{"id":"https://openalex.org/W1967537767","doi":"https://doi.org/10.1158/1538-7445.am2012-3927","title":"Abstract 3927: Loss of bHLH transcription factor Id4 modulates androgen receptor activity in prostate cancer progression","display_name":"Abstract 3927: Loss of bHLH transcription factor Id4 modulates androgen receptor activity in prostate cancer progression","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W1967537767","doi":"https://doi.org/10.1158/1538-7445.am2012-3927","mag":"1967537767"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-3927","doi":"https://doi.org/10.1158/1538-7445.am2012-3927","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3927","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061034435","display_name":"Jason P.W. Carey","orcid":"https://orcid.org/0000-0002-9729-1742","observed_orcids":["https://orcid.org/0000-0002-9729-1742"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason P. Carey","raw_affiliation_strings":["1Clark Atlanta Univ., Atlanta, GA","1Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clark Atlanta Univ., Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]},{"raw_affiliation_string":"1Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072992833","display_name":"Jaideep Chaudhary","orcid":"https://orcid.org/0000-0002-8793-4329","observed_orcids":["https://orcid.org/0000-0002-8793-4329"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaideep Chaudhary","raw_affiliation_strings":["1Clark Atlanta Univ., Atlanta, GA","1Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clark Atlanta Univ., Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]},{"raw_affiliation_string":"1Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52064589"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"3927","last_page":"3927"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/id4","display_name":"Id4","score":0.9589999914169312},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.9340000152587891},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/androgen-receptor-nuclear-translocation","display_name":"androgen receptor nuclear translocation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5929999947547913},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.9773898720741272},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8112950921058655},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6185779571533203},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5939037203788757},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5496585369110107},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5162824988365173},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4508379399776459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.430813729763031},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40681296586990356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35632503032684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3284863233566284},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.2845727205276489},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.23481544852256775},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-3927","doi":"https://doi.org/10.1158/1538-7445.am2012-3927","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3927","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995680337","https://openalex.org/W2071641998","https://openalex.org/W2126996873","https://openalex.org/W2118321738","https://openalex.org/W2164508669","https://openalex.org/W1549142756","https://openalex.org/W2010752901","https://openalex.org/W2194404780","https://openalex.org/W2504051591","https://openalex.org/W2085618049"],"abstract_inverted_index":{"Abstract":[0],"Inhibitor":[1],"of":[2,30,44,93,110,127,144,164,169,191,203,215,226,242,258,269,274,295,315,337,342],"differentiation":[3],"4":[4],"(Id4),":[5],"a":[6,22,60,94,149,188,236,275,281,304,319],"crucial":[7,61,237,305],"developmental":[8],"gene":[9,116],"also":[10,121,139,161,253],"expressed":[11],"in":[12,25,34,63,108,129,178,217,239,245,307],"the":[13,65,77,100,142,167,207,213,240,256,267,272,338,343],"normal":[14,197],"prostate,":[15],"has":[16],"been":[17],"shown":[18],"to":[19,70,131,166,196,224],"act":[20],"as":[21,146,172],"tumor":[23],"suppressor":[24],"prostate":[26,40,51,73,102,248,291,311,326],"cancer.":[27,41,312],"Promoter":[28],"hypermethylation":[29,301],"Id4":[31,45,58,97,118,233,263,285,299,316],"is":[32,221],"observed":[33,122,147,173],"several":[35,83],"advanced":[36,246,324],"stage":[37,247,325],"cancers":[38],"including":[39,86],"The":[42],"loss":[43,241],"expression":[46,286],"correlates":[47],"with":[48,133,159,206],"androgen":[49,68,71,124],"independent":[50,72],"cancer":[52,74,103,249,292,327],"progression.":[53,250,293],"Our":[54,229],"studies":[55,177],"suggest":[56,231,254],"that":[57,183,212,232,255],"plays":[59],"role":[62,238,306],"mediating":[64,76],"transition":[66],"from":[67],"dependent":[69],"by":[75,148,174],"AR":[78,111,114,134,137,156,165,208,227,243,259,288,296],"axis":[79],"potential":[80],"and":[81,89,112,271,287],"reprogramming":[82],"cellular":[84],"mechanisms":[85],"migration,":[87],"senescence":[88,192,216],"proliferation.":[90],"Stable":[91],"transfection":[92],"full":[95],"length":[96],"plasmid":[98],"into":[99],"androgen-independent":[101],"cell":[104],"line":[105],"DU145":[106,170,198],"resulted":[107],"re-expression":[109],"downstream":[113],"response":[115],"PSA.":[117],"transfected":[119,185,219],"cells":[120,171,186,199,205,220],"an":[123],"regulated":[125],"rate":[126,143,214,268],"proliferation":[128,270],"responsive":[130],"treatment":[132,158],"antagonist,":[135],"Casodex.":[136],"antagonism":[138,257],"significantly":[140],"reduced":[141],"migration":[145],"scratch":[150],"wound":[151],"assay.":[152],"Under":[153],"closer":[154],"observation,":[155],"antagonist":[157,209],"Casodex":[160,210],"inhibited":[162],"translocation":[163,261],"nucleus":[168],"immunofluorescence.":[175],"Previous":[176],"our":[179],"laboratory":[180],"have":[181],"demonstrated":[182],"DU145+Id4":[184,204,218],"undergo":[187],"significant":[189,282],"level":[190],"(\u223c":[193,200],"32%)":[194],"compared":[195],"4%).":[201],"Treatment":[202],"demonstrate":[211],"closely":[222,265],"related":[223],"inhibition":[225],"activity.":[228],"results":[230,252,279],"may":[234,302,317],"play":[235,303],"activity":[244,289,297],"These":[251,278],"nuclear":[260],"post":[262],"induction":[264,273,314],"regulates":[266],"senescent":[276],"phenotype.":[277],"provide":[280,318],"correlation":[283],"between":[284],"during":[290],"Loss":[294],"through":[298],"promoter":[300],"understanding":[308],"castration":[309],"resistant":[310],"Therefore,":[313],"novel":[320],"therapeutic":[321],"target":[322],"for":[323,346],"treatment.":[328],"Citation":[329],"Format:":[330],"{Authors}.":[331],"{Abstract":[332],"title}":[333],"[abstract].":[334],"In:":[335],"Proceedings":[336],"103rd":[339],"Annual":[340],"Meeting":[341],"American":[344],"Association":[345],"Cancer":[347,358],"Research;":[348],"2012":[349],"Mar":[350],"31-Apr":[351],"4;":[352],"Chicago,":[353],"IL.":[354],"Philadelphia":[355],"(PA):":[356],"AACR;":[357],"Res":[359],"2012;72(8":[360],"Suppl):Abstract":[361],"nr":[362],"3927.":[363],"doi:1538-7445.AM2012-3927":[364]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
