{"id":"https://openalex.org/W1967349754","doi":"https://doi.org/10.1007/s00726-014-1838-4","title":"Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-\u03baB-dependent pathway that reduces uPA and MMP-9 expression","display_name":"Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-\u03baB-dependent pathway that reduces uPA and MMP-9 expression","publication_year":2014,"publication_date":"2014-09-22","ids":{"openalex":"https://openalex.org/W1967349754","doi":"https://doi.org/10.1007/s00726-014-1838-4","mag":"1967349754","pmid":"https://pubmed.ncbi.nlm.nih.gov/25245054"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-014-1838-4","doi":"https://doi.org/10.1007/s00726-014-1838-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00726-014-1838-4","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112268165","display_name":"Shu-Ching Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Ching Hsieh","raw_affiliation_strings":["Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063808289","display_name":"Jen\u2010Pi Tsai","orcid":"https://orcid.org/0000-0001-9405-8649","observed_orcids":["https://orcid.org/0000-0001-9405-8649"]},"institutions":[{"id":"https://openalex.org/I4405279312","display_name":"Dalin Tzu Chi Hospital","ror":"https://ror.org/019t5b256","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4405279312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jen-Pi Tsai","raw_affiliation_strings":["Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I4405279312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014260545","display_name":"Shun\u2010Fa Yang","orcid":"https://orcid.org/0000-0002-0365-7927","observed_orcids":["https://orcid.org/0000-0002-0365-7927"]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shun-Fa Yang","raw_affiliation_strings":["Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076566934","display_name":"Meng-Ju Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Meng-Ju Tang","raw_affiliation_strings":["Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025960594","display_name":"Yi\u2010Hsien Hsieh","orcid":"https://orcid.org/0000-0003-4942-1888","observed_orcids":["https://orcid.org/0000-0003-4942-1888"]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210104362"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yi-Hsien Hsieh","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, Chung Shan Medical University, Clinical Laboratory, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo N. Road, Taichung, Taiwan","Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan","Department of Biochemistry, School of Medicine, Chung Shan Medical University, Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, Chung Shan Medical University, Clinical Laboratory, Chung Shan Medical University Hospital, No. 110, Section 1, Chien-Kuo N. Road, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362","https://openalex.org/I91279580"]},{"raw_affiliation_string":"Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, Chung Shan Medical University, Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362","https://openalex.org/I91279580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025960594"],"corresponding_institution_ids":["https://openalex.org/I4210104362","https://openalex.org/I91279580"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":3.5402,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.94538621,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"46","issue":"12","first_page":"2809","last_page":"2822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.718999981880188},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.9039999842643738},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/jnk1-2-signaling","display_name":"JNK1/2 signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9309999942779541},{"id":"https://openalex.org/keywords/upa","display_name":"uPA","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6000000238418579},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8770890235900879},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8363978862762451},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7061023712158203},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.657864511013031},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6427187323570251},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4908521771430969},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.46953141689300537},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43493539094924927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4332429766654968},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.42301222681999207},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.42187997698783875},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3751369118690491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36252039670944214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3371613323688507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32151931524276733},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24844637513160706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23672524094581604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22535401582717896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07487335801124573},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00726-014-1838-4","doi":"https://doi.org/10.1007/s00726-014-1838-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00726-014-1838-4","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},{"id":"pmid:25245054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25245054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino acids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320325266","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W75273126","https://openalex.org/W142591619","https://openalex.org/W337221903","https://openalex.org/W1525305507","https://openalex.org/W1550667671","https://openalex.org/W1895627253","https://openalex.org/W1942625844","https://openalex.org/W1965536826","https://openalex.org/W1970205234","https://openalex.org/W1971837077","https://openalex.org/W1972692564","https://openalex.org/W1976271889","https://openalex.org/W1980520860","https://openalex.org/W1983017460","https://openalex.org/W1983544692","https://openalex.org/W1985035729","https://openalex.org/W1987784827","https://openalex.org/W1988339176","https://openalex.org/W1989305622","https://openalex.org/W1994193851","https://openalex.org/W1994578837","https://openalex.org/W1994735160","https://openalex.org/W1999629169","https://openalex.org/W1999976665","https://openalex.org/W2010485702","https://openalex.org/W2014285846","https://openalex.org/W2019953132","https://openalex.org/W2030103715","https://openalex.org/W2036073861","https://openalex.org/W2042318189","https://openalex.org/W2045912291","https://openalex.org/W2051171548","https://openalex.org/W2056547856","https://openalex.org/W2062604619","https://openalex.org/W2064911312","https://openalex.org/W2078823089","https://openalex.org/W2093664485","https://openalex.org/W2100358697","https://openalex.org/W2104195235","https://openalex.org/W2113704334","https://openalex.org/W2113796483","https://openalex.org/W2123014930","https://openalex.org/W2125126707","https://openalex.org/W2130378338","https://openalex.org/W2134277070","https://openalex.org/W2137052325","https://openalex.org/W2145108148","https://openalex.org/W2149342916","https://openalex.org/W2155459657","https://openalex.org/W2157541965","https://openalex.org/W2157811842","https://openalex.org/W2158373383","https://openalex.org/W2165176539","https://openalex.org/W2168242281","https://openalex.org/W2171998898","https://openalex.org/W2331206669","https://openalex.org/W2406118964","https://openalex.org/W2900042851","https://openalex.org/W3139763557","https://openalex.org/W4231451806","https://openalex.org/W6605874870"],"related_works":["https://openalex.org/W2217079347","https://openalex.org/W4286587514","https://openalex.org/W3030024424","https://openalex.org/W2131108298","https://openalex.org/W2114771939","https://openalex.org/W2593042761","https://openalex.org/W2597572544","https://openalex.org/W4295222520","https://openalex.org/W1525305507","https://openalex.org/W2513446203"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}