{"id":"https://openalex.org/W1967569258","doi":"https://doi.org/10.1371/journal.pone.0038202","title":"Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway","display_name":"Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway","publication_year":2012,"publication_date":"2012-06-04","ids":{"openalex":"https://openalex.org/W1967569258","doi":"https://doi.org/10.1371/journal.pone.0038202","mag":"1967569258","pmid":"https://pubmed.ncbi.nlm.nih.gov/22675522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366941"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0038202","doi":"https://doi.org/10.1371/journal.pone.0038202","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0038202","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038202&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038202&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jos\u00e9 Pe\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Pe\u00f1a","raw_affiliation_strings":["Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America. jpena360@yahoo.com","Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America","Graduate Group in Microbiology, Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America. jpena360@yahoo.com","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Graduate Group in Microbiology, Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027442064","display_name":"Eva Harris","orcid":"https://orcid.org/0000-0002-7238-4037","observed_orcids":["https://orcid.org/0000-0002-7238-4037"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eva Harris","raw_affiliation_strings":["Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America","Graduate Group in Microbiology, Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Graduate Group in Microbiology, Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027442064"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.3296,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.91625279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"e38202","last_page":"e38202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dengue-virus-type-2","display_name":"dengue virus type 2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9649999737739563},{"id":"https://openalex.org/keywords/xbp1","display_name":"XBP1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/atf6","display_name":"ATF6","score":0.996999979019165},{"id":"https://openalex.org/keywords/viral-translation","display_name":"viral protein synthesis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.827102780342102},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.8133759498596191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6103799939155579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5586385726928711},{"id":"https://openalex.org/C2781373781","wikidata":"https://www.wikidata.org/wiki/Q168790","display_name":"Brefeldin A","level":4,"score":0.4687134623527527},{"id":"https://openalex.org/C2778997996","wikidata":"https://www.wikidata.org/wiki/Q18036598","display_name":"ATF6","level":4,"score":0.4477717876434326},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.42955321073532104},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.3839960992336273},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2986990809440613},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.22445893287658691}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000071701","descriptor_name":"Regulatory Factor X Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071717","descriptor_name":"X-Box Binding Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051702","descriptor_name":"Activating Transcription Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051782","descriptor_name":"Sterol Regulatory Element Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0038202","doi":"https://doi.org/10.1371/journal.pone.0038202","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0038202","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038202&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2375745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3366941","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3366941","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22675522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22675522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.663.7831","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.663.7831","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366941/pdf/pone.0038202.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3b5e38f922794a488e56759133634dc1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3b5e38f922794a488e56759133634dc1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 6, p e38202 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/124311","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Early_Dengue_Virus_Protein_Synthesis_Induces_Extensive_Rearrangement_of_the_Endoplasmic_Reticulum_Independent_of_the_UPR_and_SREBP_2_Pathway/124311","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0038202","doi":"https://doi.org/10.1371/journal.pone.0038202","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0038202","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038202&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4172403133","display_name":"Role of cis & trans factors in dengue virus translation","funder_award_id":"R01AI052324","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8709553627","display_name":null,"funder_award_id":"AI052324","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967569258.pdf","grobid_xml":"https://content.openalex.org/works/W1967569258.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W56502103","https://openalex.org/W646980015","https://openalex.org/W1570016716","https://openalex.org/W1967502002","https://openalex.org/W1970106113","https://openalex.org/W1972482541","https://openalex.org/W1974942343","https://openalex.org/W1975218559","https://openalex.org/W1976098622","https://openalex.org/W1979164049","https://openalex.org/W1988988264","https://openalex.org/W1990057935","https://openalex.org/W1993651229","https://openalex.org/W2001744108","https://openalex.org/W2003599613","https://openalex.org/W2004739896","https://openalex.org/W2004920315","https://openalex.org/W2005129842","https://openalex.org/W2005867127","https://openalex.org/W2009616432","https://openalex.org/W2012893948","https://openalex.org/W2014452833","https://openalex.org/W2015406420","https://openalex.org/W2017356464","https://openalex.org/W2023422813","https://openalex.org/W2024970900","https://openalex.org/W2025366283","https://openalex.org/W2029052029","https://openalex.org/W2031277784","https://openalex.org/W2040468164","https://openalex.org/W2041506421","https://openalex.org/W2043708993","https://openalex.org/W2046661122","https://openalex.org/W2048258966","https://openalex.org/W2052214918","https://openalex.org/W2053500970","https://openalex.org/W2057967679","https://openalex.org/W2059655994","https://openalex.org/W2062956001","https://openalex.org/W2063099381","https://openalex.org/W2063306206","https://openalex.org/W2064895878","https://openalex.org/W2080560392","https://openalex.org/W2089198803","https://openalex.org/W2093373040","https://openalex.org/W2107948640","https://openalex.org/W2108394487","https://openalex.org/W2109815339","https://openalex.org/W2115420718","https://openalex.org/W2115425661","https://openalex.org/W2117672421","https://openalex.org/W2118120234","https://openalex.org/W2122312331","https://openalex.org/W2127144277","https://openalex.org/W2127639686","https://openalex.org/W2129181129","https://openalex.org/W2131210945","https://openalex.org/W2132444008","https://openalex.org/W2135404101","https://openalex.org/W2137293540","https://openalex.org/W2137662702","https://openalex.org/W2138486337","https://openalex.org/W2139340707","https://openalex.org/W2143952529","https://openalex.org/W2145393091","https://openalex.org/W2152665657","https://openalex.org/W2153291568","https://openalex.org/W2160928682","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3144302347","https://openalex.org/W4385336413","https://openalex.org/W2004739896","https://openalex.org/W1984178163","https://openalex.org/W2783209472","https://openalex.org/W2589120890","https://openalex.org/W2052214918","https://openalex.org/W7168536302","https://openalex.org/W2944141566","https://openalex.org/W2781785776"],"abstract_inverted_index":{"The":[0],"rearrangement":[1,41,64,92,135,179],"of":[2,29,44,67,78,99,107,112,118,142,180,192,204,208,227,241,247],"intracellular":[3,205],"membranes":[4],"has":[5],"been":[6],"long":[7],"reported":[8],"to":[9,25],"be":[10],"a":[11],"common":[12],"feature":[13],"in":[14,39,84,124],"diseased":[15],"cells.":[16],"In":[17],"this":[18,133],"study,":[19],"we":[20,61,88,162,184],"used":[21],"dengue":[22],"virus":[23],"(DENV)":[24],"study":[26,240],"the":[27,30,40,45,68,76,100,108,113,121,125,140,146,151,157,181,190,196,209,225,228,236],"role":[28],"unfolded":[31],"protein":[32,168,219],"response":[33],"(UPR)":[34],"and":[35,42,56,65,86,116,156,178,221,230,245],"sterol-regulatory-element-binding-protein-2":[36],"(SREBP-2)":[37],"pathway":[38],"expansion":[43,66,177],"endoplasmic":[46],"reticulum":[47],"(ER)":[48],"early":[49,71,93,211],"after":[50,72,94,212],"infection.":[51,74],"Using":[52,150],"laser":[53],"scanning":[54],"confocal":[55],"differential":[57],"interference":[58],"contrast":[59],"microscopy,":[60],"demonstrate":[62,104,185,201],"that":[63,90,105,132,164,186,202],"ER":[69,91,109,134],"occurs":[70],"DENV-2":[73,213],"Through":[75],"use":[77],"mouse":[79],"embryonic":[80],"fibroblast":[81],"cells":[82,144],"deficient":[83],"XBP1":[85],"ATF6,":[87],"show":[89,131,163],"DENV":[95],"infection":[96,188,214],"is":[97,110,136,174,215],"independent":[98,111],"UPR.":[101],"We":[102,129],"then":[103],"enlargement":[106],"SREBP-2":[114,231],"activation":[115],"upregulation":[117],"3-hydroxy-3-methylglutaryl-Coenzyme-A":[119],"reductase,":[120],"rate-limiting":[122],"enzyme":[123],"cholesterol":[126],"biosynthesis":[127],"pathway.":[128],"further":[130,239],"not":[137,171,223],"inhibited":[138],"by":[139,217],"treatment":[141],"DENV-infected":[143],"with":[145],"cholesterol-inhibiting":[147],"drug":[148],"lovastatin.":[149],"transcription":[152,173],"inhibitor":[153,160],"actinomycin":[154],"D":[155],"translation":[158],"elongation":[159],"cycloheximide,":[161],"de":[165],"novo":[166],"viral":[167,187,218],"synthesis":[169],"but":[170],"host":[172],"necessary":[175],"for":[176,238],"ER.":[182,197],"Lastly,":[183],"induces":[189],"reabsorption":[191],"lipid":[193],"droplets":[194],"into":[195],"Together,":[198],"these":[199],"results":[200],"modulation":[203],"membrane":[206,243],"architecture":[207],"cell":[210],"driven":[216],"expression":[220],"does":[222],"require":[224],"induction":[226],"UPR":[229],"pathways.":[232],"This":[233],"work":[234],"paves":[235],"way":[237],"virally-induced":[242],"rearrangements":[244],"formation":[246],"cubic":[248],"membranes.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}