{"id":"https://openalex.org/W1967192516","doi":"https://doi.org/10.1128/jb.00069-15","title":"Membrane Protein Complex ExbB 4 -ExbD 1 -TonB 1 from Escherichia coli Demonstrates Conformational Plasticity","display_name":"Membrane Protein Complex ExbB 4 -ExbD 1 -TonB 1 from Escherichia coli Demonstrates Conformational Plasticity","publication_year":2015,"publication_date":"2015-03-24","ids":{"openalex":"https://openalex.org/W1967192516","doi":"https://doi.org/10.1128/jb.00069-15","mag":"1967192516","pmid":"https://pubmed.ncbi.nlm.nih.gov/25802296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420915"},"language":"en","primary_location":{"id":"doi:10.1128/jb.00069-15","doi":"https://doi.org/10.1128/jb.00069-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00069-15","pdf_url":"https://jb.asm.org/content/jb/197/11/1873.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jb.asm.org/content/jb/197/11/1873.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010832005","display_name":"Aleksandr Sverzhinsky","orcid":"https://orcid.org/0000-0003-1405-925X","observed_orcids":["https://orcid.org/0000-0003-1405-925X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aleksandr Sverzhinsky","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029973861","display_name":"Jacqueline W. Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jacqueline W. Chung","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082015812","display_name":"Justin C. Deme","orcid":"https://orcid.org/0000-0001-8811-9871","observed_orcids":["https://orcid.org/0000-0001-8811-9871"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Justin C. Deme","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080651750","display_name":"Lucien Fabre","orcid":"https://orcid.org/0000-0002-7597-5932","observed_orcids":["https://orcid.org/0000-0002-7597-5932"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lucien Fabre","raw_affiliation_strings":["Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024721631","display_name":"Kristian T. Levey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kristian T. Levey","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063976004","display_name":"Maria Plesa","orcid":"https://orcid.org/0000-0002-3055-2215","observed_orcids":["https://orcid.org/0000-0002-3055-2215"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maria Plesa","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078680895","display_name":"David M. Carter","orcid":"https://orcid.org/0000-0002-2517-8599","observed_orcids":["https://orcid.org/0000-0002-2517-8599"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David M. Carter","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083487513","display_name":"Patrick Lypaczewski","orcid":"https://orcid.org/0000-0002-5550-712X","observed_orcids":["https://orcid.org/0000-0002-5550-712X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick Lypaczewski","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"aDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085944891","display_name":"James W. Coulton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James W. Coulton","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":1.597,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83061105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"197","issue":"11","first_page":"1873","last_page":"1885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tonb","display_name":"TonB","score":0.824999988079071},{"id":"https://openalex.org/keywords/exbb","display_name":"ExbB","score":0.9190000295639038},{"id":"https://openalex.org/keywords/exbd","display_name":"ExbD","score":0.996999979019165},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.7319999933242798},{"id":"https://openalex.org/keywords/outer-membrane-receptor","display_name":"outer membrane receptor","score":0.753000020980835},{"id":"https://openalex.org/keywords/siderophore-transport","display_name":"siderophore transport","score":0.7390000224113464},{"id":"https://openalex.org/keywords/proton-motive-force","display_name":"proton motive force","score":0.7670000195503235},{"id":"https://openalex.org/keywords/conformational-plasticity","display_name":"conformational plasticity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/protein-complex-stoichiometry","display_name":"protein complex stoichiometry","score":0.7549999952316284},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6759999990463257},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.5699999928474426},{"id":"https://openalex.org/keywords/single-particle-electron-microscopy","display_name":"single-particle electron microscopy","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.8232789039611816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7597380876541138},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.644528865814209},{"id":"https://openalex.org/C171357686","wikidata":"https://www.wikidata.org/wiki/Q910130","display_name":"Chemiosmosis","level":4,"score":0.559075653553009},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.531857430934906},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5302747488021851},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.43342775106430054},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.412391722202301},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32611340284347534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11525028944015503},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.08912107348442078},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019897","descriptor_name":"Periplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.00069-15","doi":"https://doi.org/10.1128/jb.00069-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00069-15","pdf_url":"https://jb.asm.org/content/jb/197/11/1873.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4420915","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4420915","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:25802296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25802296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jb.00069-15","doi":"https://doi.org/10.1128/jb.00069-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00069-15","pdf_url":"https://jb.asm.org/content/jb/197/11/1873.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7385636932","display_name":null,"funder_award_id":"200709MOP-178048-BMA-CFAA-11449","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1967192516.pdf"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1522265835","https://openalex.org/W1526789957","https://openalex.org/W1538103162","https://openalex.org/W1542104700","https://openalex.org/W1552188451","https://openalex.org/W1554827914","https://openalex.org/W1558837374","https://openalex.org/W1576483777","https://openalex.org/W1581821440","https://openalex.org/W1594171188","https://openalex.org/W1608041937","https://openalex.org/W1619896608","https://openalex.org/W1804623734","https://openalex.org/W1831651235","https://openalex.org/W1893684462","https://openalex.org/W1907864415","https://openalex.org/W1946604786","https://openalex.org/W1963630264","https://openalex.org/W1963676019","https://openalex.org/W1964339096","https://openalex.org/W1967128212","https://openalex.org/W1969504421","https://openalex.org/W1973343883","https://openalex.org/W1979219785","https://openalex.org/W1982889726","https://openalex.org/W1983751391","https://openalex.org/W1989128783","https://openalex.org/W1991572871","https://openalex.org/W1993490021","https://openalex.org/W1999675516","https://openalex.org/W1999779721","https://openalex.org/W2000101353","https://openalex.org/W2005034781","https://openalex.org/W2009579167","https://openalex.org/W2009825304","https://openalex.org/W2010763768","https://openalex.org/W2012087369","https://openalex.org/W2016556161","https://openalex.org/W2016675163","https://openalex.org/W2017007541","https://openalex.org/W2018402481","https://openalex.org/W2019082498","https://openalex.org/W2029095560","https://openalex.org/W2029820720","https://openalex.org/W2039722695","https://openalex.org/W2043010220","https://openalex.org/W2045469817","https://openalex.org/W2048648175","https://openalex.org/W2049862828","https://openalex.org/W2051925784","https://openalex.org/W2062598925","https://openalex.org/W2068654340","https://openalex.org/W2072340170","https://openalex.org/W2073949924","https://openalex.org/W2075824676","https://openalex.org/W2078641571","https://openalex.org/W2083753880","https://openalex.org/W2084608838","https://openalex.org/W2084834775","https://openalex.org/W2088167775","https://openalex.org/W2088481648","https://openalex.org/W2095275032","https://openalex.org/W2098624375","https://openalex.org/W2099178424","https://openalex.org/W2099888935","https://openalex.org/W2100455255","https://openalex.org/W2100861268","https://openalex.org/W2101820146","https://openalex.org/W2104234755","https://openalex.org/W2108215051","https://openalex.org/W2108503897","https://openalex.org/W2108906526","https://openalex.org/W2113886669","https://openalex.org/W2120061656","https://openalex.org/W2121609949","https://openalex.org/W2122400865","https://openalex.org/W2124043681","https://openalex.org/W2128922041","https://openalex.org/W2130618669","https://openalex.org/W2132629607","https://openalex.org/W2140312315","https://openalex.org/W2146883345","https://openalex.org/W2149326970","https://openalex.org/W2149543447","https://openalex.org/W2150740602","https://openalex.org/W2151761446","https://openalex.org/W2157161325","https://openalex.org/W2159814816","https://openalex.org/W2164659462","https://openalex.org/W2167488177","https://openalex.org/W2168747862","https://openalex.org/W2170047619","https://openalex.org/W2171621506","https://openalex.org/W2415082724","https://openalex.org/W2460235865"],"related_works":["https://openalex.org/W7000956038","https://openalex.org/W7034061542","https://openalex.org/W2149326970","https://openalex.org/W7043547286","https://openalex.org/W2149543447","https://openalex.org/W2789388031","https://openalex.org/W4400568383","https://openalex.org/W7009485406","https://openalex.org/W2026891133","https://openalex.org/W2977846227"],"abstract_inverted_index":{"UNLABELLED:":[0],"Iron":[1],"acquisition":[2],"at":[3],"the":[4,14,20,26,124,164,188,203,209,215,230,263,267,287,295,315,330],"outer":[5],"membrane":[6,22],"(OM)":[7],"of":[8,19,29,41,52,62,73,80,87,131,146,179,193,208,232,237,294,307,332],"Gram-negative":[9,233],"bacteria":[10,234],"is":[11],"powered":[12],"by":[13,25,102,191,275],"proton":[15,162],"motive":[16],"force":[17],"(PMF)":[18],"cytoplasmic":[21],"(CM),":[23],"harnessed":[24],"CM-embedded":[27,296],"complex":[28,183,216,298,316],"ExbB,":[30],"ExbD,":[31,262],"and":[32,39,56,66,136,218,252,261,291],"TonB.":[33,257],"Its":[34],"stoichiometry,":[35,288],"ensemble":[36],"structural":[37,151,219,289,327],"features,":[38],"mechanism":[40,293],"action":[42],"are":[43,241],"unknown.":[44],"By":[45],"panning":[46],"combinatorial":[47],"phage":[48,125],"libraries,":[49],"periplasmic":[50,133],"regions":[51],"dimerization":[53,197],"between":[54],"ExbD":[55,159],"TonB":[57,181,194],"were":[58,90],"predicted.":[59],"Using":[60,310],"overexpression":[61],"full-length":[63],"His6-tagged":[64],"exbB-exbD":[65],"S-tagged":[67],"tonB,":[68],"we":[69,153,201,302,313],"purified":[70,94],"detergent-solubilized":[71],"complexes":[72,79],"ExbB-ExbD-TonB":[74,210,297],"from":[75],"Escherichia":[76],"coli.":[77],"Protein-detergent":[78],"\u223c230":[81],"kDa":[82],"with":[83,118,184,198,259],"a":[84,155,161,250,277,333],"hydrodynamic":[85],"radius":[86],"\u223c6.0":[88],"nm":[89],"similar":[91],"to":[92,111,176,269],"previously":[93],"ExbB\u2084-ExbD\u2082":[95],"complexes.":[96,309],"Significantly,":[97],"they":[98],"differed":[99],"in":[100,157,182,187,229,282,304,317],"electronegativity":[101],"native":[103],"agarose":[104],"gel":[105],"electrophoresis.":[106],"The":[107],"stoichiometry":[108],"was":[109],"determined":[110],"be":[112,174],"ExbB\u2084-ExbD\u2081-TonB\u2081.":[113,147],"Single-particle":[114],"electron":[115],"microscopy":[116],"agrees":[117],"this":[119],"stoichiometry.":[120],"Two-dimensional":[121],"averaging":[122],"supported":[123],"display":[126],"predictions,":[127],"showing":[128],"two":[129],"forms":[130],"ExbD-TonB":[132,324],"heterodimerization:":[134],"extensive":[135,196],"distal.":[137],"Three-dimensional":[138],"(3D)":[139],"particle":[140],"classification":[141],"showed":[142],"three":[143,318],"representative":[144],"conformations":[145],"Based":[148],"on":[149],"our":[150],"data,":[152],"propose":[154],"model":[156,334],"which":[158],"shuttles":[160],"across":[163],"CM":[165],"via":[166],"an":[167],"ExbB":[168,260],"interprotein":[169],"rearrangement.":[170],"Proton":[171],"translocation":[172],"would":[173],"coupled":[175],"ExbD-mediated":[177],"collapse":[178],"extended":[180],"ligand-loaded":[185],"receptors":[186],"OM,":[189],"followed":[190],"repositioning":[192],"through":[195],"ExbD.":[199],"Here":[200,301],"present":[202],"first":[204],"report":[205],"for":[206,243,255,335],"purification":[207],"complex,":[211],"molar":[212],"ratios":[213],"within":[214],"(4:1:1),":[217],"biology":[220],"that":[221,240,321],"provides":[222],"insights":[223],"into":[224],"3D":[225,311],"organization.":[226],"IMPORTANCE:":[227],"Receptors":[228],"OM":[231,270],"allow":[235],"entry":[236],"iron-bound":[238],"siderophores":[239],"necessary":[242],"pathogenicity.":[244],"Numerous":[245],"iron-acquisition":[246],"strategies":[247],"rely":[248],"upon":[249],"ubiquitous":[251],"unique":[253],"protein":[254],"energization:":[256],"Complexed":[258],"Ton":[264],"system":[265],"links":[266],"PMF":[268],"transport.":[271],"Blocking":[272],"iron":[273,337],"uptake":[274],"targeting":[276],"vital":[278],"nanomachine":[279],"holds":[280],"promise":[281],"therapeutics.":[283],"Despite":[284],"much":[285],"research,":[286],"arrangement,":[290],"molecular":[292],"remain":[299],"unreported.":[300],"demonstrate":[303],"vitro":[305],"evidence":[306],"ExbB\u2084-ExbD\u2081-TonB\u2081":[308],"EM,":[312],"reconstructed":[314],"conformational":[319],"states":[320],"show":[322],"variable":[323],"heterodimerization.":[325],"Our":[326],"observations":[328],"form":[329],"basis":[331],"TonB-mediated":[336],"acquisition.":[338]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
