{"id":"https://openalex.org/W1967189772","doi":"https://doi.org/10.1074/jbc.m705138200","title":"Glucose Directly Links to Lipid Metabolism through High Affinity Interaction with Peroxisome Proliferator-activated Receptor \u03b1","display_name":"Glucose Directly Links to Lipid Metabolism through High Affinity Interaction with Peroxisome Proliferator-activated Receptor \u03b1","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W1967189772","doi":"https://doi.org/10.1074/jbc.m705138200","mag":"1967189772","pmid":"https://pubmed.ncbi.nlm.nih.gov/18055466"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m705138200","doi":"https://doi.org/10.1074/jbc.m705138200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m705138200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m705138200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012136829","display_name":"Heather Ann Hostetler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A. Hostetler","raw_affiliation_strings":["Department of Physiology, Texas A&M University, College Station, Texas 77843-4467, USA","Department of Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Texas A&M University, College Station, Texas 77843-4467, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4467","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670326","display_name":"Huan Huang","orcid":"https://orcid.org/0000-0001-5392-2947","observed_orcids":["https://orcid.org/0000-0001-5392-2947"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan Huang","raw_affiliation_strings":["Department of Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4467","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056901612","display_name":"Ann B. Kier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann B. Kier","raw_affiliation_strings":["Department of Pathobiology, Texas A&M University, College Station, Texas 77843-4467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Texas A&M University, College Station, Texas 77843-4467","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046497078","display_name":"Friedhelm Schroeder","orcid":"https://orcid.org/0000-0002-3545-7962","observed_orcids":["https://orcid.org/0000-0002-3545-7962"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Friedhelm Schroeder","raw_affiliation_strings":["Department of Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4467","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046497078"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1801,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.75039088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"283","issue":"4","first_page":"2246","last_page":"2254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.4869999885559082},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7490000128746033},{"id":"https://openalex.org/keywords/src-1","display_name":"SRC-1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/retinoid-x-receptor-alpha","display_name":"retinoid X receptor alpha","score":0.8330000042915344},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.871999979019165},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/long-chain-fatty-acids","display_name":"long-chain fatty acids","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.8757133483886719},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.8604152202606201},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.7112767696380615},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5970718264579773},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5700781941413879},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5692604184150696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5388317704200745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4964221119880676},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4940474331378937},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.4579443335533142},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4488877058029175},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.44384053349494934},{"id":"https://openalex.org/C188413054","wikidata":"https://www.wikidata.org/wiki/Q18030677","display_name":"Peroxisome proliferator-activated receptor alpha","level":5,"score":0.4428289532661438},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.41455280780792236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39275094866752625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33485281467437744},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.21215727925300598},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.20183271169662476},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.11480054259300232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06681698560714722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047490","descriptor_name":"Retinoid X Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047490","descriptor_name":"Retinoid X Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056920","descriptor_name":"Nuclear Receptor Coactivator 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m705138200","doi":"https://doi.org/10.1074/jbc.m705138200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m705138200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18055466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18055466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m705138200","doi":"https://doi.org/10.1074/jbc.m705138200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m705138200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2543857501","display_name":"Intracellular trafficking of long chain fatty acyl-CoAs","funder_award_id":"F32DK066732","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G287201605","display_name":null,"funder_award_id":"DK41402","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3234955387","display_name":"FATTY ACID BINDING PROTEINS-LIGAND SPECIFICITY","funder_award_id":"R01DK041402","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G657011587","display_name":"The role of long chain acyl-CoAs in nuclear receptor regulation","funder_award_id":"K99DK077573","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6582150326","display_name":null,"funder_award_id":"DK-066732","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1492705364","https://openalex.org/W1908444498","https://openalex.org/W1965309337","https://openalex.org/W1969540020","https://openalex.org/W1972882325","https://openalex.org/W1974127600","https://openalex.org/W1976039913","https://openalex.org/W1977534047","https://openalex.org/W1979383399","https://openalex.org/W1979761686","https://openalex.org/W1985683101","https://openalex.org/W1989270637","https://openalex.org/W1995754186","https://openalex.org/W1997380618","https://openalex.org/W2005674716","https://openalex.org/W2007966392","https://openalex.org/W2016298359","https://openalex.org/W2023597944","https://openalex.org/W2027149291","https://openalex.org/W2027399327","https://openalex.org/W2033786341","https://openalex.org/W2034283257","https://openalex.org/W2037921429","https://openalex.org/W2045223517","https://openalex.org/W2047189513","https://openalex.org/W2050717908","https://openalex.org/W2057477742","https://openalex.org/W2075171810","https://openalex.org/W2077212752","https://openalex.org/W2085085319","https://openalex.org/W2089030169","https://openalex.org/W2099356672","https://openalex.org/W2102082802","https://openalex.org/W2105072053","https://openalex.org/W2111863581","https://openalex.org/W2116470680","https://openalex.org/W2129338435","https://openalex.org/W2145547330","https://openalex.org/W2150845777","https://openalex.org/W2162919259","https://openalex.org/W4253244719"],"related_works":["https://openalex.org/W3175412858","https://openalex.org/W2015543883","https://openalex.org/W2145854759","https://openalex.org/W2580780168","https://openalex.org/W2001961333","https://openalex.org/W2245803049","https://openalex.org/W2002923743","https://openalex.org/W2134270245","https://openalex.org/W3166927308","https://openalex.org/W2157351132"],"abstract_inverted_index":{"The":[0],"pathophysiology":[1],"of":[2,77,83,87,104,121,149],"diabetes":[3],"is":[4,111],"characterized":[5],"not":[6,134],"only":[7,135],"by":[8,131],"elevated":[9,13,138],"glucose":[10,32,34,65,150],"but":[11,144],"also":[12,145],"long":[14,139],"chain":[15,140],"fatty":[16,51,141],"acid":[17,52,142],"levels.":[18],"We":[19],"show":[20],"for":[21,113],"the":[22,26,81,90,102],"first":[23],"time":[24],"that":[25,109,127],"peroxisome":[27],"proliferator-activated":[28],"receptor-alpha":[29,93],"(PPARalpha)":[30],"binds":[31],"and":[33,54,75,124,126],"metabolites":[35,53],"with":[36,50,62,69,101],"high":[37],"affinity,":[38],"resulting":[39],"in":[40,80,95,99],"significantly":[41],"altered":[42],"PPARalpha":[43,48,60,67,88,110,132],"secondary":[44],"structure.":[45],"Glucose":[46],"decreased":[47],"interaction":[49,61,68],"steroid":[55,70],"receptor":[56,71],"coactivator-1":[57],"while":[58],"increasing":[59],"DNA.":[63],"Concomitantly,":[64],"increased":[66],"coactivator-1,":[72],"DNA":[73],"binding,":[74],"transactivation":[76,100],"beta-oxidation":[78],"pathways":[79],"presence":[82],"activating":[84],"ligands.":[85],"Heterodimerization":[86],"to":[89],"retinoid":[91],"X":[92],"resulted":[94],"even":[96],"larger":[97],"increases":[98],"addition":[103],"glucose.":[105],"These":[106],"data":[107],"suggest":[108],"responsible":[112],"maintaining":[114],"energy":[115],"homeostasis":[116],"through":[117,137,146],"a":[118],"concentration-dependent":[119],"regulation":[120],"both":[122],"lipids":[123],"sugars":[125],"hyperglycemic":[128],"injury":[129],"mediated":[130],"occurs":[133],"indirectly":[136],"levels":[143],"direct":[147],"action":[148],"on":[151],"PPARalpha.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}