{"id":"https://openalex.org/W1967097739","doi":"https://doi.org/10.2217/17469600.1.4.427","title":"HIV-1 Gag Trafficking","display_name":"HIV-1 Gag Trafficking","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W1967097739","doi":"https://doi.org/10.2217/17469600.1.4.427","mag":"1967097739"},"language":"en","primary_location":{"id":"doi:10.2217/17469600.1.4.427","doi":"https://doi.org/10.2217/17469600.1.4.427","is_oa":false,"landing_page_url":"https://doi.org/10.2217/17469600.1.4.427","pdf_url":null,"source":{"id":"https://openalex.org/S190389492","display_name":"Future HIV Therapy","issn_l":"1746-9600","issn":["1746-9600","1746-9619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future HIV Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091809007","display_name":"Anjali Joshi","orcid":"https://orcid.org/0000-0002-7979-3212","observed_orcids":["https://orcid.org/0000-0002-7979-3212"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjali Joshi","raw_affiliation_strings":["National Cancer Institute at Frederick, Virus\u2013Cell Interaction Section, HIV Drug Resistance Program, Frederick, MD 21702\u20131201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute at Frederick, Virus\u2013Cell Interaction Section, HIV Drug Resistance Program, Frederick, MD 21702\u20131201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054660762","display_name":"Eric O. Freed","orcid":"https://orcid.org/0000-0003-3345-022X","observed_orcids":["https://orcid.org/0000-0003-3345-022X"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric O Freed","raw_affiliation_strings":["National Cancer Institute at Frederick, Virus\u2013Cell Interaction Section, HIV Drug Resistance Program, Bldg. 535/Rm 108, Sultan Street, Frederick, MD 21702\u20131201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute at Frederick, Virus\u2013Cell Interaction Section, HIV Drug Resistance Program, Bldg. 535/Rm 108, Sultan Street, Frederick, MD 21702\u20131201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0634,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71364594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"4","first_page":"427","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gag-protein","display_name":"Gag protein","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pr55gag","display_name":"Pr55gag","score":0.9850000143051147},{"id":"https://openalex.org/keywords/virus-assembly","display_name":"viral assembly","score":0.7929999828338623},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.7929999828338623},{"id":"https://openalex.org/keywords/matrix-domain","display_name":"matrix domain","score":0.9670000076293945},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7223948836326599},{"id":"https://openalex.org/C6881719","wikidata":"https://www.wikidata.org/wiki/Q5611048","display_name":"Group-specific antigen","level":3,"score":0.6372631788253784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5428552031517029},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5112955570220947},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4932243227958679},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.47631344199180603},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41824066638946533},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3229656219482422},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27834779024124146}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2217/17469600.1.4.427","doi":"https://doi.org/10.2217/17469600.1.4.427","is_oa":false,"landing_page_url":"https://doi.org/10.2217/17469600.1.4.427","pdf_url":null,"source":{"id":"https://openalex.org/S190389492","display_name":"Future HIV Therapy","issn_l":"1746-9600","issn":["1746-9600","1746-9619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future HIV Therapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W181778438","https://openalex.org/W272400546","https://openalex.org/W1532225053","https://openalex.org/W1560080751","https://openalex.org/W1576433430","https://openalex.org/W1579191879","https://openalex.org/W1594514074","https://openalex.org/W1637355600","https://openalex.org/W1758624082","https://openalex.org/W1762620449","https://openalex.org/W1813266103","https://openalex.org/W1965775500","https://openalex.org/W1969864242","https://openalex.org/W1977069053","https://openalex.org/W1978461631","https://openalex.org/W1980148932","https://openalex.org/W1980926787","https://openalex.org/W1981747825","https://openalex.org/W1982391580","https://openalex.org/W1982997055","https://openalex.org/W1990852843","https://openalex.org/W1991586131","https://openalex.org/W1993232578","https://openalex.org/W1993452562","https://openalex.org/W1993877052","https://openalex.org/W1996639027","https://openalex.org/W1999148331","https://openalex.org/W1999678180","https://openalex.org/W2000569926","https://openalex.org/W2001070158","https://openalex.org/W2002041526","https://openalex.org/W2004652094","https://openalex.org/W2008264122","https://openalex.org/W2009205890","https://openalex.org/W2011987706","https://openalex.org/W2012956482","https://openalex.org/W2013108726","https://openalex.org/W2014903703","https://openalex.org/W2017962609","https://openalex.org/W2018158124","https://openalex.org/W2021500400","https://openalex.org/W2023172957","https://openalex.org/W2023916724","https://openalex.org/W2028156315","https://openalex.org/W2029873308","https://openalex.org/W2030091131","https://openalex.org/W2030114206","https://openalex.org/W2031392025","https://openalex.org/W2032428846","https://openalex.org/W2033320393","https://openalex.org/W2034399323","https://openalex.org/W2034988569","https://openalex.org/W2035861820","https://openalex.org/W2037285840","https://openalex.org/W2039055702","https://openalex.org/W2053584325","https://openalex.org/W2054637102","https://openalex.org/W2055921223","https://openalex.org/W2056548409","https://openalex.org/W2056949914","https://openalex.org/W2057712924","https://openalex.org/W2058032164","https://openalex.org/W2058169924","https://openalex.org/W2059841928","https://openalex.org/W2060380070","https://openalex.org/W2060952336","https://openalex.org/W2062574001","https://openalex.org/W2062819360","https://openalex.org/W2064293112","https://openalex.org/W2066121768","https://openalex.org/W2067216245","https://openalex.org/W2083889661","https://openalex.org/W2084460699","https://openalex.org/W2085355019","https://openalex.org/W2095555197","https://openalex.org/W2097353604","https://openalex.org/W2099473567","https://openalex.org/W2099491642","https://openalex.org/W2102965972","https://openalex.org/W2107215466","https://openalex.org/W2107627347","https://openalex.org/W2107776366","https://openalex.org/W2110919913","https://openalex.org/W2115451854","https://openalex.org/W2115644744","https://openalex.org/W2115665262","https://openalex.org/W2117134676","https://openalex.org/W2122717735","https://openalex.org/W2124493183","https://openalex.org/W2124782017","https://openalex.org/W2130448025","https://openalex.org/W2132762790","https://openalex.org/W2133396499","https://openalex.org/W2140031117","https://openalex.org/W2142635775","https://openalex.org/W2146667353","https://openalex.org/W2153090499","https://openalex.org/W2155464947","https://openalex.org/W2157055613","https://openalex.org/W2157215645","https://openalex.org/W2158408725","https://openalex.org/W2159507231","https://openalex.org/W2160139994","https://openalex.org/W2160992936","https://openalex.org/W2162168512","https://openalex.org/W2162183496","https://openalex.org/W2165393757","https://openalex.org/W2168343203","https://openalex.org/W2170004857","https://openalex.org/W2172285292","https://openalex.org/W2472683954","https://openalex.org/W4211200857","https://openalex.org/W4249167162","https://openalex.org/W4249774679"],"related_works":["https://openalex.org/W2098437057","https://openalex.org/W1996779413","https://openalex.org/W2013760113","https://openalex.org/W7096032220","https://openalex.org/W82851467","https://openalex.org/W2401346588","https://openalex.org/W2020175674","https://openalex.org/W1982692592","https://openalex.org/W3046569229","https://openalex.org/W2004652094"],"abstract_inverted_index":{"The":[0,101],"process":[1],"of":[2,33,49,97,104],"HIV-1":[3,65,98],"assembly":[4,51],"and":[5,52,94,156],"release,":[6],"which":[7,43],"occurs":[8],"largely":[9],"at":[10],"the":[11,17,30,34,39,47,54,92,114,142],"plasma":[12,115],"membrane,":[13,116],"is":[14],"driven":[15],"by":[16,42,119],"Gag":[18,23,44,59,99,105,112,136,154],"precursor":[19],"protein,":[20],"Pr55Gag.":[21],"Because":[22],"plays":[24,106],"a":[25,123],"central":[26],"role":[27,109],"in":[28,83,110,117,135,141,152],"orchestrating":[29],"late":[31],"stages":[32],"virus":[35,50,157],"replication":[36],"cycle,":[37],"elucidating":[38],"molecular":[40],"mechanism":[41],"traffics":[45],"to":[46,63,73,77,113,133],"site":[48],"defining":[53],"cellular":[55,95,127],"machinery":[56],"that":[57],"regulates":[58],"localization":[60],"are":[61,144],"crucial":[62],"understanding":[64,147],"replication.":[66],"Ultimately,":[67],"this":[68,79],"information":[69],"will":[70],"be":[71],"vital":[72],"devising":[74],"effective":[75],"approaches":[76],"controlling":[78],"pathogen.":[80],"Numerous":[81],"studies":[82],"recent":[84],"years":[85],"have":[86,129],"provided":[87],"new":[88],"insights":[89],"into":[90],"both":[91],"viral":[93],"determinants":[96],"trafficking.":[100],"matrix":[102],"domain":[103],"an":[107],"important":[108],"directing":[111],"part":[118],"directly":[120],"interacting":[121],"with":[122],"specific":[124],"phosphoinositide.":[125],"Several":[126],"proteins":[128],"also":[130],"been":[131],"reported":[132],"function":[134,151],"trafficking":[137],"pathways.":[138],"Current":[139],"efforts":[140],"field":[143],"directed":[145],"toward":[146],"how":[148],"these":[149],"factors":[150],"promoting":[153],"transport":[155],"assembly.":[158]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
