{"id":"https://openalex.org/W1967192525","doi":"https://doi.org/10.1097/00007890-198604000-00008","title":"ASSESSMENT OF PLASMA NEOPTERIN IN CLINICAL KIDNEY TRANSPLANTATION","display_name":"ASSESSMENT OF PLASMA NEOPTERIN IN CLINICAL KIDNEY TRANSPLANTATION","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W1967192525","doi":"https://doi.org/10.1097/00007890-198604000-00008","mag":"1967192525","pmid":"https://pubmed.ncbi.nlm.nih.gov/3515644"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-198604000-00008","doi":"https://doi.org/10.1097/00007890-198604000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-198604000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111518544","display_name":"A Sch\u00e4fer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. J. SCH\u00c4FER","raw_affiliation_strings":["Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059944744","display_name":"Volker Daniel","orcid":"https://orcid.org/0000-0001-8345-1031","observed_orcids":["https://orcid.org/0000-0001-8345-1031"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"V. DANIEL","raw_affiliation_strings":["Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077901407","display_name":"Kurt Dreikorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. DREIKORN","raw_affiliation_strings":["Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111845951","display_name":"Gerhard Opelz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. OPELZ","raw_affiliation_strings":["Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Immunology, Institute of Immunology, and Department of I'rology, Surgical Center, University of Heidelberg, Heidelberg. Federal Republic of germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":7.56,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.97695853,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"41","issue":"4","first_page":"454","last_page":"458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neopterin","display_name":"neopterin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/acute-tubular-necrosis","display_name":"acute tubular necrosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/delayed-graft-function","display_name":"delayed graft function","score":0.824999988079071},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.6140000224113464},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.7089999914169312},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/rejection-biomarkers","display_name":"rejection biomarkers","score":0.5789999961853027},{"id":"https://openalex.org/keywords/maintenance-dialysis","display_name":"chronic dialysis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/graft-function","display_name":"graft function","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2776603314","wikidata":"https://www.wikidata.org/wiki/Q908292","display_name":"Neopterin","level":2,"score":0.975024938583374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7909942269325256},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7310851812362671},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5808197259902954},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5801058411598206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5710014700889587},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5626721978187561},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5095053315162659},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4842219352722168},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.4760972261428833},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.44883981347084045},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.44338223338127136},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.4263978600502014},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4107438325881958}],"mesh":[{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011621","descriptor_name":"Pteridines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019798","descriptor_name":"Neopterin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-198604000-00008","doi":"https://doi.org/10.1097/00007890-198604000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-198604000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:3515644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3515644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2464331035","https://openalex.org/W1991499314","https://openalex.org/W2065192854","https://openalex.org/W1974130599","https://openalex.org/W2330198193","https://openalex.org/W2429775288","https://openalex.org/W2028038490","https://openalex.org/W2418687126","https://openalex.org/W2028199403","https://openalex.org/W2318428763"],"abstract_inverted_index":{"Serial":[0],"plasma":[1,25,97,221],"samples":[2],"of":[3,24,71,105,144,167,182,230,239,261],"172":[4],"kidney":[5],"transplant":[6],"recipients":[7],"and":[8,74,96,124,192,242,263],"42":[9],"chronic":[10],"dialysis":[11],"patients":[12,29,52,107,136,173],"were":[13,159,174,198,210],"evaluated":[14],"retrospectively":[15],"in":[16,128,162,171,220,247],"a":[17,31,54,66,69,87,217,236,255],"radioimmunoassay":[18],"to":[19,68,126,204,253,272],"determine":[20],"the":[21,131,152,180,243],"clinical":[22],"relevance":[23],"neopterin":[26,33,61,98,119,149,193,222,231,251],"levels.":[27],"Dialysis":[28],"had":[30,108,146],"higher":[32],"level":[34,120],"196":[35],"+/-":[36,40,47],"82":[37],"nmol/L":[38,73,123],"(mean":[39],"SD)":[41],"than":[42,190,196,225],"70":[43],"healthy":[44],"controls":[45],"(7":[46],"4":[48],"nmol/L).":[49],"In":[50,78],"45":[51],"with":[53,81,130,176,235],"completely":[55],"uneventful":[56],"postoperative":[57],"course,":[58],"elevated":[59],"pretransplant":[60],"levels":[62,150,209],"dropped":[63],"rapidly":[64],"within":[65,141],"week":[67],"mean":[70,118],"30":[72],"remained":[75],"stable":[76,82],"thereafter.":[77],"22":[79],"outpatients":[80],"graft":[83,111],"function":[84,112],"there":[85,215],"was":[86,121,216,233,245],"highly":[88],"significant":[89,218],"correlation":[90],"between":[91],"170":[92],"paired":[93],"serum":[94,132,186],"creatinine":[95,187,208],"values":[99],"(r":[100],"=":[101],"0.94).":[102],"A":[103,165],"group":[104],"13":[106],"experienced":[109],"delayed":[110],"(ATN)":[113],"without":[114],"rejection.":[115],"Their":[116],"one-week":[117],"100":[122],"continued":[125],"drop":[127],"parallel":[129],"creatinine.":[133],"Another":[134],"15":[135],"rejected":[137],"their":[138],"kidneys":[139],"irreversibly":[140],"3":[142],"weeks-6":[143],"them":[145],"extremely":[147],"high":[148],"during":[151],"rejection":[153,169,262],"process":[154],"(range":[155],"500-1000":[156],"nmol/L)":[157],"that":[158,268],"not":[160,211,270],"seen":[161],"other":[163],"patients.":[164],"total":[166],"169":[168],"episodes":[170],"43":[172],"treated":[175],"bolus-dose":[177],"cortisone.":[178],"On":[179],"day":[181],"bolus":[183,205],"therapy,":[184,207],"both":[185],"(P":[188,194,223],"less":[189,195,224],"0.002)":[191],"0.005)":[197],"elevated.":[199],"At":[200],"24":[201],"hours":[202],"prior":[203],"cortisone":[206],"significantly":[212],"elevated,":[213],"whereas":[214],"rise":[219],"0.01).":[226],"The":[227],"overall":[228],"sensitivity":[229,244],"increase":[232],"86%":[234],"17%":[237],"probability":[238],"false":[240],"positives,":[241],"95%":[246],"biopsy-proved":[248],"rejections.":[249],"Plasma":[250],"appears":[252],"be":[254],"useful":[256],"marker":[257],"for":[258,264],"early":[259],"detection":[260],"identifying":[265],"severe":[266],"rejections":[267],"are":[269],"responsive":[271],"treatment.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
