{"id":"https://openalex.org/W1967375142","doi":"https://doi.org/10.1158/1538-7445.am2011-lb-447","title":"Abstract LB-447: Non-steroidal anti-inflammatory drugs and brain cancer","display_name":"Abstract LB-447: Non-steroidal anti-inflammatory drugs and brain cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1967375142","doi":"https://doi.org/10.1158/1538-7445.am2011-lb-447","mag":"1967375142"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-lb-447","doi":"https://doi.org/10.1158/1538-7445.am2011-lb-447","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-lb-447","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073843147","display_name":"Sarah E. Daugherty","orcid":"https://orcid.org/0000-0002-4148-2881","observed_orcids":["https://orcid.org/0000-0002-4148-2881"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Daugherty","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steve Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Moore","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037297600","display_name":"Ruth M. Pfeiffer","orcid":"https://orcid.org/0000-0001-7791-2698","observed_orcids":["https://orcid.org/0000-0001-7791-2698"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Pfeiffer","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056263027","display_name":"Yikyung Park","orcid":"https://orcid.org/0000-0002-6281-489X","observed_orcids":["https://orcid.org/0000-0002-6281-489X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yikyung Park","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002103948","display_name":"Preetha Rajaraman","orcid":"https://orcid.org/0000-0001-6649-999X","observed_orcids":["https://orcid.org/0000-0001-6649-999X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Preetha Rajaraman","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"LB","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9959999918937683},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/brain-cancer-risk","display_name":"brain cancer risk","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nsaid-use","display_name":"NSAID use","score":0.6669999957084656},{"id":"https://openalex.org/keywords/nih-aarp-diet-and-health-study","display_name":"NIH-AARP Diet and Health Study","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prospective-cohort-study","display_name":"prospective cohort","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8578486442565918},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.8278863430023193},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7260634899139404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6754747033119202},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6258506178855896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6050000190734863},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6030998229980469},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5242460370063782},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5052018761634827},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4838313162326813},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.441464900970459},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.07278507947921753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-lb-447","doi":"https://doi.org/10.1158/1538-7445.am2011-lb-447","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-lb-447","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130829672","https://openalex.org/W2136859137","https://openalex.org/W7096983609","https://openalex.org/W2504834966","https://openalex.org/W2055072779","https://openalex.org/W2903250557","https://openalex.org/W1968149589","https://openalex.org/W2282925562","https://openalex.org/W1524475544","https://openalex.org/W2891380898"],"abstract_inverted_index":{"Abstract":[0],"Several":[1],"case-control":[2],"studies":[3,44],"have":[4,29],"suggested":[5],"that":[6],"non-steroidal":[7],"anti-inflammatory":[8],"drugs":[9],"reduce":[10],"risk":[11,170,197,229],"for":[12,131,252],"glioblastoma":[13,76,150,177,204,233],"multiforme,":[14,77],"a":[15,79,105],"very":[16],"aggressive":[17],"form":[18],"of":[19,37,49,69,91,136,167,171,198,230,243,248],"brain":[20,40,50],"cancer.":[21],"Limited":[22],"prospective":[23,81,218],"investigations,":[24],"on":[25],"the":[26,56,65,83,126,244,249],"other":[27],"hand,":[28],"not":[30,54,221],"observed":[31,190],"an":[32,223],"association":[33,57,66,157,225],"between":[34,67,158,226],"regular":[35,159,192],"use":[36,68,96,160],"aspirin":[38,92,168],"and":[39,52,71,73,86,93,112,134,148,169,196,203,228],"cancer;":[41],"however,":[42],"these":[43],"generally":[45],"had":[46],"small":[47],"numbers":[48],"cancer,":[51],"did":[53],"investigate":[55],"with":[58,123,144],"NSAIDs":[59,70,194,227],"by":[60],"histologic":[61],"subtype.":[62],"We":[63],"investigated":[64],"glioma,":[72],"more":[74],"specifically":[75],"in":[78],"large":[80,217],"study,":[82],"NIH-AARP":[84],"Diet":[85],"Health":[87],"Study.":[88],"The":[89,139],"frequency":[90],"non-aspirin":[94,193],"NSAID":[95],"one":[97],"year":[98],"prior":[99],"to":[100,183,210],"baseline":[101],"was":[102],"ascertained":[103],"using":[104,119],"self-administered":[106],"questionnaire.":[107],"Study-specific":[108],"hazard":[109],"ratios":[110],"(HRs)":[111],"95%":[113,174,180,201,207],"confidence":[114],"intervals":[115],"(CIs)":[116],"were":[117,188],"estimated":[118],"Cox":[120],"regression":[121],"models":[122],"age":[124],"as":[125],"underlying":[127],"time":[128],"metric":[129],"adjusted":[130],"sex,":[132],"race,":[133],"history":[135],"heart":[137],"disease.":[138],"analysis":[140],"included":[141],"302,767":[142],"individuals,":[143],"341":[145],"incident":[146],"glioma":[147,172,199,231],"257":[149],"multiforme":[151,178,205],"cases.":[152],"Preliminary":[153],"results":[154],"indicated":[155],"no":[156],"(more":[161],"than":[162],"2":[163],"times":[164],"per":[165],"week)":[166],"(HR=1.16;":[173],"CI:0.87\u20131.56)":[175],"or":[176,232],"(HR=1.17;":[179],"CI:0.83\u20131.65)":[181],"compared":[182,209],"never":[184,211],"users.":[185,212],"Null":[186],"associations":[187],"also":[189],"among":[191],"users":[195],"(HR=0.90;":[200],"CI:0.65\u20131.25)":[202],"(HR=0.83;":[206],"CI:0.56\u20131.22)":[208],"Our":[213],"findings":[214],"from":[215],"this":[216],"study":[219],"do":[220],"support":[222],"inverse":[224],"multiforme.":[234],"Citation":[235],"Format:":[236],"{Authors}.":[237],"{Abstract":[238],"title}":[239],"[abstract].":[240],"In:":[241],"Proceedings":[242],"102nd":[245],"Annual":[246],"Meeting":[247],"American":[250],"Association":[251],"Cancer":[253,263],"Research;":[254],"2011":[255],"Apr":[256],"2-6;":[257],"Orlando,":[258],"FL.":[259],"Philadelphia":[260],"(PA):":[261],"AACR;":[262],"Res":[264],"2011;71(8":[265],"Suppl):Abstract":[266],"nr":[267],"LB-447.":[268],"doi:10.1158/1538-7445.AM2011-LB-447":[269]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}