{"id":"https://openalex.org/W1967548601","doi":"https://doi.org/10.1111/j.1651-2227.1971.tb06619.x","title":"LYMPHOBLASTIC TRANSFORMATION, CHROMOSOME PATTERN AND DELAYED\u2010TYPE SKIN REACTION IN ATAXIA TELANGIECTASIA","display_name":"LYMPHOBLASTIC TRANSFORMATION, CHROMOSOME PATTERN AND DELAYED\u2010TYPE SKIN REACTION IN ATAXIA TELANGIECTASIA","publication_year":1971,"publication_date":"1971-01-01","ids":{"openalex":"https://openalex.org/W1967548601","doi":"https://doi.org/10.1111/j.1651-2227.1971.tb06619.x","mag":"1967548601","pmid":"https://pubmed.ncbi.nlm.nih.gov/5100318"},"language":"en","primary_location":{"id":"doi:10.1111/j.1651-2227.1971.tb06619.x","doi":"https://doi.org/10.1111/j.1651-2227.1971.tb06619.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1651-2227.1971.tb06619.x","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112167471","display_name":"D. Sch\u00fcler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"D. SCHULER","raw_affiliation_strings":["Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064321226","display_name":"L Sch\u00f6ngut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"L. SCH\u00f6NGUT","raw_affiliation_strings":["Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075215683","display_name":"Endre Cserhati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"E. CSERHATI","raw_affiliation_strings":["Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. SIEGLER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J. SIEGLER","raw_affiliation_strings":["Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020003635","display_name":"G G\u00e1cs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G. G\u00c1CS","raw_affiliation_strings":["Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department (Head: E. Kerpel-Fronius) and First Department (Head: P. Gegesi Kiss) of Paediatrics, University Medical School, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112167471"],"corresponding_institution_ids":["https://openalex.org/I101202996"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.3625,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.583631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"60","issue":"1","first_page":"66","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":1.0},{"id":"https://openalex.org/keywords/lymphoblastic-transformation","display_name":"lymphoblastic transformation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chromosome-breakage","display_name":"chromosome breakage","score":0.7559999823570251},{"id":"https://openalex.org/keywords/delayed-type-skin-reaction","display_name":"delayed-type skin reaction","score":0.875},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.828000009059906},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.4050000011920929},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.9234665036201477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7894994616508484},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6203478574752808},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.5965293049812317},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.586901843547821},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.531362771987915},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.5138166546821594},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4431605339050293},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.4381547272205353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3962979018688202},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3318807780742645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31132179498672485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2745654284954071},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1370442807674408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10681870579719543},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.08133566379547119},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1651-2227.1971.tb06619.x","doi":"https://doi.org/10.1111/j.1651-2227.1971.tb06619.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1651-2227.1971.tb06619.x","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},{"id":"pmid:5100318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5100318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta paediatrica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W46168485","https://openalex.org/W1491589666","https://openalex.org/W1970380547","https://openalex.org/W1972069471","https://openalex.org/W1981354426","https://openalex.org/W1987837841","https://openalex.org/W1992461017","https://openalex.org/W2003009925","https://openalex.org/W2004405841","https://openalex.org/W2030060086","https://openalex.org/W2031862810","https://openalex.org/W2034435825","https://openalex.org/W2035247618","https://openalex.org/W2036911210","https://openalex.org/W2037019772","https://openalex.org/W2050361501","https://openalex.org/W2053269284","https://openalex.org/W2056606134","https://openalex.org/W2080033466","https://openalex.org/W2081933952","https://openalex.org/W2092093952","https://openalex.org/W2095328308","https://openalex.org/W2100766163","https://openalex.org/W2119278132","https://openalex.org/W2120134270","https://openalex.org/W2121548163","https://openalex.org/W2422031967","https://openalex.org/W2461947799","https://openalex.org/W2592163742","https://openalex.org/W2916161867","https://openalex.org/W4205890051","https://openalex.org/W4213023784","https://openalex.org/W4241770236","https://openalex.org/W4256671622","https://openalex.org/W4294184109"],"related_works":["https://openalex.org/W2402379022","https://openalex.org/W2020963949","https://openalex.org/W2056212005","https://openalex.org/W1965161960","https://openalex.org/W2149266265","https://openalex.org/W1981354426","https://openalex.org/W2335100379","https://openalex.org/W2058860048","https://openalex.org/W88320330","https://openalex.org/W2332089510"],"abstract_inverted_index":{"Summary":[0],"In":[1,25],"6":[2],"patients":[3],"suffering":[4],"from":[5],"ataxia":[6],"telangiectasia":[7],"morphological":[8],"evaluation":[9],"of":[10,17,30,38,65,86],"lymphoblastic":[11,40,46],"transformation":[12],"was":[13,21,32,55,60,89],"performed;":[14],"in":[15,81,91,104],"one":[16],"these":[18],"cases":[19,27],"it":[20],"repeated":[22],"four":[23],"times.":[24],"3":[26],"the":[28,36,39,50,53,63,69,72,105],"incorporation":[29],"3H\u2010thymidine":[31],"measured":[33],"to":[34],"examine":[35],"degree":[37,64],"transformation.":[41],"Both":[42],"methods":[43],"revealed":[44],"decreased":[45,66],"transformation,":[47,68],"though":[48],"with":[49],"last":[51],"method":[52],"decrease":[54],"much":[56],"greater.":[57],"No":[58],"correlation":[59],"found":[61,103],"between":[62],"blastic":[67],"infections":[70],"and":[71,96],"plasma":[73],"IgA":[74],"level.":[75],"Delayed\u2010type":[76],"skin":[77],"reactions":[78],"were":[79,102],"subnormal":[80],"varying":[82],"degrees.":[83],"Increased":[84],"frequency":[85],"chromosome":[87],"breakage":[88],"observed":[90],"1":[92],"case\u2013who":[93],"developed":[94],"malignancy":[95],"died\u2013":[97],"but":[98],"no":[99],"chromosomal":[100],"aberrations":[101],"three":[106],"other":[107],"cytogenetically":[108],"examined":[109],"patients.":[110]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
