{"id":"https://openalex.org/W1967536639","doi":"https://doi.org/10.1101/gad.10.3.338","title":"U1 snRNA promotes the selection of nearby 5' splice sites by U6 snRNA in mammalian cells.","display_name":"U1 snRNA promotes the selection of nearby 5' splice sites by U6 snRNA in mammalian cells.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W1967536639","doi":"https://doi.org/10.1101/gad.10.3.338","mag":"1967536639","pmid":"https://pubmed.ncbi.nlm.nih.gov/8595884"},"language":"en","primary_location":{"id":"doi:10.1101/gad.10.3.338","doi":"https://doi.org/10.1101/gad.10.3.338","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.10.3.338","pdf_url":"http://genesdev.cshlp.org/content/10/3/338.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/10/3/338.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103165400","display_name":"Dong\u2010Youn Hwang","orcid":"https://orcid.org/0000-0002-2332-9461","observed_orcids":["https://orcid.org/0000-0002-2332-9461"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Y Hwang","raw_affiliation_strings":["Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, Pennsylvania 15261 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, Pennsylvania 15261 USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085370574","display_name":"Justus B. Cohen","orcid":"https://orcid.org/0000-0003-1208-1883","observed_orcids":["https://orcid.org/0000-0003-1208-1883"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Cohen","raw_affiliation_strings":["Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, Pennsylvania 15261 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, Pennsylvania 15261 USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"3","first_page":"338","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-splice-site-selection","display_name":"5' splice site selection","score":0.902999997138977},{"id":"https://openalex.org/keywords/u1-snrna","display_name":"U1 snRNA","score":0.9380000233650208},{"id":"https://openalex.org/keywords/u6-snrna","display_name":"U6 snRNA","score":1.0},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.8059999942779541},{"id":"https://openalex.org/keywords/rna-rna-base-pairing","display_name":"RNA-RNA base pairing","score":0.7519999742507935},{"id":"https://openalex.org/keywords/compensatory-mutations","display_name":"compensatory mutations","score":0.7129999995231628},{"id":"https://openalex.org/keywords/covariation-analysis","display_name":"covariation analysis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mammalian-cells","display_name":"mammalian cells","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C100299639","wikidata":"https://www.wikidata.org/wiki/Q284578","display_name":"Small nuclear RNA","level":5,"score":0.8649590015411377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8299875259399414},{"id":"https://openalex.org/C68483431","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"snRNP","level":5,"score":0.7478072047233582},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7063868641853333},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6854647994041443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.632253110408783},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.6235197186470032},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5478191375732422},{"id":"https://openalex.org/C62257209","wikidata":"https://www.wikidata.org/wiki/Q5487490","display_name":"Splice site mutation","level":5,"score":0.5365490913391113},{"id":"https://openalex.org/C14103023","wikidata":"https://www.wikidata.org/wiki/Q11681459","display_name":"Pairing","level":3,"score":0.532619833946228},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.501253604888916},{"id":"https://openalex.org/C52990999","wikidata":"https://www.wikidata.org/wiki/Q7252931","display_name":"Prp24","level":5,"score":0.4897334575653076},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35375452041625977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35133910179138184},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2884628176689148},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.16131258010864258},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12342265248298645},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C54101563","wikidata":"https://www.wikidata.org/wiki/Q124131","display_name":"Superconductivity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1101/gad.10.3.338","doi":"https://doi.org/10.1101/gad.10.3.338","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.10.3.338","pdf_url":"http://genesdev.cshlp.org/content/10/3/338.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmid:8595884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8595884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/gad.10.3.338","doi":"https://doi.org/10.1101/gad.10.3.338","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.10.3.338","pdf_url":"http://genesdev.cshlp.org/content/10/3/338.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967536639.pdf","grobid_xml":"https://content.openalex.org/works/W1967536639.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W84429989","https://openalex.org/W92004496","https://openalex.org/W131136481","https://openalex.org/W1553769217","https://openalex.org/W1555021163","https://openalex.org/W1771001171","https://openalex.org/W1786066781","https://openalex.org/W1836420458","https://openalex.org/W1861998732","https://openalex.org/W1965876012","https://openalex.org/W1968843636","https://openalex.org/W1973916539","https://openalex.org/W1977304564","https://openalex.org/W1979455742","https://openalex.org/W1982559739","https://openalex.org/W1984116290","https://openalex.org/W1984487835","https://openalex.org/W1988455121","https://openalex.org/W1991251351","https://openalex.org/W2001451148","https://openalex.org/W2010696389","https://openalex.org/W2014791263","https://openalex.org/W2015252183","https://openalex.org/W2015856496","https://openalex.org/W2020693389","https://openalex.org/W2021735978","https://openalex.org/W2022346667","https://openalex.org/W2023199595","https://openalex.org/W2024170620","https://openalex.org/W2024588724","https://openalex.org/W2027699344","https://openalex.org/W2041918235","https://openalex.org/W2042820257","https://openalex.org/W2047944486","https://openalex.org/W2049847998","https://openalex.org/W2057479447","https://openalex.org/W2075988374","https://openalex.org/W2080236124","https://openalex.org/W2080823878","https://openalex.org/W2090643890","https://openalex.org/W2097399934","https://openalex.org/W2109644636","https://openalex.org/W2133771794","https://openalex.org/W2134201576","https://openalex.org/W2148900689","https://openalex.org/W2157952189","https://openalex.org/W2172046880","https://openalex.org/W7096858812"],"related_works":["https://openalex.org/W1553769217","https://openalex.org/W2941313684","https://openalex.org/W2172046880","https://openalex.org/W1838953070","https://openalex.org/W2080420502","https://openalex.org/W3133858179","https://openalex.org/W2148900689","https://openalex.org/W2139312181","https://openalex.org/W1783342470","https://openalex.org/W92004496"],"abstract_inverted_index":{"Communication":[0],"between":[1,67],"exon":[2,10,68,116],"boundaries":[3,69],"is":[4,47,70],"a":[5,59,89,110,129,213],"central":[6,214],"feature":[7],"of":[8,13,65,88,109,128,132,137,158],"the":[9,29,45,52,62,82,124,138,228,235],"definition":[11],"model":[12],"pre-mRNA":[14],"splice-site":[15],"selection":[16,87,224],"and":[17,107,178,225],"an":[18,114],"exon-bridging":[19],"interaction":[20,54,93,229],"involving":[21],"U1":[22,167,180,198],"small":[23],"nuclear":[24],"RNA":[25],"(snRNA)":[26],"paired":[27],"with":[28,55,94,113,150,218],"5'":[30],"splice":[31,152],"site":[32],"(5'ss)":[33],"has":[34,39],"been":[35],"identified":[36],"previously.":[37],"It":[38],"become":[40],"increasingly":[41],"clear,":[42],"however,":[43],"that":[44,58,102,197],"5'ss":[46,86,111,159,202,223],"not":[48],"defined":[49],"relative":[50],"to":[51,80,195,200,206],"base-pairing":[53,92,217],"U1,":[56],"suggesting":[57],"connection":[60],"in":[61,84,123,155,221],"proposed":[63],"line":[64],"communication":[66],"missing.":[71],"To":[72],"explore":[73],"this":[74],"issue,":[75],"we":[76,100],"have":[77],"first":[78,125],"sought":[79],"characterize":[81],"role":[83,215],"mammalian":[85,222],"previously":[90],"suggested":[91],"U6":[95,133,162,205,219],"snRNA.":[96],"Using":[97],"transfection":[98],"experiments,":[99],"show":[101],"mutations":[103,160],"at":[104],"positions":[105,127],"5":[106],"6":[108],"associated":[112],"internal":[115],"can":[117],"be":[118,231],"suppressed":[119],"by":[120,142,148,161,204],"compensatory":[121],"changes":[122],"two":[126,151],"conserved":[130],"hexanucleotide":[131],"RNA.":[134],"The":[135],"specificity":[136],"effect":[139],"was":[140,163,174],"established":[141,232],"covariation":[143],"experiments":[144,149],"as":[145,147],"well":[146],"sites":[153,185],"arranged":[154],"tandem.":[156],"Suppression":[157],"more":[164,186],"efficient":[165],"when":[166,172],"could":[168],"pair":[169],"nearby":[170],"than":[171,188],"pairing":[173],"restored":[175],"further":[176],"away":[177],"individual":[179],"RNAs":[181],"stimulated":[182],"U6-defined":[183],"proximal":[184],"efficiently":[187],"distal":[189],"sites.":[190],"These":[191],"results":[192],"are":[193],"interpreted":[194],"suggest":[196],"acts":[199],"direct":[201],"choice":[203],"matching":[207],"sequences":[208],"nearby.":[209],"Our":[210],"work":[211],"supports":[212],"for":[216],"snRNA":[220],"suggests":[226],"how":[227],"may":[230],"properly":[233],"despite":[234],"limited":[236],"complementarity":[237],"involved.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
