{"id":"https://openalex.org/W1967126239","doi":"https://doi.org/10.1136/gutjnl-2013-304907.403","title":"PWE-115 Alpha-Fetoprotein Measurement in the Diagnosis of Hepatocellular Carcinoma in Real-Life Practice: A Multi-Centre, Retrospective Analysis","display_name":"PWE-115 Alpha-Fetoprotein Measurement in the Diagnosis of Hepatocellular Carcinoma in Real-Life Practice: A Multi-Centre, Retrospective Analysis","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W1967126239","doi":"https://doi.org/10.1136/gutjnl-2013-304907.403","mag":"1967126239"},"language":"en","primary_location":{"id":"doi:10.1136/gutjnl-2013-304907.403","doi":"https://doi.org/10.1136/gutjnl-2013-304907.403","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2013-304907.403","pdf_url":"https://gut.bmj.com/content/gutjnl/62/Suppl_1/A177.2.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/62/Suppl_1/A177.2.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070489144","display_name":"Kathryn V. C. Wright","orcid":"https://orcid.org/0000-0001-8298-4696","observed_orcids":["https://orcid.org/0000-0001-8298-4696"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K Wright","raw_affiliation_strings":["Gastroenterology, John Radcliffe Hospital, Oxford","1Gastroenterology, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]},{"raw_affiliation_string":"1Gastroenterology, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013697157","display_name":"Elizabeth Harrod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801034529","display_name":"Royal Berkshire Hospital","ror":"https://ror.org/019f36t97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801034529","https://openalex.org/I2801444876"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E Harrod","raw_affiliation_strings":["Gastroenterology, Royal Berkshire Hospital, Reading","2Gastroenterology, Royal Berkshire Hospital, Reading"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, Royal Berkshire Hospital, Reading","institution_ids":["https://openalex.org/I2801034529"]},{"raw_affiliation_string":"2Gastroenterology, Royal Berkshire Hospital, Reading","institution_ids":["https://openalex.org/I2801034529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058205391","display_name":"Gwilym James Webb","orcid":"https://orcid.org/0000-0002-0710-5644","observed_orcids":["https://orcid.org/0000-0002-0710-5644"]},"institutions":[{"id":"https://openalex.org/I2800648950","display_name":"Wycombe General Hospital","ror":"https://ror.org/02nw0wb75","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800648950","https://openalex.org/I2801227970"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Webb","raw_affiliation_strings":["Gastroenterology, High Wycombe Hospital, High Wycombe, UK","3Gastroenterology, High Wycombe Hospital, High Wycombe, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, High Wycombe Hospital, High Wycombe, UK","institution_ids":["https://openalex.org/I2800648950"]},{"raw_affiliation_string":"3Gastroenterology, High Wycombe Hospital, High Wycombe, UK","institution_ids":["https://openalex.org/I2800648950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010873271","display_name":"Jane D Collier","orcid":"https://orcid.org/0000-0002-7046-1713","observed_orcids":["https://orcid.org/0000-0002-7046-1713"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Collier","raw_affiliation_strings":["Gastroenterology, John Radcliffe Hospital, Oxford","1Gastroenterology, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]},{"raw_affiliation_string":"1Gastroenterology, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084316206","display_name":"Stephen A.C. Gorard","orcid":"https://orcid.org/0000-0002-9381-5991","observed_orcids":["https://orcid.org/0000-0002-9381-5991"]},"institutions":[{"id":"https://openalex.org/I2800648950","display_name":"Wycombe General Hospital","ror":"https://ror.org/02nw0wb75","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800648950","https://openalex.org/I2801227970"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Gorard","raw_affiliation_strings":["Gastroenterology, High Wycombe Hospital, High Wycombe, UK","3Gastroenterology, High Wycombe Hospital, High Wycombe, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, High Wycombe Hospital, High Wycombe, UK","institution_ids":["https://openalex.org/I2800648950"]},{"raw_affiliation_string":"3Gastroenterology, High Wycombe Hospital, High Wycombe, UK","institution_ids":["https://openalex.org/I2800648950"]}]},{"author_position":"last","author":{"id":null,"display_name":"A Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801034529","display_name":"Royal Berkshire Hospital","ror":"https://ror.org/019f36t97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801034529","https://openalex.org/I2801444876"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Evans","raw_affiliation_strings":["Gastroenterology, Royal Berkshire Hospital, Reading","2Gastroenterology, Royal Berkshire Hospital, Reading"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, Royal Berkshire Hospital, Reading","institution_ids":["https://openalex.org/I2801034529"]},{"raw_affiliation_string":"2Gastroenterology, Royal Berkshire Hospital, Reading","institution_ids":["https://openalex.org/I2801034529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1824,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57676966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"Suppl 1","first_page":"A177.2","last_page":"A178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.996999979019165},{"id":"https://openalex.org/keywords/ultrasound-surveillance","display_name":"ultrasound surveillance","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.8149999976158142},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/liver-cancer-screening","display_name":"liver cancer screening","score":0.41999998688697815},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/delayed-diagnosis","display_name":"delayed diagnosis","score":0.4300000071525574},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.3449999988079071},{"id":"https://openalex.org/keywords/cross-sectional-imaging","display_name":"cross-sectional imaging","score":0.5360000133514404},{"id":"https://openalex.org/keywords/easl-guidelines","display_name":"EASL guidelines","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8907839059829712},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7348080277442932},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5694004893302917},{"id":"https://openalex.org/C2910763605","wikidata":"https://www.wikidata.org/wiki/Q7705274","display_name":"Tertiary referral centre","level":2,"score":0.5630321502685547},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.5040632486343384},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.493882954120636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49129241704940796},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.47640693187713623},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44191691279411316},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4348306357860565},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.42148277163505554},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.10986271500587463}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/gutjnl-2013-304907.403","doi":"https://doi.org/10.1136/gutjnl-2013-304907.403","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2013-304907.403","pdf_url":"https://gut.bmj.com/content/gutjnl/62/Suppl_1/A177.2.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1136/gutjnl-2013-304907.403","doi":"https://doi.org/10.1136/gutjnl-2013-304907.403","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2013-304907.403","pdf_url":"https://gut.bmj.com/content/gutjnl/62/Suppl_1/A177.2.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967126239.pdf","grobid_xml":"https://content.openalex.org/works/W1967126239.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2072463067"],"related_works":["https://openalex.org/W2334003308","https://openalex.org/W2069305598","https://openalex.org/W2806208963","https://openalex.org/W2906711503","https://openalex.org/W2426515022","https://openalex.org/W2171017754","https://openalex.org/W1963834564","https://openalex.org/W2755065183","https://openalex.org/W2002944232","https://openalex.org/W2146568318"],"abstract_inverted_index":{"Introduction":[0],"In":[1],"hepatocellular":[2],"carcinoma":[3],"(HCC),":[4],"earlier":[5],"diagnosisimproves":[6],"outcome":[7],"but":[8],"the":[9,49,108,208,243,282],"optimum":[10],"method":[11],"of":[12,51,98,147,194,249,259,267,284,314,329,340],"surveillance":[13,29,56,192],"in":[14,54,134,154,157,160,168,175,178,182,189,204,226,228,247,316,321],"high-risk":[15],"groups":[16],"is":[17],"controversial.":[18],"Recent":[19],"AASLD":[20],"and":[21,79,85,107,141,162,180,198,303,325],"EASL":[22],"guidelines[1.2]":[23],"have":[24,262],"recommended":[25],"six-":[26,195],"monthly":[27,196],"ultrasound":[28],"(USS)":[30],"alone.":[31,144],"British":[32],"guidelines[3]":[33],"currently":[34],"recommend":[35],"combining":[36],"serial":[37,312],"alpha-fetoprotein":[38],"(aFP)":[39],"measurements":[40],"with":[41,94,118,165,236,318],"six-monthly":[42],"USS.":[43,307],"This":[44,59,308],"study":[45,63,309],"aimed":[46],"to":[47,127,323],"assess":[48],"role":[50],"aFP":[52,143,167,172,222,270,315],"measurement":[53,271,313],"HCC":[55,67,99,121,148,268],"programmes.":[57,277],"Methods":[58],"large":[60],"retrospective":[61],"multicentre":[62],"assessed":[64],"newly":[65,119],"diagnosed":[66,120,188],"over":[68],"a":[69,95,202,219,256,264],"5-year":[70],"period":[71,246],"(2006\u20132011)":[72],"at":[73],"three":[74],"centres:":[75],"two":[76],"general":[77],"hospitals":[78],"one":[80],"tertiary":[81],"referral":[82],"centre.":[83],"Electronic":[84],"multi-disciplinary":[86],"team":[87],"data":[88],"were":[89,100,105,132],"reviewed.":[90],"Results":[91],"111":[92],"patients":[93,117,260,317],"confirmed":[96,150],"diagnosis":[97,146,266],"identified.":[101],"Of":[102,129,185],"these,":[103,130],"91(81.9%)":[104],"male":[106],"median":[109],"age":[110],"was":[111,149,173,234,272],"69":[112],"years":[113],"(range":[114],"24\u201387).":[115],"52(46.8%)":[116],"had":[122,263],"established":[123,191],"liver":[124,152,319],"disease":[125],"prior":[126],"diagnosis.":[128],"21(40.4%)":[131],"participating":[133],"combined":[135,164],"USS-aFP":[136],"surveillance,":[137,231],"2(3.8%)":[138],"USS":[139,163,197,241,298],"alone":[140],"1(1.9%)":[142],"A":[145],"by":[151],"biopsy":[153,215],"43(38.7%),":[155],"CT":[156],"41(36.9%),":[158],"MRI":[159],"25(22.5%)":[161],"elevated":[166,174,221],"2(1.8%).":[169],"At":[170],"diagnosis,":[171],"81(73.0%),":[176],"normal":[177],"22(19.8%)":[179],"unmeasured":[181],"8(7.2%)":[183],"patients.":[184],"those":[186,229],"21":[187],"an":[190],"programme":[193],"aFP,":[199],"17(81.0%)":[200],"showed":[201],"rise":[203],"aFP.":[205],"When":[206],"assessing":[207],"trigger":[209],"for":[210,306],"confirmatory":[211],"cross-sectional":[212],"imaging":[213],"\u00b1":[214],"across":[216],"all":[217],"data,":[218],"solely":[220],"prompted":[223],"further":[224],"investigation":[225],"11(9.9%);":[227],"under":[230],"this":[232],"number":[233,258],"7(29.2%)":[235],"no":[237],"abnormality":[238],"detected":[239],"on":[240],"within":[242],"preceding":[244],"three-month":[245],"6(85.7%)":[248],"these.":[250],"Conclusion":[251],"These":[252],"results":[253],"demonstrate":[254],"that":[255],"significant":[257],"would":[261],"delayed":[265],"if":[269],"removed":[273],"from":[274],"UK":[275],"screening":[276,287],"Potential":[278],"contributing":[279],"factors":[280,296],"limiting":[281,297],"success":[283],"USS-":[285],"based":[286],"programmes":[288],"include:":[289],"small":[290],"lesion":[291],"size,":[292],"sonographer":[293],"error,":[294],"patient":[295],"accuracy":[299],"(e.g.":[300],"body":[301],"habitus)":[302],"irregular":[304],"attendance":[305],"supports":[310],"continued":[311],"cirrhosis":[320],"contrast":[322],"European":[324],"American":[326],"guidelines.":[327],"Disclosure":[328],"Interest":[330],"None":[331],"Declared.":[332],"References":[333],"Hepatology,":[334,341],"vol.":[335,342,347],"53(3)1020\u20131022,":[336],"Mar.":[337],"2011.":[338],"Journal":[339],"56(4)908\u2013943,":[343],"Apr.":[344],"2012":[345],"Gut,":[346],"52(3)iii1-iii8,":[348],"2003.":[349]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
