{"id":"https://openalex.org/W1967478802","doi":"https://doi.org/10.1016/s0960-894x(99)00327-3","title":"Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129","display_name":"Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W1967478802","doi":"https://doi.org/10.1016/s0960-894x(99)00327-3","mag":"1967478802","pmid":"https://pubmed.ncbi.nlm.nih.gov/10450976"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(99)00327-3","doi":"https://doi.org/10.1016/s0960-894x(99)00327-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(99)00327-3","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047495331","display_name":"Morihiro Mitsuya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morihiro Mitsuya","raw_affiliation_strings":["Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Ibaraki, Japan","Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Ibaraki, Japan","institution_ids":[]},{"raw_affiliation_string":"Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kumiko Kawakami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kumiko Kawakami","raw_affiliation_strings":["Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780658","display_name":"Yoshio Ogino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshio Ogino","raw_affiliation_strings":["Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keiko Miura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiko Miura","raw_affiliation_strings":["Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078572797","display_name":"Toshiaki Mase","orcid":"https://orcid.org/0000-0002-8354-5297","observed_orcids":["https://orcid.org/0000-0002-8354-5297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiaki Mase","raw_affiliation_strings":["Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banyu Tsukuba Research Institute in Collaboration With Merck Research Laboratories, Okubo-3, Tsukuba 300-2611, Ibaraki, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.1484,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.84064787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"9","issue":"14","first_page":"2037","last_page":"2038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.15729999542236328,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.11720000207424164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stereoselective-synthesis","display_name":"stereoselective synthesis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/diastereoselective-synthesis","display_name":"diastereoselective synthesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/michael-addition","display_name":"Michael addition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/enolates","display_name":"enolates","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cyclopentenones","display_name":"cyclopentenones","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hydrogenolysis","display_name":"hydrogenolysis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/enol-triflates","display_name":"enol triflates","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dioxolanes","display_name":"dioxolanes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/chiral-auxiliaries","display_name":"chiral auxiliaries","score":0.5730000138282776},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9454418420791626},{"id":"https://openalex.org/C2776666804","wikidata":"https://www.wikidata.org/wiki/Q2234483","display_name":"Dioxolane","level":2,"score":0.8109076023101807},{"id":"https://openalex.org/C21774173","wikidata":"https://www.wikidata.org/wiki/Q2462024","display_name":"Trifluoromethanesulfonate","level":3,"score":0.5697916150093079},{"id":"https://openalex.org/C2779572362","wikidata":"https://www.wikidata.org/wiki/Q15427958","display_name":"Trimethylsilyl trifluoromethanesulfonate","level":3,"score":0.5340391993522644},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.521340012550354},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4901202619075775},{"id":"https://openalex.org/C18616679","wikidata":"https://www.wikidata.org/wiki/Q1027170","display_name":"Aldol condensation","level":3,"score":0.46208852529525757},{"id":"https://openalex.org/C2777495281","wikidata":"https://www.wikidata.org/wiki/Q408053","display_name":"Enol","level":3,"score":0.4515319764614105},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.43059343099594116},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.4297049045562744},{"id":"https://openalex.org/C112423150","wikidata":"https://www.wikidata.org/wiki/Q642233","display_name":"Michael reaction","level":3,"score":0.42382362484931946},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.42351460456848145},{"id":"https://openalex.org/C2781200603","wikidata":"https://www.wikidata.org/wiki/Q420217","display_name":"Enol ether","level":3,"score":0.4178926348686218},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32566606998443604},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.13556891679763794},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08378130197525024},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000475","descriptor_name":"Alkenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(99)00327-3","doi":"https://doi.org/10.1016/s0960-894x(99)00327-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(99)00327-3","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:10450976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10450976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1564912721","https://openalex.org/W2027050537","https://openalex.org/W2060110594","https://openalex.org/W2145548027"],"related_works":["https://openalex.org/W2953200141","https://openalex.org/W4413773479","https://openalex.org/W1993291214","https://openalex.org/W2950785539","https://openalex.org/W2043205935","https://openalex.org/W2950784058","https://openalex.org/W2001236676","https://openalex.org/W2011973350","https://openalex.org/W2084746042","https://openalex.org/W2011520734"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
