{"id":"https://openalex.org/W1967312191","doi":"https://doi.org/10.1177/0194599813495815a111","title":"Management of the Unknown Primary in the Era of HPV and Robotics","display_name":"Management of the Unknown Primary in the Era of HPV and Robotics","publication_year":2013,"publication_date":"2013-08-23","ids":{"openalex":"https://openalex.org/W1967312191","doi":"https://doi.org/10.1177/0194599813495815a111","mag":"1967312191"},"language":"en","primary_location":{"id":"doi:10.1177/0194599813495815a111","doi":"https://doi.org/10.1177/0194599813495815a111","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0194599813495815a111","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075197376","display_name":"Jason G. Newman","orcid":"https://orcid.org/0000-0002-4700-360X","observed_orcids":["https://orcid.org/0000-0002-4700-360X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason G. Newman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bert W. O'Malley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bert W. O'Malley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054896370","display_name":"Christopher H. Rassekh","orcid":"https://orcid.org/0000-0003-2487-0169","observed_orcids":["https://orcid.org/0000-0003-2487-0169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher H. Rassekh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064825362","display_name":"Alexander Lin","orcid":"https://orcid.org/0000-0003-1254-8324","observed_orcids":["https://orcid.org/0000-0003-1254-8324"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111841182","display_name":"Ara A. Chalian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ara A. Chalian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020796088","display_name":"Shayanne A. Lajud","orcid":"https://orcid.org/0000-0003-4992-9198","observed_orcids":["https://orcid.org/0000-0003-4992-9198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shayanne A. Lajud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109918850","display_name":"Gregory Steven Weinstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory S. Weinstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.07845969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"149","issue":"S2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-of-unknown-primary","display_name":"cancer of unknown primary","score":0.9860000014305115},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/transoral-robotic-surgery","display_name":"transoral robotic surgery","score":0.8799999952316284},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.953000009059906},{"id":"https://openalex.org/keywords/primary-tumor-identification","display_name":"primary tumor detection","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tongue-base","display_name":"tongue base","score":0.6790000200271606},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/frozen-section","display_name":"frozen section","score":0.6779999732971191},{"id":"https://openalex.org/keywords/en-bloc-resection","display_name":"en bloc resection","score":0.8820000290870667},{"id":"https://openalex.org/keywords/minimally-invasive-surgery","display_name":"minimally invasive surgery","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2908642260","wikidata":"https://www.wikidata.org/wiki/Q28455206","display_name":"Transoral robotic surgery","level":2,"score":0.8770090341567993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8522143959999084},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.5079010128974915},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4948717951774597},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4688739776611328},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.44320619106292725},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43313270807266235},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.42064398527145386},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4150879979133606},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.414995402097702},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39969173073768616},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3973824381828308},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3582037687301636},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3449740409851074},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34464913606643677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2955753207206726},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2280575931072235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/0194599813495815a111","doi":"https://doi.org/10.1177/0194599813495815a111","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0194599813495815a111","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1597884645","https://openalex.org/W2901594487","https://openalex.org/W4410802595","https://openalex.org/W7045124119","https://openalex.org/W1946963206","https://openalex.org/W4361016040","https://openalex.org/W4417107090","https://openalex.org/W4399897562","https://openalex.org/W1960699973","https://openalex.org/W4390667680"],"abstract_inverted_index":{"Objectives:":[0,43],"A":[1,88],"subset":[2,84],"of":[3,9,26,60,85,116,152,158,166,185,217,232],"patients":[4,28,55,113,133,154],"with":[5,15,58,114,188],"squamous":[6],"cell":[7],"carcinoma":[8,59],"the":[10,36,38,78,106,117,156,164,180,186,227],"head":[11,118],"and":[12,52,119,182,225],"neck":[13,120],"present":[14],"a":[16,46,82,97,172,214,222],"cervical":[17],"metastasis":[18],"from":[19,126,198],"an":[20,203],"unknown":[21,61],"primary":[22,41,62,79,107,146,218],"site.":[23,42,108],"Currently,":[24],"many":[25,209],"these":[27],"have":[29,170],"human":[30],"papillomavirus":[31],"(HPV)":[32],"positive":[33,138],"tumors,":[34],"making":[35],"oropharynx":[37],"most":[39],"likely":[40],"1)":[44],"Develop":[45],"minimally":[47,173],"invasive":[48,174],"approach":[49,75,101,125,176,224],"to":[50,95,104,129,162,196,202],"identify":[51],"definitively":[53],"treat":[54],"initially":[56],"diagnosed":[57],"(CUP)":[63],"using":[64,102,139,177,221],"transoral":[65],"robotic":[66],"surgery":[67],"(TORS).":[68],"Additionally,":[69],"we":[70,193],"anticipate":[71],"that":[72,121],"this":[73,124,191,233],"aggressive":[74],"will":[76],"yield":[77],"lesion":[80],"in":[81,150,208],"higher":[83],"patients.":[86,210],"Methods:":[87],"retrospective":[89],"chart":[90],"review":[91],"study":[92],"was":[93,148,160],"conducted":[94],"evaluate":[96],"novel":[98],"minimally\u2010invasive":[99],"management":[100,184],"TORS":[103,178],"assess":[105],"Results:":[109],"We":[110,169],"identified":[111,149],"12":[112,153],"CUP":[115],"had":[122],"undergone":[123],"December":[127],"2011":[128],"April":[130],"2012.":[131],"Ten":[132],"were":[134],"classified":[135],"as":[136,142],"HPV":[137],"p16":[140],"staining":[141],"surrogate":[143],"marker.":[144],"The":[145],"site":[147],"10":[151],"(83%),":[155],"majority":[157],"which":[159],"found":[161],"be":[163],"base":[165],"tongue.":[167],"Conclusions:":[168],"developed":[171],"surgical":[175],"for":[179,229],"diagnosis":[181],"subsequent":[183],"patient":[187],"CUP.":[189],"Using":[190],"algorithm,":[192],"are":[194],"able":[195],"move":[197],"frozen":[199],"section":[200],"directly":[201],"en":[204],"bloc":[205],"definitive":[206],"resection":[207],"Our":[211],"results":[212],"show":[213],"significant":[215],"rate":[216],"tumor":[219],"identification":[220],"robotic\u2010assisted":[223],"support":[226],"rationale":[228],"further":[230],"investigation":[231],"technique.":[234]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}