{"id":"https://openalex.org/W1967058825","doi":"https://doi.org/10.1097/00005344-199702000-00011","title":"Inflammatory Cytokines Cause Coronary Arteriosclerosis-Like Changes and Alterations in the Smooth-Muscle Phenotypes in Pigs","display_name":"Inflammatory Cytokines Cause Coronary Arteriosclerosis-Like Changes and Alterations in the Smooth-Muscle Phenotypes in Pigs","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W1967058825","doi":"https://doi.org/10.1097/00005344-199702000-00011","mag":"1967058825","pmid":"https://pubmed.ncbi.nlm.nih.gov/9057072"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199702000-00011","doi":"https://doi.org/10.1097/00005344-199702000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199702000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037302816","display_name":"Yoshihiro Fukumoto","orcid":"https://orcid.org/0000-0002-8947-109X","observed_orcids":["https://orcid.org/0000-0002-8947-109X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihiro Fukumoto","raw_affiliation_strings":["Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012657143","display_name":"Hiroaki Shimokawa","orcid":"https://orcid.org/0000-0001-7534-4826","observed_orcids":["https://orcid.org/0000-0001-7534-4826"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroaki Shimokawa","raw_affiliation_strings":["Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","Res. Institute of Angiocardiology, Cardiovascular Clinic, Kyushu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Res. Institute of Angiocardiology, Cardiovascular Clinic, Kyushu University School of Medicine","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006113054","display_name":"Akira It\u00f4","orcid":"https://orcid.org/0000-0001-8393-0518","observed_orcids":["https://orcid.org/0000-0001-8393-0518"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Ito","raw_affiliation_strings":["Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043550992","display_name":"Toshiaki Kadokami","orcid":"https://orcid.org/0000-0001-9017-700X","observed_orcids":["https://orcid.org/0000-0001-9017-700X"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiaki Kadokami","raw_affiliation_strings":["Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052888381","display_name":"Yoshikazu Yonemitsu","orcid":"https://orcid.org/0000-0002-1343-3927","observed_orcids":["https://orcid.org/0000-0002-1343-3927"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Yonemitsu","raw_affiliation_strings":["First Department of Pathology, Kyushu University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Kyushu University, School of Medicine","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064861833","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Third Department of Internal Medicine, Tokyo University School of Medicine, Tokyo","The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Tokyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113068955","display_name":"M. Koji Owada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Koji Owada","raw_affiliation_strings":["Kyoto Pharmaceutical University, Kyoto, Japan","Kyoto Pharmaceutical University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto Pharmaceutical University, Kyoto, Japan","institution_ids":["https://openalex.org/I25998863"]},{"raw_affiliation_string":"Kyoto Pharmaceutical University;","institution_ids":["https://openalex.org/I25998863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113957223","display_name":"Kensuke Egashira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kensuke Egashira","raw_affiliation_strings":["Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","Res. Institute of Angiocardiology, Cardiovascular Clinic, Kyushu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Res. Institute of Angiocardiology, Cardiovascular Clinic, Kyushu University School of Medicine","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110036983","display_name":"Katsuo Sueishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuo Sueishi","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111822040","display_name":"Ryozo Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryozo Nagai","raw_affiliation_strings":["Third Department of Internal Medicine, Tokyo University School of Medicine, Tokyo","The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Tokyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111524529","display_name":"Yoshio Yazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Yazaki","raw_affiliation_strings":["Third Department of Internal Medicine, Tokyo University School of Medicine, Tokyo","The University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Tokyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"The University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065901351","display_name":"Akira Takeshita","orcid":"https://orcid.org/0000-0003-3685-9055","observed_orcids":["https://orcid.org/0000-0003-3685-9055"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Takeshita","raw_affiliation_strings":["Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Angiocardiology and Cardiovascular Clinic and the \u2020First Department of Pathology, Kyushu University School of Medicine, Fukuoka","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006113054","https://openalex.org/A5012657143","https://openalex.org/A5037302816","https://openalex.org/A5043550992","https://openalex.org/A5065901351","https://openalex.org/A5113957223"],"corresponding_institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4210097767"],"apc_list":null,"apc_paid":null,"fwci":2.4905,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.88924011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"2","first_page":"222","last_page":"231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8220000267028809},{"id":"https://openalex.org/keywords/coronary-arteriosclerosis","display_name":"coronary arteriosclerosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":1.0},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.9380000233650208},{"id":"https://openalex.org/keywords/smooth-muscle-dedifferentiation","display_name":"smooth muscle dedifferentiation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/intimal-thickening","display_name":"intimal thickening","score":0.796999990940094},{"id":"https://openalex.org/keywords/serotonin-induced-vasoconstriction","display_name":"serotonin-induced vasoconstriction","score":0.7789999842643738},{"id":"https://openalex.org/keywords/porcine-coronary-artery-model","display_name":"porcine coronary artery model","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6473507285118103},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5892776250839233},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5758172273635864},{"id":"https://openalex.org/C2776393769","wikidata":"https://www.wikidata.org/wiki/Q184559","display_name":"Arteriosclerosis","level":2,"score":0.553355872631073},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5142499804496765},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.508363664150238},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5062590837478638},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.49665647745132446},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.4849703311920166},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.46315163373947144},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4545736014842987},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4413226246833801},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4381019175052643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42521148920059204},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40142977237701416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2190721035003662},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.19333767890930176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199702000-00011","doi":"https://doi.org/10.1097/00005344-199702000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199702000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:9057072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9057072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W260637170","https://openalex.org/W1566351800","https://openalex.org/W1603224226","https://openalex.org/W1967578418","https://openalex.org/W1969863130","https://openalex.org/W1981429363","https://openalex.org/W1982457725","https://openalex.org/W1996200557","https://openalex.org/W2007210699","https://openalex.org/W2013545198","https://openalex.org/W2026248402","https://openalex.org/W2028329330","https://openalex.org/W2038300967","https://openalex.org/W2041741856","https://openalex.org/W2048325240","https://openalex.org/W2056225363","https://openalex.org/W2084378947","https://openalex.org/W2095085620","https://openalex.org/W2096428903","https://openalex.org/W2104019390","https://openalex.org/W2109913253","https://openalex.org/W2114278094","https://openalex.org/W2122462682","https://openalex.org/W2125751345","https://openalex.org/W2126590643","https://openalex.org/W2137570167","https://openalex.org/W2155291282","https://openalex.org/W2156733798","https://openalex.org/W2164784231","https://openalex.org/W2172413152","https://openalex.org/W2265277925","https://openalex.org/W2398629262","https://openalex.org/W2409287186","https://openalex.org/W3196550503"],"related_works":["https://openalex.org/W2114278094","https://openalex.org/W4205546246","https://openalex.org/W2350615304","https://openalex.org/W2160065782","https://openalex.org/W2389770110","https://openalex.org/W4247304343","https://openalex.org/W1421685253","https://openalex.org/W2044945421","https://openalex.org/W4318173906","https://openalex.org/W2047972161"],"abstract_inverted_index":{"We":[0],"recently":[1],"developed":[2],"a":[3,175],"porcine":[4,67],"model":[5],"in":[6,59,143,149,191],"which":[7,186],"chronic,":[8],"local":[9],"treatment":[10],"with":[11,57,73,153,189],"interleukin-1":[12,41],"beta":[13],"(IL-1":[14,43],"beta)":[15],"causes":[16],"coronary":[17,49,68,88,146,180],"arteriosclerosis-like":[18,181],"changes":[19,182],"and":[20,40,51,80,123,137,157,162,183],"hyperconstrictive":[21,102,184],"responses.":[22],"This":[23],"study":[24],"was":[25,70,116,165],"designed":[26],"to":[27,178],"examine":[28],"whether":[29,52],"or":[30,110],"not":[31],"other":[32],"major":[33],"inflammatory":[34,154,171],"cytokines":[35,172],"[tumor":[36],"necrosis":[37],"factor-alpha":[38],"(TNF-alpha)":[39],"alpha":[42],"alpha)":[44],"might":[45],"also":[46],"cause":[47],"similar":[48,176],"responses":[50,54,103],"those":[53,119],"are":[55,187],"associated":[56,188],"alterations":[58,190],"the":[60,66,86,91,98,144,150],"smooth-muscle":[61,192],"phenotypes.":[62],"A":[63],"segment":[64],"of":[65,93],"artery":[69],"aseptically":[71],"wrapped":[72],"cotton":[74],"mesh,":[75],"absorbing":[76],"IL-1":[77,81],"beta,":[78],"TNF-alpha,":[79],"alpha.":[82],"Two":[83],"weeks":[84],"after":[85],"operation,":[87],"arteriography":[89],"showed":[90],"development":[92],"mild":[94,113],"stenotic":[95],"lesions":[96],"at":[97,118],"cytokine-treated":[99,120],"sites,":[100],"where":[101],"were":[104,141,159],"repeatedly":[105],"induced":[106],"by":[107],"intracoronary":[108],"serotonin":[109],"histamine.":[111],"Histologically":[112],"intimal":[114],"thickening":[115],"noted":[117,142],"sites.":[121],"Immunostaining":[122],"immunoblotting":[124],"demonstrated":[125],"that":[126,170],"all":[127,173],"three":[128],"myosin":[129],"heavy":[130],"chain":[131],"isoforms,":[132],"SM1,":[133],"SM2":[134,158],"(smooth-muscle":[135],"type),":[136,140],"SMemb":[138,164],"(nonmuscle":[139],"normal":[145],"segments,":[147],"whereas":[148],"segments":[151],"treated":[152],"cytokines,":[155],"SM1":[156],"markedly":[160],"reduced,":[161],"only":[163],"noted.":[166],"These":[167],"results":[168],"indicate":[169],"have":[174],"ability":[177],"induce":[179],"responses,":[185],"phenotypes":[193],"toward":[194],"dedifferentiation.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
