex.org/W2132629607","https://openalex.org/W2137450588","https://openalex.org/W2137842510","https://openalex.org/W2141783940","https://openalex.org/W2141885858","https://openalex.org/W2144362290","https://openalex.org/W2150797448","https://openalex.org/W2153753900","https://openalex.org/W2154098640","https://openalex.org/W2156798505","https://openalex.org/W2157165549","https://openalex.org/W2157811245","https://openalex.org/W2158714788","https://openalex.org/W2159036652","https://openalex.org/W2161199282","https://openalex.org/W2161682063","https://openalex.org/W3145894777","https://openalex.org/W4210400672","https://openalex.org/W4239885211"],"related_works":["https://openalex.org/W2086639667","https://openalex.org/W2031886171","https://openalex.org/W2113687378","https://openalex.org/W2080605611","https://openalex.org/W2040337006","https://openalex.org/W2080859786","https://openalex.org/W2108192168","https://openalex.org/W4251922679","https://openalex.org/W2122020045","https://openalex.org/W1967425207"],"abstract_inverted_index":{"XPC":[0,25,61,172,226,248],"is":[1,107,111,187],"a":[2,72,114,190,220,224],"940-residue":[3],"multidomain":[4],"protein":[5,200,242],"critical":[6,30],"for":[7,60,92,147],"the":[8,47,57,85,104,137,143,154,237,241],"sensing":[9],"of":[10,15,24,74,87,153,159,170,197,219,223,240],"aberrant":[11],"DNA":[12,138,160],"and":[13,36,63,79,90,127,167,207],"initiation":[14],"global":[16],"genome":[17],"nucleotide":[18],"excision":[19],"repair.":[20],"The":[21],"C-terminal":[22,80],"portion":[23,49],"(residues":[26,50],"492-940;":[27],"XPC-C)":[28],"has":[29],"interactions":[31,201],"with":[32,67,99,136,165,180,189,210],"DNA,":[33],"RAD23B,":[34],"CETN2,":[35],"TFIIH,":[37],"whereas":[38],"functional":[39,145],"roles":[40],"have":[41],"not":[42],"yet":[43],"been":[44],"assigned":[45],"to":[46,55,193,199,214],"N-terminal":[48],"1-491;":[51],"XPC-N).":[52],"In":[53],"order":[54],"analyze":[56],"molecular":[58],"basis":[59,86],"function":[62],"mutational":[64],"defects":[65],"associated":[66,188],"xeroderma":[68],"pigmentosum":[69],"(XP)":[70],"disease,":[71],"series":[73],"stable":[75,108],"bacterially":[76],"expressed":[77],"N-":[78],"fragments":[81],"were":[82],"designed":[83],"on":[84],"sequence":[88],"analysis":[89],"produced":[91],"biochemical":[93],"characterization.":[94],"Limited":[95],"proteolysis":[96],"experiments":[97],"combined":[98],"mass":[100],"spectrometry":[101],"revealed":[102,183],"that":[103,132,184],"full":[105],"XPC-C":[106,149,208],"but":[109],"XPC-N":[110,206],"not.":[112],"However,":[113],"previously":[115],"unrecognized":[116],"folded":[117,225],"helical":[118],"structural":[119,221],"domain":[120],"was":[121],"found":[122,176],"within":[123],"XPC-N,":[124],"XPC(156-325).":[125],"Pull-down":[126],"protease":[128],"protection":[129],"assays":[130],"demonstrated":[131],"XPC(156-325)":[133],"physically":[134],"interacts":[135],"repair":[139],"factor":[140],"XPA,":[141],"establishing":[142],"first":[144],"role":[146],"XPC-N.":[148],"exhibits":[150],"binding":[151,161],"characteristics":[152],"full-length":[155],"protein,":[156],"including":[157],"stimulation":[158],"by":[162],"physical":[163],"interaction":[164],"RAD23B":[166],"CETN2.":[168],"Analysis":[169],"an":[171],"missense":[173],"mutation":[174,186],"(Trp690Ser)":[175],"in":[177,204,245],"certain":[178],"patients":[179],"XP":[181],"disease":[182],"this":[185],"diminished":[191],"ability":[192],"bind":[194],"DNA.":[195],"Evidence":[196],"contributions":[198],"from":[202,236],"regions":[203],"both":[205],"along":[209],"recently":[211],"recognized":[212],"homologies":[213],"yeast":[215],"PNGase":[216],"prompted":[217],"construction":[218],"model":[222,229],"core.":[227],"This":[228],"offers":[230],"key":[231],"insights":[232],"into":[233],"how":[234],"domains":[235],"two":[238],"portions":[239],"may":[243],"cooperate":[244],"generating":[246],"specific":[247],"functions.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
